Scientific Publications

SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.

Publication TypeJournal Article
AuthorsNeafsey, DE, Lawniczak MK, Park DJ, Redmond SN, Coulibaly MB, Traoré SF, Sagnon N., Costantini C., Johnson C., Wiegand RC, Collins FH, Lander E. S., Wirth DF, Kafatos FC, Besansky NJ, Christophides GK, and Muskavitch MA
AbstractMosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.
Year of Publication2010
JournalScience (New York, N.Y.)
Volume330
Issue6003
Pages514-7
Date Published (YYYY/MM/DD)2010/10/22
ISSN Number0036-8075
DOI10.1126/science.1193036
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20966254?dopt=Abstract