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  • Showing 1-35 of 35 Results
2014
Small-molecule control of cytokine function: new opportunities for treating immune disorders.Sundberg, TB, Xavier RJ, Schreiber SL, and Shamji AF Current opinion in chemical biology, 2014/09/12, Volume 23C, p.23-30, (2014) Read More / View Supplemental Materials
Abstract
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.Kumar, V., Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A., Giamarellos-Bourboulis E., Karjalainen J., Franke L., Withoff S., Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H., Bauer H., Herrmann BG, Bochud PY, Marchetti O., Perfect JR, Xavier RJ, et al. Nature communications, 2014/09/08, Volume 5, p.4675, (2014) Read More / View Supplemental Materials
Abstract
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.Doench, JG, Hartenian E., Graham DB, Tothova Z., Hegde M., Smith I., Sullender M., Ebert BL, Xavier RJ, and Root DE Nature biotechnology, 2014/09/03, (2014) Read More / View Supplemental Materials
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Multivariate inference of pathway activity in host immunity and response to therapeutics.Goel, G., Conway KL, Jaeger M., Netea MG, and Xavier RJ Nucleic acids research, 2014/08/21, (2014) Read More / View Supplemental Materials
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An alteration in ATG16L1 stability in Crohn disease.Lassen, KG, and Xavier RJ Autophagy, 2014/08/12, Volume 10, Issue 10, (2014) Read More / View Supplemental Materials
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.Sundberg, TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B., Gagnon J., O'Connell DJ, Narayan K., Dančík V., Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, and Shamji AF Proceedings of the National Academy of Sciences of the United States of America, 2014/08/11, (2014) Read More / View Supplemental Materials
Abstract
Inflammatory Bowel Disease as a Model for Translating the Microbiome.Huttenhower, C., Kostic AD, and Xavier RJ Immunity, 2014/06/19, Volume 40, Issue 6, p.843-854, (2014) Read More / View Supplemental Materials
Abstract
Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.Tam, JM, Mansour MK, Khan NS, Seward M., Puranam S., Tanne A., Sokolovska A., Becker CE, Acharya M., Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A., Stuart LM, Xavier RJ, and Vyas JM The Journal of infectious diseases, 2014/05/19, (2014) Read More / View Supplemental Materials
Abstract
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.Lassen, KG, Kuballa P., Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L., Horn H., Mercer J., Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly M. J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/05/12, (2014) Read More / View Supplemental Materials
Abstract
The treatment-naive microbiome in new-onset Crohn's disease.Gevers, D., Kugathasan S., Denson LA, Vázquez-Baeza Y., Van Treuren W., Ren B., Schwager E., Knights D., Song SJ, Yassour M., Morgan XC, Kostic AD, Luo C., González A., McDonald D., Haberman Y., Walters T., Baker S., Rosh J., Stephens M., et al. Cell host & microbe, 2014/03/12, Volume 15, Issue 3, p.382-92, (2014) Read More / View Supplemental Materials
Abstract
The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.Kostic, AD, Xavier RJ, and Gevers D. Gastroenterology, 2014/02/18, (2014) Read More / View Supplemental Materials
Abstract
SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.Fowler, SA, Ananthakrishnan AN, Gardet A., Stevens CR, Korzenik JR, Sands BE, Daly M. J., Xavier RJ, and Yajnik V. Journal of Crohn's & colitis, 2014/01/22, (2014) Read More / View Supplemental Materials
Abstract
Autophagy is essential for cardiac morphogenesis during vertebrate development.Lee, E., Koo Y., Ng A., Wei Y., Luby-Phelps K., Juraszek A., Xavier RJ, Cleaver O., Levine B., and Amatruda JF Autophagy, 2014/01/14, Volume 10, Issue 4, (2014) Read More / View Supplemental Materials
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Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.Ananthakrishnan, AN, Huang H., Nguyen DD, Sauk J., Yajnik V., and Xavier RJ The American journal of gastroenterology, 2014/01/14, (2014) Read More / View Supplemental Materials
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2013
Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.Sandoval, GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K., Sammut B., Bhattacharya D., Srivatsan S., Kim A., Shaw AS, Yang-Iott K., Bassing CH, Duncavage E., Xavier RJ, and Swat W. Cancer immunology research, 2013/12/01, Volume 1, Issue 6, p.426-37, (2013) Read More / View Supplemental Materials
Abstract
Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.Knights, D., Lassen KG, and Xavier RJ Gut, 2013/10/01, Volume 62, Issue 10, p.1505-10, (2013) Read More / View Supplemental Materials
Abstract
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.Conway, KL, Kuballa P., Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M., Aldrich LN, Villablanca EJ, Peloquin JM, Goel G., Lee IA, Mizoguchi E., Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, et al. Gastroenterology, 2013/08/21, (2013) Read More / View Supplemental Materials
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From genetics of inflammatory bowel disease towards mechanistic insights.Graham, DB, and Xavier RJ Trends in immunology, 2013/04/29, (2013) Read More / View Supplemental Materials
