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| Publication Type | Journal Article |
| Authors | Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. |
| Abstract | The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived as nonselective. The synthesis and study of a focused library of cinnamic hydroxamates allowed the identification of, to our knowledge, the first nonselective HDAC inhibitor. These data will guide a more informed use of HDAC inhibitors as chemical probes and therapeutic agents. |
| Year of Publication | 2010 |
| Journal | Nature chemical biology |
| Volume | 6 |
| Issue | 3 |
| Pages | 238-243 |
| Date Published (YYYY/MM/DD) | 2010/03/01 |
| ISSN Number | 1552-4450 |
| DOI | 10.1038/nchembio.313 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/20139990?dopt=Abstract |
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