Scientific Publications

The genome of the green anole lizard and a comparative analysis with birds and mammals.

Publication TypeJournal Article
AuthorsAlföldi, J., Di Palma F., Grabherr M., Williams C., Kong L., Mauceli E., Russell P., Lowe CB, Glor RE, Jaffe JD, Ray DA, Boissinot S., Shedlock AM, Botka C., Castoe TA, Colbourne JK, Fujita MK, Moreno RG, ten Hallers BF, Haussler D., Heger A., Heiman D., Janes DE, Johnson J., de Jong PJ, Koriabine MY, Lara M., Novick PA, Organ CL, Peach SE, Poe S., Pollock DD, de Queiroz K., Sanger T., Searle S., Smith JD, Smith Z., Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., Edwards SV, Glenn TC, Schneider CJ, Losos JB, Lander E. S., Breen M., Ponting CP, and Lindblad-Toh K.
AbstractThe evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments. Among amniotes, genome sequences are available for mammals and birds, but not for non-avian reptiles. Here we report the genome sequence of the North American green anole lizard, Anolis carolinensis. We find that A. carolinensis microchromosomes are highly syntenic with chicken microchromosomes, yet do not exhibit the high GC and low repeat content that are characteristic of avian microchromosomes. Also, A. carolinensis mobile elements are very young and diverse-more so than in any other sequenced amniote genome. The GC content of this lizard genome is also unusual in its homogeneity, unlike the regionally variable GC content found in mammals and birds. We describe and assign sequence to the previously unknown A. carolinensis X chromosome. Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins. An anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations.
Year of Publication2011
JournalNature
Volume477
Issue7366
Pages587-91
Date Published (YYYY/MM/DD)2011/08/31
ISSN Number0028-0836
DOI10.1038/nature10390
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21881562?dopt=Abstract