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Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells.
| Publication Type | Journal Article |
| Authors | Pizzirani, D., Roberti M., Grimaudo S., Di Cristina A., Pipitone RM, Tolomeo M., and Recanatini M. |
| Abstract | With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells. |
| Year of Publication | 2009 |
| Journal | Journal of medicinal chemistry |
| Volume | 52 |
| Issue | 21 |
| Pages | 6936-40 |
| Date Published (YYYY/MM/DD) | 2009/11/12 |
| ISSN Number | 0022-2623 |
| DOI | 10.1021/jm900907s |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/19764793?dopt=Abstract |
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