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Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.
| Publication Type | Journal Article |
| Authors | Dandapani, S., Lowe JT, Comer E., and Marcaurelle LA |
| Abstract | An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained. |
| Year of Publication | 2011 |
| Journal | The Journal of organic chemistry |
| Volume | 76 |
| Issue | 19 |
| Pages | 8042-8 |
| Date Published (YYYY/MM/DD) | 2011/10/07 |
| ISSN Number | 0022-3263 |
| DOI | 10.1021/jo2011957 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/21875084?dopt=Abstract |
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