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Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells.
|Publication Type||Journal Article|
|Authors||Pizzirani, D., Roberti M., Grimaudo S., Di Cristina A., Pipitone RM, Tolomeo M., and Recanatini M.|
|Abstract||With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.|
|Year of Publication||2009|
|Journal||Journal of medicinal chemistry|
|Date Published (YYYY/MM/DD)||2009/11/12|