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  • Showing 1-16 of 16 Results
2016
Health and population effects of rare gene knockouts in adult humans with related parents.Narasimhan, VM, Hunt KA, Mason D., Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C., Bellary S., Bockett NA, Giorda K., Griffiths CJ, Hemingway H., Jia Z., Kelly MA, Khawaja HA, Lek M., McCarthy S., McEachan R., O'Donnell-Luria A., et al. Science (New York, N.Y.), 2016/03/03, (2016) Read More / View Supplemental Materials
Abstract
A homozygous nonsense mutation in SGCA is a common cause of LGMD in Assiut, Egypt.Reddy, HM, Hamed SA, Lek M., Mitsuhashi S., Estrella E., Jones MD, Mahoney LJ, Duncan AR, Cho K., Macarthur DG, Kunkel LM, and Kang PB Muscle & nerve, 2016/03/02, (2016) Read More / View Supplemental Materials
Abstract
Prominent scapulae mimicking an inherited myopathy expands the phenotype of CHD7-related disease.O'Grady, GL, Ma A., Sival D., Wong MT, Peduto T., Menezes MP, Young H., Waddell L., Ghaoui R., Needham M., Lek M., North KN, Macarthur DG, van Ravenswaaij-Arts CM, and Clarke NF European journal of human genetics : EJHG, 2016/01/27, (2016) Read More / View Supplemental Materials
Abstract
Quantifying prion disease penetrance using large population control cohorts.Minikel, EV, Vallabh SM, Lek M., Estrada K., Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LP, Gambetti P., Blevins J., Zhang S., Cohen Y., Chen W., Yamada M., Hamaguchi T., Sanjo N., Mizusawa H., Nakamura Y., Kitamoto T., et al. Science translational medicine, 2016/01/20, Volume 8, Issue 322, p.322ra9, (2016) Read More / View Supplemental Materials
Abstract
2015
Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy.Ghaoui, R., Palmio J., Brewer J., Lek M., Needham M., Evilä A., Hackman P., Jonson PH, Penttilä S., Vihola A., Huovinen S., Lindfors M., Davis RL, Waddell L., Kaur S., Yiannikas C., North K., Clarke N., Macarthur DG, Sue CM, et al. Neurology, 2015/12/30, (2015) Read More / View Supplemental Materials
Abstract
Analysis of the ACTN3 Heterozygous Genotype Suggests That α-Actinin-3 Controls Sarcomeric Composition and Muscle Function in a Dose-Dependent Fashion.Hogarth, MW, Garton FC, Houweling PJ, Tukiainen T., Lek M., Macarthur DG, Seto JT, Quinlan KG, Yang N., Head SI, and North KN Human molecular genetics, 2015/12/17, (2015) Read More / View Supplemental Materials
Abstract
Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.Li, YR, van Setten J., Verma SS, Lu Y., Holmes MV, Gao H., Lek M., Nair N., Chandrupatla H., Chang B., Karczewski KJ, Wong C., Mohebnasab M., Mukhtar E., Phillips R., Tragante V., Hou C., Steel L., Lee T., Garifallou J., et al. Genome medicine, 2015/10/01, Volume 7, Issue 1, p.90, (2015) Read More / View Supplemental Materials
Abstract
Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol (GPI) deficiencies.Ilkovski, B., Pagnamenta AT, O'Grady GL, Kinoshita T., Howard MF, Lek M., Thomas B., Turner A., Christodoulou J., Sillence D., Knight SJ, Popitsch N., Keays DA, Anzilotti C., Goriely A., Waddell LB, Brilot F., North KN, Kanzawa N., Macarthur DG, et al. Human molecular genetics, 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Human genomics. Effect of predicted protein-truncating genetic variants on the human transcriptome.Rivas, MA, Pirinen M., Conrad DF, Lek M., Tsang EK, Karczewski KJ, Maller JB, Kukurba KR, Deluca DS, Fromer M., Ferreira PG, Smith KS, Zhang R., Zhao F., Banks E., Poplin R., Ruderfer DM, Purcell SM, Tukiainen T., Minikel EV, et al. Science (New York, N.Y.), 2015/05/08, Volume 348, Issue 6235, p.666-9, (2015) Read More / View Supplemental Materials
Abstract
Expanding the phenotype of GMPPB mutations.Cabrera-Serrano, M., Ghaoui R., Ravenscroft G., Johnsen RD, Davis MR, Corbett A., Reddel S., Sue CM, Liang C., Waddell LB, Kaur S., Lek M., North KN, Macarthur DG, Lamont PJ, Clarke NF, and Laing NG Brain : a journal of neurology, 2015/02/12, (2015) Read More / View Supplemental Materials
Abstract
2014
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Goldstein, JI, Fredrik Jarskog L., Hilliard C., Alfirevic A., Duncan L., Fourches D., Huang H., Lek M., Neale BM, Ripke S., Shianna K., Szatkiewicz JP, Tropsha A., van den Oord EJ, Cascorbi I., Dettling M., Gazit E., Goff DC, Holden AL, Kelly DL, et al. Nature communications, 2014/09/04, Volume 5, p.4757, (2014) Read More / View Supplemental Materials
Abstract
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.Lim, ET, Würtz P., Havulinna AS, Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem RM, Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004494, (2014) Read More / View Supplemental Materials
Abstract
Allelic Expression of Deleterious Protein-Coding Variants across Human Tissues.Kukurba, KR, Zhang R., Li X., Smith KS, Knowles DA, How Tan M., Piskol R., Lek M., Snyder M., Macarthur DG, Li JB, and Montgomery SB PLoS genetics, 2014/05/01, Volume 10, Issue 5, p.e1004304, (2014) Read More / View Supplemental Materials
Abstract
Biallelic Variants in TTLL5, Encoding a Tubulin Glutamylase, Cause Retinal Dystrophy.Sergouniotis, PI, Chakarova C., Murphy C., Becker M., Lenassi E., Arno G., Lek M., Macarthur DG, UCL-Exomes Consortium, Bhattacharya SS, Moore AT, Holder GE, Robson AG, Wolfrum U., Webster AR, and Plagnol V. American journal of human genetics, 2014/05/01, Volume 94, Issue 5, p.760-9, (2014) Read More / View Supplemental Materials
Abstract
2013
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.Lim, ET, Raychaudhuri S., Sanders SJ, Stevens C., Sabo A., Macarthur DG, Neale BM, Kirby A., Ruderfer DM, Fromer M., Lek M., Liu L., Flannick J., Ripke S., Nagaswamy U., Muzny D., Reid JG, Hawes A., Newsham I., Wu Y., et al. Neuron, 2013/01/23, Volume 77, Issue 2, p.235-42, (2013) Read More / View Supplemental Materials
Abstract
2012
The uncertain road towards genomic medicine.Macarthur, DG, and Lek M. Trends in genetics : TIG, 2012/07/01, Volume 28, Issue 7, p.303-5, (2012) Read More / View Supplemental Materials
Abstract
  • Showing 1-16 of 16 Results