Scientific Publications

Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells.

Publication TypeJournal Article
AuthorsPizzirani, D., Roberti M., Grimaudo S., Di Cristina A., Pipitone RM, Tolomeo M., and Recanatini M.
AbstractWith the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.
Year of Publication2009
JournalJournal of medicinal chemistry
Volume52
Issue21
Pages6936-40
Date Published (YYYY/MM/DD)2009/11/12
ISSN Number0022-2623
DOI10.1021/jm900907s
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19764793?dopt=Abstract