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Assisted assembly: how to improve a de novo genome assembly by using related species.
| Publication Type | Journal Article |
| Authors | Gnerre, S., Lander E. S., Lindblad-Toh K., and Jaffe DB |
| Abstract | We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly. |
| Year of Publication | 2012 |
| Journal | Genome biology |
| Volume | 10 |
| Issue | 8 |
| Pages | R88 |
| Date Published (YYYY/MM/DD) | 2012/01/09 |
| ISSN Number | 1465-6906 |
| DOI | 10.1186/gb-2009-10-8-r88 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/19712469?dopt=Abstract |
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