New Publications

Development of small-molecule probes that selectively kill cells induced to express mutant RAS.
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Resource partitioning and sympatric differentiation among closely related bacterioplankton.
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High-quality draft genome sequences of 28 Enterococcus sp. isolates.
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Vibrio chromosomes share common history.
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A catalog of reference genomes from the human microbiome.
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Scientific Publications

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2012

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity.Shaham, O., Wei R., Wang TJ, Ricciardi C., Lewis GD, Vasan RS, Carr SA, Thadhani R., Gerszten RE, and Mootha VK Molecular systems biology, 2012/01/09, Volume 4, p.214, (2012) Read More / View Supplemental Materials

2011

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.Wang, L., Lawrence MS, Wan Y., Stojanov P., Sougnez C., Stevenson K., Werner L., Sivachenko A., Deluca DS, Zhang L., Zhang W., Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, Cibulskis K., Tesar B., Sievers QL, Shefler E., Gabriel S., et al. The New England journal of medicine, 2011/12/29, Volume 365, Issue 26, p.2497-506, (2011) Read More / View Supplemental Materials

Low Plasma Level of Atrial Natriuretic Peptide Predicts Development of Diabetes: The Prospective Malmo Diet and Cancer Study.Magnusson, M., Jujic A., Hedblad B., Engström G., Persson M., Struck J., Morgenthaler NG, Nilsson P., Newton-Cheh C., Wang TJ, and Melander O. The Journal of clinical endocrinology and metabolism, 2011/11/23, (2011) Read More / View Supplemental Materials

Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.Zhong, C., Wang Y., Hung AW, Schreiber SL, and Young DW Organic letters, 2011/10/21, Volume 13, Issue 20, p.5556-9, (2011) Read More / View Supplemental Materials

The mutational landscape of head and neck squamous cell carcinoma.Stransky, N., Egloff AM, Tward AD, Kostic AD, Cibulskis K., Sivachenko A., Kryukov GV, Lawrence MS, Sougnez C., McKenna A., Shefler E., Ramos AH, Stojanov P., Carter SL, Voet D., Cortés ML, Auclair D., Berger MF, Saksena G., Guiducci C., et al. Science (New York, N.Y.), 2011/08/26, Volume 333, Issue 6046, p.1157-60, (2011) Read More / View Supplemental Materials

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Kuai, L., Ong SE, Madison JM, Wang X., Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, and Haggarty SJ Chemistry & biology, 2011/07/29, Volume 18, Issue 7, p.891-906, (2011) Read More / View Supplemental Materials

A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials

Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Wang, Y., Jimenez M., Hansen AS, Raiber EA, Schreiber SL, and Young DW Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9196-9, (2011) Read More / View Supplemental Materials

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X., Liu Y., Kubicek S., Myllyharju J., Tumber A., Ng S., Che KH, Podoll J., Heightman TD, Oppermann U., Schreiber SL, and Wang X. Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9451-6, (2011) Read More / View Supplemental Materials

Mapping and analysis of chromatin state dynamics in nine human cell types.Ernst, J., Kheradpour P., Mikkelsen TS, Shoresh N., Ward LD, Epstein CB, Zhang X., Wang L., Issner R., Coyne M., Ku M., Durham T., Kellis M., and Bernstein BE Nature, 2011/05/05, Volume 473, Issue 7345, p.43-9, (2011) Read More / View Supplemental Materials

Route to three-dimensional fragments using diversity-oriented synthesis.Hung, AW, Ramek A., Wang Y., Kaya T., Wilson JA, Clemons PA, and Young DW Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6799-804, (2011) Read More / View Supplemental Materials

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.Rhee, EP, Cheng S., Larson MG, Walford GA, Lewis GD, McCabe E., Yang E., Farrell L., Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, and Gerszten RE The Journal of clinical investigation, 2011/04/01, Volume 121, Issue 4, p.1402-11, (2011) Read More / View Supplemental Materials

Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.Ding, Z., Wu CJ, Chu GC, Xiao Y., Ho D., Zhang J., Perry SR, Labrot ES, Wu X., Lis R., Hoshida Y., Hiller D., Hu B., Jiang S., Zheng H., Stegh AH, Scott KL, Signoretti S., Bardeesy N., Wang YA, et al. Nature, 2011/02/10, Volume 470, Issue 7333, p.269-73, (2011) Read More / View Supplemental Materials

2010

Multivariate dependence and genetic networks inference.Margolin, AA, Wang K., Califano A., and Nemenman I. IET systems biology, 2010/11/01, Volume 4, Issue 6, p.428-40, (2010) Read More / View Supplemental Materials

