Scientific Publications

Distribution Pattern of Plasmodium falciparum Chloroquine Transporter (pfcrt) Gene Haplotypes in Sri Lanka 1996-2006.

Publication TypeJournal Article
AuthorsZhang, JJ, Senaratne TN, Daniels R., Valim C., Alifrangis M., Amerasinghe P., Konradsen F., Rajakaruna R., Wirth DF, and Karunaweera ND
AbstractAbstract. Widespread antimalarial resistance has been a barrier to malaria elimination efforts in Sri Lanka. Analysis of genetic markers in historic parasites may uncover trends in the spread of resistance. We examined the frequency of Plasmodium falciparum chloroquine transporter (pfcrt; codons 72-76) haplotypes in Sri Lanka in 1996-1998 and 2004-2006 using a high-resolution melting assay. Among 59 samples from 1996 to 1998, we detected the SVMNT (86%), CVMNK (10%), and CVIET (2%) haplotypes, with a positive trend in SVMNT and a negative trend in CVMNK frequency (P = 0.004) over time. Among 24 samples from 2004 to 2006, we observed only the SVMNT haplotype. This finding indicates selection for the SVMNT haplotype over time and its possible fixation in the population.
Year of Publication2011
JournalThe American journal of tropical medicine and hygiene
Volume85
Issue5
Pages811-4
Date Published (YYYY/MM/DD)2011/11/01
ISSN Number0002-9637
DOI10.4269/ajtmh.2011.11-0167
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22049031?dopt=Abstract