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Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
| Publication Type | Journal Article |
| Authors | Peng, LF, Schaefer EA, Maloof N., Skaff A., Berical A., Belon CA, Heck JA, Lin W., Frick DN, Allen TM, Miziorko HM, Schreiber SL, and Chung RT |
| Abstract | Hepatitis C virus (HCV) chronically infects >170 million persons worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. The identification of more effective and better-tolerated agents for treating HCV is a high priority. We have reported elsewhere the discovery of the anti-HCV compound ceestatin using a high-throughput screen of a small molecule library. |
| Year of Publication | 2011 |
| Journal | The Journal of infectious diseases |
| Volume | 204 |
| Issue | 4 |
| Pages | 609-16 |
| Date Published (YYYY/MM/DD) | 2011/08/15 |
| ISSN Number | 0022-1899 |
| DOI | 10.1093/infdis/jir303 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/21791663?dopt=Abstract |
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