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Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.Kirby, A., Gnirke A., Jaffe DB, Barešová V., Pochet N., Blumenstiel B., Ye C., Aird D., Stevens C., Robinson JT, Cabili MN, Gat-Viks I., Kelliher E., Daza R., DeFelice M., Hůlková H., Sovová J., Vylet'al P., Antignac C., Guttman M., et al. Nature genetics, 2013/03/01, Volume 45, Issue 3, p.299-303, (2013) Read More / View Supplemental Materials
Abstract
ATG5 regulates plasma cell differentiation.Conway, KL, Kuballa P., Khor B., Zhang M., Shi HN, Virgin HW, and Xavier RJ Autophagy, 2013/01/17, Volume 9, Issue 4, (2013) Read More / View Supplemental Materials
Abstract
2012
The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.Huett, A., Heath RJ, Begun J., Sassi SO, Baxt LA, Vyas JM, Goldberg MB, and Xavier RJ Cell host & microbe, 2012/12/13, Volume 12, Issue 6, p.778-90, (2012) Read More / View Supplemental Materials
Abstract
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.Kleinnijenhuis, J., Quintin J., Preijers F., Joosten LA, Ifrim DC, Saeed S., Jacobs C., van Loenhout J., de Jong D., Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R., and Netea MG Proceedings of the National Academy of Sciences of the United States of America, 2012/10/23, Volume 109, Issue 43, p.17537-42, (2012) Read More / View Supplemental Materials
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p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.Conway, KL, Goel G., Sokol H., Manocha M., Mizoguchi E., Terhorst C., Bhan AK, Gardet A., and Xavier RJ Journal of immunology (Baltimore, Md. : 1950), 2012/10/01, Volume 189, Issue 7, p.3631-40, (2012) Read More / View Supplemental Materials
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Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.Quintin, J., Saeed S., Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C., Jacobs L., Jansen T., Kullberg BJ, Wijmenga C., Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, and Netea MG Cell host & microbe, 2012/08/16, Volume 12, Issue 2, p.223-32, (2012) Read More / View Supplemental Materials
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Genome-wide siRNA screen for mediators of NF-κB activation.Gewurz, BE, Towfic F., Mar JC, Shinners NP, Takasaki K., Zhao B., Cahir-McFarland ED, Quackenbush J., Xavier RJ, and Kieff E. Proceedings of the National Academy of Sciences of the United States of America, 2012/02/14, Volume 109, Issue 7, p.2467-72, (2012) Read More / View Supplemental Materials
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Autophagy and the immune system.Kuballa, P., Nolte WM, Castoreno AB, and Xavier RJ Annual review of immunology, 2012/01/01, Volume 30, p.611-46, (2012) Read More / View Supplemental Materials
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Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.Papa, E., Docktor M., Smillie C., Weber S., Preheim SP, Gevers D., Giannoukos G., Ciulla D., Tabbaa D., Ingram J., Schauer DB, Ward DV, Korzenik JR, Xavier RJ, Bousvaros A., and Alm EJ PloS one, 2012/01/01, Volume 7, Issue 6, p.e39242, (2012) Read More / View Supplemental Materials
Abstract
2011
Image-based genome-wide siRNA screen identifies selective autophagy factors.Orvedahl, A., Sumpter R Jr, Xiao G., Ng A., Zou Z., Tang Y., Narimatsu M., Gilpin C., Sun Q., Roth M., Forst CV, Wrana JL, Zhang YE, Luby-Phelps K., Xavier RJ, Xie Y., and Levine B. Nature, 2011/12/01, Volume 480, Issue 7375, p.113-7, (2011) Read More / View Supplemental Materials
Abstract
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.Rivas, MA, Beaudoin M., Gardet A., Stevens C., Sharma Y., Zhang CK, Boucher G., Ripke S., Ellinghaus D., Burtt N., Fennell T., Kirby A., Latiano A., Goyette P., Green T., Halfvarson J., Haritunians T., Korn JM, Kuruvilla F., Lagacé C., et al. Nature genetics, 2011/10/09, Volume 43, Issue 11, p.1066-73, (2011) Read More / View Supplemental Materials
Abstract
Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.Ng, A., and Xavier RJ Autophagy, 2011/09/01, Volume 7, Issue 9, p.1082-4, (2011) Read More / View Supplemental Materials
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Genetics and pathogenesis of inflammatory bowel disease.Khor, B., Gardet A., and Xavier RJ Nature, 2011/06/15, Volume 474, Issue 7351, p.307-17, (2011) Read More / View Supplemental Materials
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Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.Heath, RJ, Leong JM, Visegrády B., Machesky LM, and Xavier RJ PLoS pathogens, 2011/04/01, Volume 7, Issue 4, p.e1001332, (2011) Read More / View Supplemental Materials
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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.Rossin, EJ, Lage K., Raychaudhuri S., Xavier RJ, Tatar D., Benita Y., International Inflammatory Bowel Disease Genetics Constortium, Cotsapas C., and Daly M. J. PLoS genetics, 2011/01/13, Volume 7, Issue 1, p.e1001273, (2011) Read More / View Supplemental Materials
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2010
LRRK2 is involved in the IFN-gamma response and host response to pathogens.Gardet, A., Benita Y., Li C., Sands BE, Ballester I., Stevens C., Korzenik JR, Rioux JD, Daly M. J., Xavier RJ, and Podolsky DK Journal of immunology (Baltimore, Md. : 1950), 2010/11/01, Volume 185, Issue 9, p.5577-85, (2010) Read More / View Supplemental Materials
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2009
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.Raychaudhuri, S., Plenge RM, Rossin EJ, Ng AC, International Schizophrenia Consortium, Purcell SM, Sklar P., Scolnick EM, Xavier RJ, Altshuler D., and Daly M. J. PLoS genetics, 2009/06/01, Volume 5, Issue 6, p.e1000534, (2009) Read More / View Supplemental Materials
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  • Showing 1-35 of 35 Results