Scientific Publications

Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.

Publication TypeJournal Article
AuthorsWang, Y., Jimenez M., Hansen AS, Raiber EA, Schreiber SL, and Young DW
AbstractIntroducing a silyl group at one of the internal olefin positions in diolefinic substrates results in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this method to a range of macrocyclic (E)-alkenylsiloxanes is described. Protodesilylation of alkenylsiloxane products yields novel Z-configured macrocycles.
Year of Publication2011
JournalJournal of the American Chemical Society
Volume133
Issue24
Pages9196-9
Date Published (YYYY/MM/DD)2011/06/22
ISSN Number0002-7863
DOI10.1021/ja202012s
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21557625?dopt=Abstract