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mRNA expression signature of Gleason grade predicts lethal prostate cancer.
| Publication Type | Journal Article |
| Authors | Penney, KL, Sinnott JA, Fall K., Pawitan Y., Hoshida Y., Kraft P., Stark JR, Fiorentino M., Perner S., Finn S., Calza S., Flavin R., Freedman ML, Setlur S., Sesso HD, Andersson SO, Martin N., Kantoff PW, Johansson JE, Adami HO, Rubin MA, Loda M., Golub T. R., Andrén O., Stampfer MJ, and Mucci LA |
| Abstract | Prostate-specific antigen screening has led to enormous overtreatment of prostate cancer because of the inability to distinguish potentially lethal disease at diagnosis. We reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors, the most common grade, and the most indeterminate in terms of prognosis. |
| Year of Publication | 2011 |
| Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology |
| Volume | 29 |
| Issue | 17 |
| Pages | 2391-6 |
| Date Published (YYYY/MM/DD) | 2011/06/10 |
| ISSN Number | 0732-183X |
| DOI | 10.1200/JCO.2010.32.6421 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/21537050?dopt=Abstract |
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