Scientific Publications

Assisted assembly: how to improve a de novo genome assembly by using related species.

Publication TypeJournal Article
AuthorsGnerre, S., Lander E. S., Lindblad-Toh K., and Jaffe DB
AbstractWe describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.
Year of Publication2012
JournalGenome biology
Volume10
Issue8
PagesR88
Date Published (YYYY/MM/DD)2012/01/09
ISSN Number1465-6906
DOI10.1186/gb-2009-10-8-r88
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19712469?dopt=Abstract