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2011
Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea.Amselem, J., Cuomo CA, van Kan JA, Viaud M., Benito EP, Couloux A., Coutinho PM, de Vries RP, Dyer PS, Fillinger S., Fournier E., Gout L., Hahn M., Wincker P., Anthouard V., Chen Z., Danchin EG, Dasilva C., Güldener U., Henrissat B., et al. PLoS genetics, 2011/08/01, Volume 7, Issue 8, p.e1002230, (2011) Read More / View Supplemental Materials
Abstract
Humanized mice with ectopic artificial liver tissues.Chen, AA, Thomas DK, Ong LL, Schwartz RE, Golub T. R., and Bhatia SN Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11842-7, (2011) Read More / View Supplemental Materials
Abstract
Comparative genomics yields insights into niche adaptation of plant vascular wilt pathogens.Klosterman, SJ, Subbarao KV, Kang S., Veronese P., Gold SE, Thomma BP, Chen Z., Henrissat B., Lee YH, Park J., Garcia-Pedrajas MD, Barbara DJ, Anchieta A., de Jonge R., Santhanam P., Maruthachalam K., Atallah Z., Amyotte SG, Paz Z., Inderbitzin P., et al. PLoS pathogens, 2011/07/01, Volume 7, Issue 7, p.e1002137, (2011) Read More / View Supplemental Materials
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Full-length transcriptome assembly from RNA-Seq data without a reference genome.Grabherr, MG, Haas BJ, Yassour M., Levin JZ, Thompson DA, Amit I., Adiconis X., Fan L., Raychowdhury R., Zeng Q., Chen Z., Mauceli E., Hacohen N., Gnirke A., Rhind N., Di Palma F., Birren BW, Nusbaum C., Lindblad-Toh K., Friedman N., et al. Nature biotechnology, 2011/05/15, Volume 29, Issue 7, p.644-52, (2011) Read More / View Supplemental Materials
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Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Novershtern, N., Subramanian A., Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N., Yosef N., Chang CY, Shay T., Frampton GM, Drake AC, Leskov I., Nilsson B., Preffer F., Dombkowski D., Evans JW, Liefeld T., Smutko JS, Chen J., et al. Cell, 2011/01/21, Volume 144, Issue 2, p.296-309, (2011) Read More / View Supplemental Materials
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2010
Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.Chen, J., Armstrong AH, Koehler AN, and Hecht MH Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.17015-22, (2010) Read More / View Supplemental Materials
Abstract
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Speliotes, EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G., Jackson AU, Allen HL, Lindgren CM, Luan J., Mägi R., Randall JC, Vedantam S., Winkler TW, Qi L., Workalemahu T., Heid IM, Steinthorsdottir V., Stringham HM, Weedon MN, Wheeler E., et al. Nature genetics, 2010/11/01, Volume 42, Issue 11, p.937-48, (2010) Read More / View Supplemental Materials
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Candidate gene association resource (CARe): design, methods, and proof of concept.Musunuru, K., Lettre G., Young T., Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q., Chen MH, Lapchyk N., Crenshaw A., Ziaugra L., Rachupka A., Benjamin EJ, Cupples LA, Fornage M., Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C., et al. Circulation. Cardiovascular genetics, 2010/06/01, Volume 3, Issue 3, p.267-75, (2010) Read More / View Supplemental Materials
Abstract
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.Boulbes, D., Chen CH, Shaikenov T., Agarwal NK, Peterson TR, Addona TA, Keshishian H., Carr SA, Magnuson MA, Sabatini DM, and Sarbassov dos D. Molecular cancer research : MCR, 2010/06/01, Volume 8, Issue 6, p.896-906, (2010) Read More / View Supplemental Materials
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A catalog of reference genomes from the human microbiome.Human Microbiome Jumpstart Reference Strains, Consortium, Nelson KE, Weinstock GM, Highlander SK, Worley KC, Creasy HH, Wortman JR, Rusch DB, Mitreva M., Sodergren E., Chinwalla AT, Feldgarden M., Gevers D., Haas BJ, Madupu R., Ward DV, Birren BW, Gibbs RA, Methe B., Petrosino JF, et al. Science (New York, N.Y.), 2010/05/21, Volume 328, Issue 5981, p.994-9, (2010) Read More / View Supplemental Materials
