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Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.
| Publication Type | Journal Article |
| Authors | Zhong, C., Wang Y., Hung AW, Schreiber SL, and Young DW |
| Abstract | An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to result in 3,5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were obtained selectively using chiral substrates and an achiral Pd(II) complex or strong Brønsted acid catalysis. A range of substrates undergoes these selective transformations. Functionalization of the resulting products yielding bicyclic heterocycles is also demonstrated. |
| Year of Publication | 2011 |
| Journal | Organic letters |
| Volume | 13 |
| Issue | 20 |
| Pages | 5556-9 |
| Date Published (YYYY/MM/DD) | 2011/10/21 |
| ISSN Number | 1523-7060 |
| DOI | 10.1021/ol202276h |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/21916463?dopt=Abstract |
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