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Closing gaps in the human genome using sequencing by synthesis.
| Publication Type | Journal Article |
| Authors | Garber, M., Zody MC, Arachchi HM, Berlin A., Gnerre S., Green LM, Lennon N., and Nusbaum C. |
| Abstract | The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15. |
| Year of Publication | 2009 |
| Journal | Genome biology |
| Volume | 10 |
| Issue | 6 |
| Pages | R60 |
| Date Published (YYYY/MM/DD) | 2009/01/01 |
| ISSN Number | 1465-6906 |
| DOI | 10.1186/gb-2009-10-6-r60 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/19490611?dopt=Abstract |
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