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International network of cancer genome projects.International Cancer Genome, Consortium, Hudson T. J., Anderson W., Artez A., Barker AD, Bell C., Bernabé RR, Bhan MK, Calvo F., Eerola I., Gerhard DS, Guttmacher A., Guyer M., Hemsley FM, Jennings JL, Kerr D., Klatt P., Kolar P., Kusada J., Lane DP, et al. Nature, 2010/04/15, Volume 464, Issue 7291, p.993-8, (2010) Read More / View Supplemental Materials
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Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.Gohil, VM, Sheth SA, Nilsson R., Wojtovich AP, Lee JH, Perocchi F., Chen W., Clish CB, and Mootha VK Nature biotechnology, 2010/03/01, Volume 28, Issue 3, p.249-55, (2010) Read More / View Supplemental Materials
Abstract
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Saxena, R., Hivert MF, Langenberg C., Tanaka T., Pankow JS, Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson AU, Kao WH, Li M., Glazer NL, Manning AK, Luan J., Stringham HM, Prokopenko I., Johnson T., Grarup N., Boesgaard TW, et al. Nature genetics, 2010/02/01, Volume 42, Issue 2, p.142-8, (2010) Read More / View Supplemental Materials
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2009
Dicer1 functions as a haploinsufficient tumor suppressor.Kumar, MS, Pester RE, Chen CY, Lane K., Chin C., Lu J., Kirsch DG, Golub T. R., and Jacks T. Genes & development, 2009/12/01, Volume 23, Issue 23, p.2700-4, (2009) Read More / View Supplemental Materials
Abstract
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.Borowiak, M., Maehr R., Chen S., Chen AE, Tang W., Fox JL, Schreiber SL, and Melton DA Cell stem cell, 2009/04/03, Volume 4, Issue 4, p.348-58, (2009) Read More / View Supplemental Materials
Abstract
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.Chen, S., Borowiak M., Fox JL, Maehr R., Osafune K., Davidow L., Lam K., Peng LF, Schreiber SL, Rubin LL, and Melton D. Nature chemical biology, 2009/04/01, Volume 5, Issue 4, p.258-65, (2009) Read More / View Supplemental Materials
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A small molecule that binds Hedgehog and blocks its signaling in human cells.Stanton, BZ, Peng LF, Maloof N., Nakai K., Wang X., Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A., and Schreiber SL Nature chemical biology, 2009/03/01, Volume 5, Issue 3, p.154-6, (2009) Read More / View Supplemental Materials
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2008
Somatic mutations affect key pathways in lung adenocarcinoma.Ding, L., Getz G., Wheeler DA, Mardis ER, McLellan MD, Cibulskis K., Sougnez C., Greulich H., Muzny DM, Morgan MB, Fulton L., Fulton RS, Zhang Q., Wendl MC, Lawrence MS, Larson DE, Chen K., Dooling DJ, Sabo A., Hawes AC, et al. Nature, 2008/10/23, Volume 455, Issue 7216, p.1069-75, (2008) Read More / View Supplemental Materials
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Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.Li, Z., Lu J., Sun M., Mi S., Zhang H., Luo RT, Chen P., Wang Y., Yan M., Qian Z., Neilly MB, Jin J., Zhang Y., Bohlander SK, Zhang DE, Larson RA, Le Beau MM, Thirman MJ, Golub T. R., Rowley JD, et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/10/07, Volume 105, Issue 40, p.15535-40, (2008) Read More / View Supplemental Materials
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Evolutionary toggling of the MAPT 17q21.31 inversion region.Zody, MC, Jiang Z., Fung HC, Antonacci F., Hillier LW, Cardone MF, Graves TA, Kidd JM, Cheng Z., Abouelleil A., Chen L., Wallis J., Glasscock J., Wilson RK, Reily AD, Duckworth J., Ventura M., Hardy J., Warren WC, and Eichler EE Nature genetics, 2008/09/01, Volume 40, Issue 9, p.1076-83, (2008) Read More / View Supplemental Materials
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Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.Tam, WF, Gu TL, Chen J., Lee BH, Bullinger L., Fröhling S., Wang A., Monti S., Golub T. R., and Gilliland DG Blood, 2008/09/01, Volume 112, Issue 5, p.1981-92, (2008) Read More / View Supplemental Materials