Comparative epigenomic analysis of murine and human adipogenesis.Mikkelsen, TS, Xu Z., Zhang X., Wang L., Gimble JM, Lander E. S., and Rosen ED Cell, 2010/10/01, Volume 143, Issue 1, p.156-69, (2010) Read More / View Supplemental Materials

Integrating common and rare genetic variation in diverse human populations.International HapMap 3, Consortium, Altshuler DM, Gibbs RA, Peltonen L., Altshuler DM, Gibbs RA, Peltonen L., Dermitzakis E., Schaffner SF, Yu F., Peltonen L., Dermitzakis E., Bonnen PE, Altshuler DM, Gibbs RA, de Bakker PI, Deloukas P., Gabriel SB, Gwilliam R., Hunt S., et al. Nature, 2010/09/02, Volume 467, Issue 7311, p.52-8, (2010) Read More / View Supplemental Materials

MicroRNA miR-125a controls hematopoietic stem cell number.Guo, S., Lu J., Schlanger R., Zhang H., Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B., Merkenschlager M., Golub T. R., and Scadden DT Proceedings of the National Academy of Sciences of the United States of America, 2010/08/10, Volume 107, Issue 32, p.14229-34, (2010) Read More / View Supplemental Materials

Metabolic signatures of exercise in human plasma.Lewis, GD, Farrell L., Wood MJ, Martinovic M., Arany Z., Rowe GC, Souza A., Cheng S., McCabe EL, Yang E., Shi X., Deo R., Roth FP, Asnani A., Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, et al. Science translational medicine, 2010/05/26, Volume 2, Issue 33, p.33ra37, (2010) Read More / View Supplemental Materials

International network of cancer genome projects.International Cancer Genome, Consortium, Hudson T. J., Anderson W., Artez A., Barker AD, Bell C., Bernabé RR, Bhan MK, Calvo F., Eerola I., Gerhard DS, Guttmacher A., Guyer M., Hemsley FM, Jennings JL, Kerr D., Klatt P., Kolar P., Kusada J., Lane DP, et al. Nature, 2010/04/15, Volume 464, Issue 7291, p.993-8, (2010) Read More / View Supplemental Materials

Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.Tabb, DL, Vega-Montoto L., Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling B., Tegeler TJ, Wang M., Wang P., et al. Journal of proteome research, 2010/02/05, Volume 9, Issue 2, p.761-76, (2010) Read More / View Supplemental Materials

Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.Paulovich, AG, Billheimer D., Ham AJ, Vega-Montoto L., Rudnick PA, Tabb DL, Wang P., Blackman RK, Bunk DM, Cardasis HL, Clauser KR, Kinsinger CR, Schilling B., Tegeler TJ, Variyath AM, Wang M., Whiteaker JR, Zimmerman LJ, Fenyo D., Carr SA, et al. Molecular & cellular proteomics : MCP, 2010/02/01, Volume 9, Issue 2, p.242-54, (2010) Read More / View Supplemental Materials

Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.Rudnick, PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P., Blonder N., Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M., Neubert TA, Schilling B., Tabb DL, Tegeler TJ, Vega-Montoto L., Variyath AM, et al. Molecular & cellular proteomics : MCP, 2010/02/01, Volume 9, Issue 2, p.225-41, (2010) Read More / View Supplemental Materials

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.Kuai, L., Wang X., Madison JM, Schreiber SL, Scolnick EM, and Haggarty SJ ACS chemical neuroscience, 2010/01/28, Volume 1, Issue 4, p.325-342, (2010) Read More / View Supplemental Materials

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.Verhaak, RG, Hoadley KA, Purdom E., Wang V., Qi Y., Wilkerson MD, Miller CR, Ding L., Golub T., Mesirov J. P., Alexe G., Lawrence M., O'Kelly M., Tamayo P., Weir BA, Gabriel S., Winckler W., Gupta S., Jakkula L., Feiler HS, et al. Cancer cell, 2010/01/19, Volume 17, Issue 1, p.98-110, (2010) Read More / View Supplemental Materials

2009

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.Markljung, E., Jiang L., Jaffe JD, Mikkelsen TS, Wallerman O., Larhammar M., Zhang X., Wang L., Saenz-Vash V., Gnirke A., Lindroth AM, Barrés R., Yan J., Strömberg S., De S., Pontén F., Lander E. S., Carr SA, Zierath JR, Kullander K., et al. PLoS biology, 2009/12/01, Volume 7, Issue 12, p.e1000256, (2009) Read More / View Supplemental Materials

