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Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.
| Publication Type | Journal Article |
| Authors | Stanley, SA, and Hung DT |
| Abstract | Loss-of-function genetic screens have facilitated great strides in our understanding of the biology of model organisms but have not been possible in diploid human cells. A recent report by Brummelkamp's group in Science describes the use of insertional mutagenesis to generate loss-of-function alleles in a largely haploid human cell line and demonstrates the versatility of this method in screens designed to investigate the host/pathogen interaction. This approach has strengths that are complementary to existing strategies and will facilitate progress toward a systems-level understanding of infectious disease and ultimately the development of new therapeutics. |
| Year of Publication | 2009 |
| Journal | Science translational medicine |
| Volume | 1 |
| Issue | 11 |
| Pages | 11ps13 |
| Date Published (YYYY/MM/DD) | 2009/12/16 |
| ISSN Number | 1946-6234 |
| DOI | 10.1126/scitranslmed.3000550 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/20371455?dopt=Abstract |
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