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A mitochondrial protein compendium elucidates complex I disease biologyPagliarini, David J., Calvo Sarah E., Chang Betty, Sheth Sunil A., Vafai Scott B., Ong Shao-En, Walford Geoffrey A., Sugiana Canny, Boneh Avihu, Chen William K., Hill David E., Vidal Marc, Evans James G., Thorburn David R., Carr Steven A., and Mootha Vamsi K. Cell, 2008/07/11/, Volume 134, Issue 1, p.112 - 23, (2008) Read More / View Supplemental Materials
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A mitochondrial protein compendium elucidates complex I disease biology.Pagliarini, DJ, Calvo SE, Chang B., Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C., Boneh A., Chen WK, Hill DE, Vidal M., Evans JG, Thorburn DR, Carr SA, and Mootha VK Cell, 2008/07/11, Volume 134, Issue 1, p.112-23, (2008) Read More / View Supplemental Materials
Abstract
Drug-sensitive FGFR2 mutations in endometrial carcinoma.Dutt, A., Salvesen HB, Chen TH, Ramos AH, Onofrio RC, Hatton C., Nicoletti R., Winckler W., Grewal R., Hanna M., Wyhs N., Ziaugra L., Richter DJ, Trovik J., Engelsen IB, Stefansson IM, Fennell T., Cibulskis K., Zody MC, Akslen LA, et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/06/24, Volume 105, Issue 25, p.8713-7, (2008) Read More / View Supplemental Materials
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Mapping and sequencing of structural variation from eight human genomes.Kidd, JM, Cooper GM, Donahue WF, Hayden HS, Sampas N., Graves T., Hansen N., Teague B., Alkan C., Antonacci F., Haugen E., Zerr T., Yamada NA, Tsang P., Newman TL, Tüzün E., Cheng Z., Ebling HM, Tusneem N., David R., et al. Nature, 2008/05/01, Volume 453, Issue 7191, p.56-64, (2008) Read More / View Supplemental Materials
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SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphomaChen, Linfeng, Monti Stefano, Juszczynski Przemyslaw, Daley John, Chen Wen, Witzig Thomas E., Habermann Thomas M., Kutok Jeffery L., and Shipp Margaret A. Blood, 2008/02/15/, Volume 111, Issue 4, p.2230 - 7, (2008) Read More / View Supplemental Materials
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2007
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.Mi, S., Lu J., Sun M., Li Z., Zhang H., Neilly MB, Wang Y., Qian Z., Jin J., Zhang Y., Bohlander SK, Le Beau MM, Larson RA, Golub T. R., Rowley JD, and Chen J. Proceedings of the National Academy of Sciences of the United States of America, 2007/12/11, Volume 104, Issue 50, p.19971-6, (2007) Read More / View Supplemental Materials
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Genome-wide detection and characterization of positive selection in human populations.Sabeti, PC, Varilly P., Fry B., Lohmueller J., Hostetter E., Cotsapas C., Xie X., Byrne EH, McCarroll SA, Gaudet R., Schaffner SF, Lander E. S., International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, et al. Nature, 2007/10/18, Volume 449, Issue 7164, p.913-8, (2007) Read More / View Supplemental Materials
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TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.Plenge, RM, Seielstad M., Padyukov L., Lee AT, Remmers EF, Ding B., Liew A., Khalili H., Chandrasekaran A., Davies LR, Li W., Tan AK, Bonnard C., Ong RT, Thalamuthu A., Pettersson S., Liu C., Tian C., Chen WV, Carulli JP, et al. The New England journal of medicine, 2007/09/20, Volume 357, Issue 12, p.1199-209, (2007) Read More / View Supplemental Materials
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The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphomaJuszczynski, Przemyslaw, Ouyang Jing, Monti Stefano, Rodig Scott J., Takeyama Kunihiko, Abramson Jeremy, Chen Wen, Kutok Jeffery L., Rabinovich Gabriel A., and Shipp Margaret A. Proceedings of the National Academy of Sciences of the United States of America, 2007/08/07/, Volume 104, Issue 32, p.13134 - 9, (2007) Read More / View Supplemental Materials
