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  • Showing 1-7 of 7 Results
2016
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.Wagner, FF, Weïwer M., Steinbacher S., Schomburg A., Reinemer P., Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M., Müller P., Jefson MR, Fass DM, Haggarty SJ, Zhang YL, and Holson EB Bioorganic & medicinal chemistry, 2016/06/22, (2016) Read More / View Supplemental Materials
Abstract
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.Wagner, FF, Lundh M., Kaya T., McCarren P., Zhang YL, Chattopadhyay S., Gale JP, Galbo T., Fisher SL, Meier BC, Vetere A., Richardson S., Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M., Walpita D., Mandrup-Poulsen T., Wagner BK, et al. ACS chemical biology, 2016/02/19, Volume 11, Issue 2, p.363-74, (2016) Read More / View Supplemental Materials
Abstract
2015
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.Olson, DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, and Holson EB Chemistry & biology, 2015/04/23, Volume 22, Issue 4, p.439-45, (2015) Read More / View Supplemental Materials
Abstract
Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.Wagner, FF, Zhang YL, Fass DM, Joseph N., Gale JP, Weïwer M., McCarren P., Fisher SL, Kaya T., Zhao WN, Reis SA, Hennig KM, Thomas M., Lemercier BC, Lewis MC, Guan JS, Moyer MP, Scolnick E., Haggarty SJ, Tsai LH, et al. Chemical science (Royal Society of Chemistry : 2010), 2015/01/01, Volume 6, Issue 1, p.804-815, (2015) Read More / View Supplemental Materials
Abstract
2014
An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.Olson, DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T., Natoli T., Lu X., Paulk J., McCarren P., Wagner FF, Barker D., Howe E., Lazzaro F., Gale JP, Zhang YL, Subramanian A., Fierke CA, Carr SA, et al. ACS chemical biology, 2014/10/17, Volume 9, Issue 10, p.2210-6, (2014) Read More / View Supplemental Materials
Abstract
2013
Discovery of the first histone deacetylase 6/8 dual inhibitors.Olson, DE, Wagner FF, Kaya T., Gale JP, Aidoud N., Davoine EL, Lazzaro F., Weïwer M., Zhang YL, and Holson EB Journal of medicinal chemistry, 2013/06/13, Volume 56, Issue 11, p.4816-20, (2013) Read More / View Supplemental Materials
Abstract
Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif.Wagner, FF, Olson DE, Gale JP, Kaya T., Weïwer M., Aidoud N., Thomas M., Davoine EL, Lemercier BC, Zhang YL, and Holson EB Journal of medicinal chemistry, 2013/02/18, (2013) Read More / View Supplemental Materials
Abstract
  • Showing 1-7 of 7 Results