Scientific Publications

Candidate gene association resource (CARe): design, methods, and proof of concept.

Publication TypeJournal Article
AuthorsMusunuru, K., Lettre G., Young T., Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q., Chen MH, Lapchyk N., Crenshaw A., Ziaugra L., Rachupka A., Benjamin EJ, Cupples LA, Fornage M., Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C., Nizzari MM, Paltoo DN, Papanicolaou GJ, Patel SR, Psaty BM, Rader DJ, Redline S., Rich SS, Rotter JI, Taylor HA Jr, Tracy RP, Vasan RS, Wilson JG, Kathiresan S., Fabsitz RR, Boerwinkle E., Gabriel SB, and NHLBI Candidate Gene Association Resource
AbstractThe National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe), a planned cross-cohort analysis of genetic variation in cardiovascular, pulmonary, hematologic, and sleep-related traits, comprises >40,000 participants representing 4 ethnic groups in 9 community-based cohorts. The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans.
Year of Publication2010
JournalCirculation. Cardiovascular genetics
Volume3
Issue3
Pages267-75
Date Published (YYYY/MM/DD)2010/06/01
ISSN Number1942-325X
DOI10.1161/CIRCGENETICS.109.882696
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20400780?dopt=Abstract