Copper-mediated amidation of heterocyclic and aromatic C-H bonds.Wang, Q., and Schreiber SL Organic letters, 2009/11/19, Volume 11, Issue 22, p.5178-80, (2009) Read More / View Supplemental Materials

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.Peng, LF, Stanton BZ, Maloof N., Wang X., and Schreiber SL Bioorganic & medicinal chemistry letters, 2009/11/15, Volume 19, Issue 22, p.6319-25, (2009) Read More / View Supplemental Materials

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.Olson, P., Lu J., Zhang H., Shai A., Chun MG, Wang Y., Libutti SK, Nakakura EK, Golub T. R., and Hanahan D. Genes & development, 2009/09/15, Volume 23, Issue 18, p.2152-65, (2009) Read More / View Supplemental Materials

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.Addona, TA, Abbatiello SE, Schilling B., Skates SJ, Mani D. R., Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H., Hall SC, Allen S., Blackman RK, Borchers CH, Buck C., Cardasis HL, Cusack MP, Dodder NG, Gibson BW, Held JM, et al. Nature biotechnology, 2009/07/01, Volume 27, Issue 7, p.633-41, (2009) Read More / View Supplemental Materials

Automated high-dimensional flow cytometric data analysis.Pyne, S., Hu X., Wang K., Rossin E., Lin TI, Maier LM, Baecher-Allan C., McLachlan GJ, Tamayo P., Hafler DA, De Jager PL, and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2009/05/26, Volume 106, Issue 21, p.8519-24, (2009) Read More / View Supplemental Materials

Identifying the proteins to which small-molecule probes and drugs bind in cells.Ong, SE, Schenone M., Margolin AA, Li X., Do K., Doud MK, Mani D. R., Kuai L., Wang X., Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub T. R., Gould RJ, Schreiber SL, and Carr SA Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4617-22, (2009) Read More / View Supplemental Materials

A small molecule that binds Hedgehog and blocks its signaling in human cells.Stanton, BZ, Peng LF, Maloof N., Nakai K., Wang X., Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A., and Schreiber SL Nature chemical biology, 2009/03/01, Volume 5, Issue 3, p.154-6, (2009) Read More / View Supplemental Materials

2008

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.Li, Z., Lu J., Sun M., Mi S., Zhang H., Luo RT, Chen P., Wang Y., Yan M., Qian Z., Neilly MB, Jin J., Zhang Y., Bohlander SK, Zhang DE, Larson RA, Le Beau MM, Thirman MJ, Golub T. R., Rowley JD, et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/10/07, Volume 105, Issue 40, p.15535-40, (2008) Read More / View Supplemental Materials

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.Tam, WF, Gu TL, Chen J., Lee BH, Bullinger L., Fröhling S., Wang A., Monti S., Golub T. R., and Gilliland DG Blood, 2008/09/01, Volume 112, Issue 5, p.1981-92, (2008) Read More / View Supplemental Materials

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway.Gray, BL, Wang X., Brown WC, Kuai L., and Schreiber SL Organic letters, 2008/07/03, Volume 10, Issue 13, p.2621-4, (2008) Read More / View Supplemental Materials

MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.Lu, J., Guo S., Ebert BL, Zhang H., Peng X., Bosco J., Pretz J., Schlanger R., Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, and Golub T. R. Developmental cell, 2008/06/01, Volume 14, Issue 6, p.843-53, (2008) Read More / View Supplemental Materials

MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitorsLu, Jun, Guo Shangqin, Ebert Benjamin L., Zhang Hao, Peng Xiao, Bosco Jocelyn, Pretz Jennifer, Schlanger Rita, Wang Judy Y., Mak Raymond H., Dombkowski David M., Preffer Frederic I., Scadden David T., and Golub Todd R. Developmental Cell, 2008/06//, Volume 14, Issue 6, p.843 - 53, (2008) Read More / View Supplemental Materials

Small-molecule reagents for cellular pull-down experiments.Wang, X., Imber BS, and Schreiber SL Bioconjugate chemistry, 2008/03/01, Volume 19, Issue 3, p.585-7, (2008) Read More / View Supplemental Materials

2007

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.Mi, S., Lu J., Sun M., Li Z., Zhang H., Neilly MB, Wang Y., Qian Z., Jin J., Zhang Y., Bohlander SK, Le Beau MM, Larson RA, Golub T. R., Rowley JD, and Chen J. Proceedings of the National Academy of Sciences of the United States of America, 2007/12/11, Volume 104, Issue 50, p.19971-6, (2007) Read More / View Supplemental Materials

