Scientific Publications

Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

Publication TypeJournal Article
AuthorsPeng, LF, Schaefer EA, Maloof N., Skaff A., Berical A., Belon CA, Heck JA, Lin W., Frick DN, Allen TM, Miziorko HM, Schreiber SL, and Chung RT
AbstractHepatitis C virus (HCV) chronically infects >170 million persons worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. The identification of more effective and better-tolerated agents for treating HCV is a high priority. We have reported elsewhere the discovery of the anti-HCV compound ceestatin using a high-throughput screen of a small molecule library.
Year of Publication2011
JournalThe Journal of infectious diseases
Volume204
Issue4
Pages609-16
Date Published (YYYY/MM/DD)2011/08/15
ISSN Number0022-1899
DOI10.1093/infdis/jir303
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21791663?dopt=Abstract