Scientific Publications

Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

Publication TypeJournal Article
AuthorsDandapani, S., Lowe JT, Comer E., and Marcaurelle LA
AbstractAn efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.
Year of Publication2011
JournalThe Journal of organic chemistry
Volume76
Issue19
Pages8042-8
Date Published (YYYY/MM/DD)2011/10/07
ISSN Number0022-3263
DOI10.1021/jo2011957
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21875084?dopt=Abstract