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  • Showing 1-23 of 23 Results
2012
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity.Shaham, O., Wei R., Wang TJ, Ricciardi C., Lewis GD, Vasan RS, Carr SA, Thadhani R., Gerszten RE, and Mootha VK Molecular systems biology, 2012/01/09, Volume 4, p.214, (2012) Read More / View Supplemental Materials
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2011
Disease gene discovery through integrative genomics.Giallourakis, C., Henson C., Reich M., Xie X., and Mootha VK Annual review of genomics and human genetics, 2011/12/08, Volume 6, p.381-406, (2011) Read More / View Supplemental Materials
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Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.Tucker, EJ, Hershman SG, Köhrer C., Belcher-Timme CA, Patel J., Goldberger OA, Christodoulou J., Silberstein JM, McKenzie M., Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, and Mootha VK Cell metabolism, 2011/09/07, Volume 14, Issue 3, p.428-34, (2011) Read More / View Supplemental Materials
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Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials
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2010
The mitochondrial proteome and human disease.Calvo, SE, and Mootha VK Annual review of genomics and human genetics, 2010/09/22, Volume 11, p.25-44, (2010) Read More / View Supplemental Materials
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Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.Segrè, AV, DIAGRAM Consortium, investigators MAGIC, Groop L., Mootha VK, Daly M. J., and Altshuler D. PLoS genetics, 2010/08/12, Volume 6, Issue 8, (2010) Read More / View Supplemental Materials
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Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.Gohil, VM, Sheth SA, Nilsson R., Wojtovich AP, Lee JH, Perocchi F., Chen W., Clish CB, and Mootha VK Nature biotechnology, 2010/03/01, Volume 28, Issue 3, p.249-55, (2010) Read More / View Supplemental Materials
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A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells.Shaham, O., Xu Q., Ramanathan A., Souza AL, Clish CB, and Mootha VK Proceedings of the National Academy of Sciences of the United States of America, 2010/01/26, Volume 107, Issue 4, p.1571-5, (2010) Read More / View Supplemental Materials
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2009
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.Calvo, SE, Pagliarini DJ, and Mootha VK Proceedings of the National Academy of Sciences of the United States of America, 2009/05/05, Volume 106, Issue 18, p.7507-12, (2009) Read More / View Supplemental Materials
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2008
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury.Lewis, GD, Wei R., Liu E., Yang E., Shi X., Martinovic M., Farrell L., Asnani A., Cyrille M., Ramanathan A., Shaham O., Berriz G., Lowry PA, Palacios IF, Taşan M., Roth FP, Min J., Baumgartner C., Keshishian H., Addona T., et al. The Journal of clinical investigation, 2008/10/01, Volume 118, Issue 10, p.3503-12, (2008) Read More / View Supplemental Materials
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A mitochondrial protein compendium elucidates complex I disease biologyPagliarini, David J., Calvo Sarah E., Chang Betty, Sheth Sunil A., Vafai Scott B., Ong Shao-En, Walford Geoffrey A., Sugiana Canny, Boneh Avihu, Chen William K., Hill David E., Vidal Marc, Evans James G., Thorburn David R., Carr Steven A., and Mootha Vamsi K. Cell, 2008/07/11/, Volume 134, Issue 1, p.112 - 23, (2008) Read More / View Supplemental Materials
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A mitochondrial protein compendium elucidates complex I disease biology.Pagliarini, DJ, Calvo SE, Chang B., Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C., Boneh A., Chen WK, Hill DE, Vidal M., Evans JG, Thorburn DR, Carr SA, and Mootha VK Cell, 2008/07/11, Volume 134, Issue 1, p.112-23, (2008) Read More / View Supplemental Materials
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Large-scale chemical dissection of mitochondrial function.Wagner, BK, Kitami T., Gilbert TJ, Peck D., Ramanathan A., Schreiber SL, Golub T. R., and Mootha VK Nature biotechnology, 2008/03/01, Volume 26, Issue 3, p.343-51, (2008) Read More / View Supplemental Materials
