Scientific Publications

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.

Publication TypeJournal Article
AuthorsLi, H.
AbstractMost existing methods for DNA sequence analysis rely on accurate sequences or genotypes. However, in applications of the next-generation sequencing (NGS), accurate genotypes may not be easily obtained (e.g. multi-sample low-coverage sequencing or somatic mutation discovery). These applications press for the development of new methods for analyzing sequence data with uncertainty.
Year of Publication2011
JournalBioinformatics (Oxford, England)
Volume27
Issue21
Pages2987-93
Date Published (YYYY/MM/DD)2011/11/01
ISSN Number1367-4803
DOI10.1093/bioinformatics/btr509
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21903627?dopt=Abstract