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Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.
| Publication Type | Journal Article |
| Authors | Wang, Y., Jimenez M., Hansen AS, Raiber EA, Schreiber SL, and Young DW |
| Abstract | Introducing a silyl group at one of the internal olefin positions in diolefinic substrates results in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this method to a range of macrocyclic (E)-alkenylsiloxanes is described. Protodesilylation of alkenylsiloxane products yields novel Z-configured macrocycles. |
| Year of Publication | 2011 |
| Journal | Journal of the American Chemical Society |
| Volume | 133 |
| Issue | 24 |
| Pages | 9196-9 |
| Date Published (YYYY/MM/DD) | 2011/06/22 |
| ISSN Number | 0002-7863 |
| DOI | 10.1021/ja202012s |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/21557625?dopt=Abstract |
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