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2006
Systematic identification of human mitochondrial disease genes through integrative genomics.Calvo, S., Jain M., Xie X., Sheth SA, Chang B., Goldberger OA, Spinazzola A., Zeviani M., Carr SA, and Mootha VK Nature genetics, 2006/05/01, Volume 38, Issue 5, p.576-82, (2006) Read More / View Supplemental Materials
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2005
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesSubramanian, Aravind, Tamayo Pablo, Mootha Vamsi K., Mukherjee Sayan, Ebert Benjamin L., Gillette Michael A., Paulovich Amanda, Pomeroy Scott L., Golub Todd R., Lander Eric S., and Mesirov Jill P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25/, Volume 102, Issue 43, p.15545 - 50, (2005) Read More / View Supplemental Materials
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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Subramanian, A., Tamayo P., Mootha VK, Mukherjee S., Ebert BL, Gillette MA, Paulovich A., Pomeroy SL, Golub T. R., Lander E. S., and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25, Volume 102, Issue 43, p.15545-50, (2005) Read More / View Supplemental Materials
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Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammalsXie, Xiaohui, Lu Jun, Kulbokas E. J., Golub Todd R., Mootha Vamsi, Lindblad-Toh Kerstin, Lander Eric S., and Kellis Manolis Nature, 2005/03/17/, Volume 434, Issue 7031, p.338 - 45, (2005) Read More / View Supplemental Materials
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Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.Xie, X., Lu J., Kulbokas E. J., Golub T. R., Mootha V., Lindblad-Toh K., Lander E. S., and Kellis M. Nature, 2005/03/17, Volume 434, Issue 7031, p.338-45, (2005) Read More / View Supplemental Materials
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2004
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscleMootha, Vamsi K., Handschin Christoph, Arlow Dan, Xie Xiaohui, St Pierre Julie, Sihag Smita, Yang Wenli, Altshuler David, Puigserver Pere, Patterson Nick, Willy Patricia J., Schulman Ira G., Heyman Richard A., Lander Eric S., and Spiegelman Bruce M. Proceedings of the National Academy of Sciences of the United States of America, 2004/04/27/, Volume 101, Issue 17, p.6570 - 5, (2004) Read More / View Supplemental Materials
Abstract
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.Mootha, VK, Handschin C., Arlow D., Xie X., St Pierre J., Sihag S., Yang W., Altshuler D., Puigserver P., Patterson N., Willy PJ, Schulman IG, Heyman RA, Lander E. S., and Spiegelman BM Proceedings of the National Academy of Sciences of the United States of America, 2004/04/27, Volume 101, Issue 17, p.6570-5, (2004) Read More / View Supplemental Materials
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2003
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondriaMootha, Vamsi K., Bunkenborg Jakob, Olsen Jesper V., Hjerrild Majbrit, Wisniewski Jacek R., Stahl Erich, Bolouri Marjan S., Ray Heta N., Sihag Smita, Kamal Michael, Patterson Nick, Lander Eric S., and Mann Matthias Cell, 2003/11/26/, Volume 115, Issue 5, p.629 - 40, (2003) Read More / View Supplemental Materials
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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesMootha, Vamsi K., Lindgren Cecilia M., Eriksson Karl-Fredrik, Subramanian Aravind, Sihag Smita, Lehar Joseph, Puigserver Pere, Carlsson Emma, and Ridderstr Nature Genetics, 2003/07//, Volume 34, Issue 3, p.267 - 73, (2003) Read More / View Supplemental Materials
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Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomicsMootha, Vamsi K., Lepage Pierre, Miller Kathleen, Bunkenborg Jakob, Reich Michael, Hjerrild Majbrit, Delmonte Terrye, Villeneuve Amelie, Sladek Robert, Xu Fenghao, Mitchell Grant A., Morin Charles, Mann Matthias, Hudson Thomas J., Robinson Brian, and Rioux John D. Proceedings of the National Academy of Sciences of the United States of America, 2003/01/21/, Volume 100, Issue 2, p.605 - 10, (2003) Read More / View Supplemental Materials
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  • Showing 1-23 of 23 Results