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Closing gaps in the human genome using sequencing by synthesis.
|Publication Type||Journal Article|
|Authors||Garber, M., Zody MC, Arachchi HM, Berlin A., Gnerre S., Green LM, Lennon N., and Nusbaum C.|
|Abstract||The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15.|
|Year of Publication||2009|
|Date Published (YYYY/MM/DD)||2009/01/01|