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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.and of Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes BioMedical Rese, Saxena R., Voight BF, Lyssenko V., Burtt NP, de Bakker PI, Chen H., Roix JJ, Kathiresan S., Hirschhorn JN, Daly M. J., Hughes TE, Groop L., Altshuler D., Almgren P., Florez JC, Meyer J., Ardlie K., Bengtsson Boström K., Isomaa B., et al. Science (New York, N.Y.), 2007/06/01, Volume 316, Issue 5829, p.1331-6, (2007) Read More / View Supplemental Materials
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Prospective isolation and global gene expression analysis of definitive and visceral endoderm.Sherwood, RI, Jitianu C., Cleaver O., Shaywitz DA, Lamenzo JO, Chen AE, Golub T. R., and Melton DA Developmental biology, 2007/04/15, Volume 304, Issue 2, p.541-55, (2007) Read More / View Supplemental Materials
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2006
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.Zody, MC, Garber M., Adams DJ, Sharpe T., Harrow J., Lupski JR, Nicholson C., Searle SM, Wilming L., Young SK, Abouelleil A., Allen NR, Bi W., Bloom T., Borowsky ML, Bugalter BE, Butler J., Chang JL, Chen CK, Cook A., et al. Nature, 2006/04/20, Volume 440, Issue 7087, p.1045-9, (2006) Read More / View Supplemental Materials
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2005
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.Greulich, H., Chen TH, Feng W., Jänne PA, Alvarez JV, Zappaterra M., Bulmer SE, Frank DA, Hahn WC, Sellers WR, and Meyerson M. PLoS medicine, 2005/11/01, Volume 2, Issue 11, p.e313, (2005) Read More / View Supplemental Materials
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NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypesFeuerhake, Friedrich, Kutok Jeffery L., Monti Stefano, Chen Wen, LaCasce Ann S., Cattoretti Giorgio, Kurtin Paul, Pinkus Geraldine S., de Leval Laurence, Harris Nancy L., Savage Kerry J., Neuberg Donna, Habermann Thomas M., Dalla-Favera Riccardo, Golub Todd R., and A Blood, 2005/08/15/, Volume 106, Issue 4, p.1392 - 9, (2005) Read More / View Supplemental Materials
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NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.Feuerhake, F., Kutok JL, Monti S., Chen W., LaCasce AS, Cattoretti G., Kurtin P., Pinkus GS, de Leval L., Harris NL, Savage KJ, Neuberg D., Habermann TM, Dalla-Favera R., Golub T. R., Aster J. C., and Shipp M. A. Blood, 2005/08/15, Volume 106, Issue 4, p.1392-9, (2005) Read More / View Supplemental Materials
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Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysisZhao, Xiaojun, Weir Barbara A., LaFramboise Thomas, Lin Ming, Beroukhim Rameen, Garraway Levi, Beheshti Javad, Lee Jeffrey C., Naoki Katsuhiko, Richards William G., Sugarbaker David, Chen Fei, Rubin Mark A., and J Cancer Research, 2005/07/01/, Volume 65, Issue 13, p.5561 - 70, (2005) Read More / View Supplemental Materials
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Convergent diversity-oriented synthesis of small-molecule hybrids.Chen, C., Li X., Neumann CS, Lo MM, and Schreiber SL Angewandte Chemie (International ed. in English), 2005/04/08, Volume 44, Issue 15, p.2249-52, (2005) Read More / View Supplemental Materials
2004
High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines.Jänne, PA, Li C., Zhao X., Girard L., Chen TH, Minna J., Christiani DC, Johnson B. E., and Meyerson M. Oncogene, 2004/04/08, Volume 23, Issue 15, p.2716-26, (2004) Read More / View Supplemental Materials
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2002
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cellsChen, Chang-Zheng, Li Min, de Graaf David, Monti Stefano, and G Proceedings of the National Academy of Sciences of the United States of America, 2002/11/26/, Volume 99, Issue 24, p.15468 - 73, (2002) Read More / View Supplemental Materials
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