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2014
Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden.Frisell, T., Hellgren K., Alfredsson L., Raychaudhuri S., Klareskog L., and Askling J. Annals of the rheumatic diseases, 2014/12/12, (2014) Read More / View Supplemental Materials
Abstract
A role for noncoding variation in schizophrenia.Roussos, P., Mitchell AC, Voloudakis G., Fullard JF, Pothula VM, Tsang J., Stahl EA, Georgakopoulos A., Ruderfer DM, Charney A., Okada Y., Siminovitch KA, Worthington J., Padyukov L., Klareskog L., Gregersen PK, Plenge RM, Raychaudhuri S., Fromer M., Purcell SM, et al. Cell reports, 2014/11/20, Volume 9, Issue 4, p.1417-29, (2014) Read More / View Supplemental Materials
Abstract
Variation at HLA-DRB1 is associated with resistance to enteric fever.Dunstan, SJ, Hue NT, Han B., Li Z., Tram TT, Sim KS, Parry CM, Chinh NT, Vinh H., Lan NP, Thieu NT, Vinh PV, Koirala S., Dongol S., Arjyal A., Karkey A., Shilpakar O., Dolecek C., Foo JN, Phuong LT, et al. Nature genetics, 2014/11/10, (2014) Read More / View Supplemental Materials
Abstract
A Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity.Lim, ET, Liu YP, Chan Y., Tiinamaija T., Käräjämäki A., Madsen E., Go-T2D Consortium, Altshuler DM, Raychaudhuri S., Groop L., Flannick J., Hirschhorn JN, Katsanis N., and Daly M. J. American journal of human genetics, 2014/11/06, Volume 95, Issue 5, p.509-20, (2014) Read More / View Supplemental Materials
Abstract
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.Gusev, A., Lee SH, Trynka G., Finucane H., Vilhjálmsson BJ, Xu H., Zang C., Ripke S., Bulik-Sullivan B., Stahl E., Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M., Pasaniuc B., Sullivan PF, Neale BM, et al. American journal of human genetics, 2014/11/06, Volume 95, Issue 5, p.535-52, (2014) Read More / View Supplemental Materials
Abstract
Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.Okada, Y., Han B., Tsoi LC, Stuart PE, Ellinghaus E., Tejasvi T., Chandran V., Pellett F., Pollock R., Bowcock AM, Krueger GG, Weichenthal M., Voorhees JJ, Rahman P., Gregersen PK, Franke A., Nair RP, Abecasis GR, Gladman DD, Elder JT, et al. American journal of human genetics, 2014/08/07, Volume 95, Issue 2, p.162-72, (2014) Read More / View Supplemental Materials
Abstract
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.Okada, Y., Kim K., Han B., Pillai NE, Ong RT, Saw WY, Luo M., Jiang L., Yin J., Bang SY, Lee HS, Brown MA, Bae SC, Xu H., Teo YY, de Bakker PI, and Raychaudhuri S. Human molecular genetics, 2014/07/28, (2014) Read More / View Supplemental Materials
Abstract
Genetic variants in the complement system predisposing to age-related macular degeneration: A review.Schramm, EC, Clark SJ, Triebwasser MP, Raychaudhuri S., Seddon JM, and Atkinson JP Molecular immunology, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.Arking, DE, Pulit SL, Crotti L., van der Harst P., Munroe PB, Koopmann TT, Sotoodehnia N., Rossin EJ, Morley M., Wang X., Johnson AD, Lundby A., Gudbjartsson DF, Noseworthy PA, Eijgelsheim M., Bradford Y., Tarasov KV, Dörr M., Müller-Nurasyid M., Lahtinen AM, et al. Nature genetics, 2014/06/22, (2014) Read More / View Supplemental Materials
Abstract
Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells.Hu, X., Im HK, Raj T., Brennan PJ, Trynka G., Teslovich N., Slowikowski K., Chen WM, Onengut S., Baecher-Allan C., De Jager PL, Rich SS, Stranger BE, Brenner MB, and Raychaudhuri S. PLoS genetics, 2014/06/01, Volume 10, Issue 6, p.e1004404, (2014) Read More / View Supplemental Materials
Abstract
Whole -exome sequencing identifies rare, functional CFH variants in families with macular degeneration.Yu, Y., Triebwasser MP, Wong EK, Schramm EC, Thomas B., Reynolds R., Mardis E., Atkinson JP, Daly M., Raychaudhuri S., Kavanagh D., and Seddon JM Human molecular genetics, 2014/05/20, (2014) Read More / View Supplemental Materials
Abstract
Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity.Han, B., Diogo D., Eyre S., Kallberg H., Zhernakova A., Bowes J., Padyukov L., Okada Y., González-Gay MA, Rantapää-Dahlqvist S., Martin J., Huizinga TW, Plenge RM, Worthington J., Gregersen PK, Klareskog L., de Bakker PI, and Raychaudhuri S. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.522-32, (2014) Read More / View Supplemental Materials
Abstract
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
Abstract
Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene.Okada, Y., Diogo D., Greenberg JD, Mouassess F., Achkar WA, Fulton RS, Denny JC, Gupta N., Mirel D., Gabriel S., Li G., Kremer JM, Pappas DA, Carroll RJ, Eyler AE, Trynka G., Stahl EA, Cui J., Saxena R., Coenen MJ, et al. PloS one, 2014/01/01, Volume 9, Issue 2, p.e87645, (2014) Read More / View Supplemental Materials
Abstract
2013
Genetics of rheumatoid arthritis contributes to biology and drug discovery.Okada, Y., Wu D., Trynka G., Raj T., Terao C., Ikari K., Kochi Y., Ohmura K., Suzuki A., Yoshida S., Graham RR, Manoharan A., Ortmann W., Bhangale T., Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
Abstract
Quantifying Missing Heritability at Known GWAS Loci.Gusev, A., Bhatia G., Zaitlen N., Vilhjalmsson BJ, Diogo D., Stahl EA, Gregersen PK, Worthington J., Klareskog L., Raychaudhuri S., Plenge RM, Pasaniuc B., and Price AL PLoS genetics, 2013/12/01, Volume 9, Issue 12, p.e1003993, (2013) Read More / View Supplemental Materials
Abstract
Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases.Trynka, G., and Raychaudhuri S. Current opinion in genetics & development, 2013/12/01, Volume 23, Issue 6, p.635-41, (2013) Read More / View Supplemental Materials
Abstract
Fast Pairwise IBD Association Testing in Genome-wide Association Studies.Han, B., Kang EY, Raychaudhuri S., de Bakker PI, and Eskin E. Bioinformatics (Oxford, England), 2013/10/24, (2013) Read More / View Supplemental Materials
Abstract
Common risk alleles for inflammatory diseases are targets of recent positive selection.Raj, T., Kuchroo M., Replogle JM, Raychaudhuri S., Stranger BE, and De Jager PL American journal of human genetics, 2013/04/04, Volume 92, Issue 4, p.517-29, (2013) Read More / View Supplemental Materials
Abstract
Chromatin marks identify critical cell types for fine mapping complex trait variants.Trynka, G., Sandor C., Han B., Xu H., Stranger BE, Liu XS, and Raychaudhuri S. Nature genetics, 2013/02/01, Volume 45, Issue 2, p.124-30, (2013) Read More / View Supplemental Materials
Abstract
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.Lim, ET, Raychaudhuri S., Sanders SJ, Stevens C., Sabo A., Macarthur DG, Neale BM, Kirby A., Ruderfer DM, Fromer M., Lek M., Liu L., Flannick J., Ripke S., Nagaswamy U., Muzny D., Reid JG, Hawes A., Newsham I., Wu Y., et al. Neuron, 2013/01/23, Volume 77, Issue 2, p.235-42, (2013) Read More / View Supplemental Materials
Abstract
Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis.Diogo, D., Kurreeman F., Stahl EA, Liao KP, Gupta N., Greenberg JD, Rivas MA, Hickey B., Flannick J., Thomson B., Guiducci C., Ripke S., Adzhubey I., Barton A., Kremer JM, Alfredsson L., Consortium of Rheumatology Researchers of North America, Rheumatoid Arthritis Consortium International, Sunyaev S., Martin J., et al. American journal of human genetics, 2013/01/10, Volume 92, Issue 1, p.15-27, (2013) Read More / View Supplemental Materials
Abstract
2012
Autoimmunity: insights from human genomics.Raychaudhuri, S., and Rich SS Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.513-5, (2012) Read More / View Supplemental Materials
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.Stahl, EA, Wegmann D., Trynka G., Gutierrez-Achury J., Do R., Voight BF, Kraft P., Chen R., Kallberg HJ, Kurreeman FA, Diabetes Genetics Replication and Meta-analysis Consortium, Myocardial Infarction Genetics Consortium, Kathiresan S., Wijmenga C., Gregersen PK, Alfredsson L., Siminovitch KA, Worthington J., de Bakker PI, Raychaudhuri S., et al. Nature genetics, 2012/03/25, (2012) Read More / View Supplemental Materials
Abstract
Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12.Kurreeman, FA, Stahl EA, Okada Y., Liao K., Diogo D., Raychaudhuri S., Freudenberg J., Kochi Y., Patsopoulos NA, Gupta N., investigators CLEAR, Sandor C., Bang SY, Lee HS, Padyukov L., Suzuki A., Siminovitch K., Worthington J., Gregersen PK, Hughes LB, et al. American journal of human genetics, 2012/03/09, Volume 90, Issue 3, p.524-532, (2012) Read More / View Supplemental Materials
Abstract
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.Raychaudhuri, S., Sandor C., Stahl EA, Freudenberg J., Lee HS, Jia X., Alfredsson L., Padyukov L., Klareskog L., Worthington J., Siminovitch KA, Bae SC, Plenge RM, Gregersen PK, and de Bakker PI Nature genetics, 2012/01/29, Volume 44, Issue 3, p.291-6, (2012) Read More / View Supplemental Materials
Abstract
2011
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration.Raychaudhuri, S., Iartchouk O., Chin K., Tan PL, Tai AK, Ripke S., Gowrisankar S., Vemuri S., Montgomery K., Yu Y., Reynolds R., Zack DJ, Campochiaro B., Campochiaro P., Katsanis N., Daly M. J., and Seddon JM Nature genetics, 2011/10/23, Volume 43, Issue 12, p.1232-6, (2011) Read More / View Supplemental Materials
Abstract
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.Rossin, EJ, Lage K., Raychaudhuri S., Xavier RJ, Tatar D., Benita Y., International Inflammatory Bowel Disease Genetics Constortium, Cotsapas C., and Daly M. J. PLoS genetics, 2011/01/13, Volume 7, Issue 1, p.e1001273, (2011) Read More / View Supplemental Materials
Abstract
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.Kurreeman, F., Liao K., Chibnik L., Hickey B., Stahl E., Gainer V., Li G., Bry L., Mahan S., Ardlie K., Thomson B., Szolovits P., Churchill S., Murphy SN, Cai T., Raychaudhuri S., Kohane I., Karlson E., and Plenge RM American journal of human genetics, 2011/01/07, Volume 88, Issue 1, p.57-69, (2011) Read More / View Supplemental Materials
Abstract
2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Speliotes, EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G., Jackson AU, Allen HL, Lindgren CM, Luan J., Mägi R., Randall JC, Vedantam S., Winkler TW, Qi L., Workalemahu T., Heid IM, Steinthorsdottir V., Stringham HM, Weedon MN, Wheeler E., et al. Nature genetics, 2010/11/01, Volume 42, Issue 11, p.937-48, (2010) Read More / View Supplemental Materials
Abstract
Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.Raychaudhuri, S., Korn JM, McCarroll SA, International Schizophrenia Consortium, Altshuler D., Sklar P., Purcell S., and Daly M. J. PLoS genetics, 2010/09/09, Volume 6, Issue 9, (2010) Read More / View Supplemental Materials
Abstract
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Voight, BF, Scott LJ, Steinthorsdottir V., Morris AP, Dina C., Welch RP, Zeggini E., Huth C., Aulchenko YS, Thorleifsson G., McCulloch LJ, Ferreira T., Grallert H., Amin N., Wu G., Willer CJ, Raychaudhuri S., McCarroll SA, Langenberg C., Hofmann OM, et al. Nature genetics, 2010/07/01, Volume 42, Issue 7, p.579-89, (2010) Read More / View Supplemental Materials
Abstract
The landscape of somatic copy-number alteration across human cancers.Beroukhim, R., Mermel CH, Porter D., Wei G., Raychaudhuri S., Donovan J., Barretina J., Boehm JS, Dobson J., Urashima M., Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L., Greulich H., Reich M., Winckler W., Lawrence MS, Weir BA, et al. Nature, 2010/02/18, Volume 463, Issue 7283, p.899-905, (2010) Read More / View Supplemental Materials
Abstract
2009
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.Raychaudhuri, S., Plenge RM, Rossin EJ, Ng AC, International Schizophrenia Consortium, Purcell SM, Sklar P., Scolnick EM, Xavier RJ, Altshuler D., and Daly M. J. PLoS genetics, 2009/06/01, Volume 5, Issue 6, p.e1000534, (2009) Read More / View Supplemental Materials
Abstract
2008
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.Raychaudhuri, S., Remmers EF, Lee AT, Hackett R., Guiducci C., Burtt NP, Gianniny L., Korman BD, Padyukov L., Kurreeman FA, Chang M., Catanese JJ, Ding B., Wong S., van der Helm-van Mil AH, Neale BM, Coblyn J., Cui J., Tak PP, Wolbink GJ, et al. Nature genetics, 2008/10/01, Volume 40, Issue 10, p.1216-23, (2008) Read More / View Supplemental Materials
Abstract
  • Showing 1-35 of 35 Results