Evolution of genes and genomes on the Drosophila phylogeny.Drosophila 12 Genomes, Consortium, Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B., Markow TA, Kaufman TC, Kellis M., Gelbart W., Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B., Aguade M., Akashi H., et al. Nature, 2007/11/08, Volume 450, Issue 7167, p.203-18, (2007) Read More / View Supplemental Materials

Genome-wide detection and characterization of positive selection in human populations.Sabeti, PC, Varilly P., Fry B., Lohmueller J., Hostetter E., Cotsapas C., Xie X., Byrne EH, McCarroll SA, Gaudet R., Schaffner SF, Lander E. S., International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, et al. Nature, 2007/10/18, Volume 449, Issue 7164, p.913-8, (2007) Read More / View Supplemental Materials

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.ENCODE Project, Consortium, Birney E., Stamatoyannopoulos JA, Dutta A., Guigó R., Gingeras TR, Margulies EH, Weng Z., Snyder M., Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S., Koch CM, Asthana S., Malhotra A., Adzhubei I., Greenbaum JA, Andrews RM, et al. Nature, 2007/06/14, Volume 447, Issue 7146, p.799-816, (2007) Read More / View Supplemental Materials

High-throughput oncogene mutation profiling in human cancer.Thomas, RK, Baker AC, Debiasi RM, Winckler W., LaFramboise T., Lin WM, Wang M., Feng W., Zander T., MacConaill L., Lee JC, Nicoletti R., Hatton C., Goyette M., Girard L., Majmudar K., Ziaugra L., Wong KK, Gabriel S., Beroukhim R., et al. Nature genetics, 2007/03/01, Volume 39, Issue 3, p.347-51, (2007) Read More / View Supplemental Materials

2006

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9Krivtsov, Andrei V., Twomey David, Feng Zhaohui, Stubbs Matthew C., Wang Yingzi, Faber Joerg, Levine Jason E., Wang Jing, Hahn William C., Gilliland Gary D., Golub Todd R., and Armstrong Scott A. Nature, 2006/08/17/, Volume 442, Issue 7104, p.818 - 22, (2006) Read More / View Supplemental Materials

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.Krivtsov, AV, Twomey D., Feng Z., Stubbs MC, Wang Y., Faber J., Levine JE, Wang J., Hahn WC, Gilliland DG, Golub T. R., and Armstrong SA Nature, 2006/08/17, Volume 442, Issue 7104, p.818-22, (2006) Read More / View Supplemental Materials

Analysis of the DNA sequence and duplication history of human chromosome 15.Zody, MC, Garber M., Sharpe T., Young SK, Rowen L., O'Neill K., Whittaker CA, Kamal M., Chang JL, Cuomo CA, Dewar K., FitzGerald MG, Kodira CD, Madan A., Qin S., Yang X., Abbasi N., Abouelleil A., Arachchi HM, Baradarani L., et al. Nature, 2006/03/30, Volume 440, Issue 7084, p.671-5, (2006) Read More / View Supplemental Materials

2005

Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformationIsakoff, Michael S., Sansam Courtney G., Tamayo Pablo, Subramanian Aravind, Evans Julia A., Fillmore Christine M., Wang Xi, Biegel Jaclyn A., Pomeroy Scott L., Mesirov Jill P., and Roberts Charles W. M. Proceedings of the National Academy of Sciences of the United States of America, 2005/12/06/, Volume 102, Issue 49, p.17745 - 50, (2005) Read More / View Supplemental Materials

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements.Ramanathan, A., Wang C., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2005/04/26, Volume 102, Issue 17, p.5992-7, (2005) Read More / View Supplemental Materials

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.Wang, J., Iwasaki H., Krivtsov A., Febbo PG, Thorner AR, Ernst P., Anastasiadou E., Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub T. R., Armstrong SA, Akashi K., and Korsmeyer SJ The EMBO journal, 2005/01/26, Volume 24, Issue 2, p.368-81, (2005) Read More / View Supplemental Materials

2004

Loss of heterozygosity and its correlation with expression profiles in subclasses of invasive breast cancersWang, Zhigang C., Lin Ming, Wei Lee-Jen, Li Cheng, Miron Alexander, Lodeiro Gabriella, Harris Lyndsay, Ramaswamy Sridhar, Tanenbaum David M., Meyerson Matthew, Iglehart James D., and Richardson Andrea Cancer Research, 2004/01/01/, Volume 64, Issue 1, p.64 - 71, (2004) Read More / View Supplemental Materials