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Copper-mediated amidation of heterocyclic and aromatic C-H bonds.
|Publication Type||Journal Article|
|Authors||Wang, Q., and Schreiber SL|
|Abstract||A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.|
|Year of Publication||2009|
|Date Published (YYYY/MM/DD)||2009/11/19|