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2016
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.Scott, RA, Freitag DF, Li L., Chu AY, Surendran P., Young R., Grarup N., Stancáková A., Chen Y., Varga TV, Yaghootkar H., Luan J., Zhao JH, Willems SM, Wessel J., Wang S., Maruthur N., Michailidou K., Pirie A., van der Lee SJ, et al. Science translational medicine, 2016/06/01, Volume 8, Issue 341, p.341ra76, (2016) Read More / View Supplemental Materials
Abstract
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.Raffan, E., Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E., Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, Withers E., Söder J., Wernersson S., Andersson G., Lindblad-Toh K., et al. Cell metabolism, 2016/05/02, (2016) Read More / View Supplemental Materials
Abstract
Physical and neurobehavioral determinants of reproductive onset and success.Day, FR, Helgason H., Chasman DI, Rose LM, Loh PR, Scott RA, Helgason A., Kong A., Masson G., Magnusson OT, Gudbjartsson D., Thorsteinsdottir U., Buring JE, Ridker PM, Sulem P., Stefansson K., Ong KK, and Perry JR Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
A Robust Example of Collider Bias in a Genetic Association Study.Day, FR, Loh PR, Scott RA, Ong KK, and Perry JR American journal of human genetics, 2016/02/04, Volume 98, Issue 2, p.392-3, (2016) Read More / View Supplemental Materials
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.Kilpeläinen, TO, Carli JF, Skowronski AA, Sun Q., Kriebel J., Feitosa MF, Hedman Å. K., Drong AW, Hayes JE, Zhao J., Pers TH, Schick U., Grarup N., Kutalik Z., Trompet S., Mangino M., Kristiansson K., Beekman M., Lyytikäinen LP, Eriksson J., et al. Nature communications, 2016/02/01, Volume 7, p.10494, (2016) Read More / View Supplemental Materials
Abstract
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Lu, Y., Day FR, Gustafsson S., Buchkovich ML, Na J., Bataille V., Cousminer DL, Dastani Z., Drong AW, Esko T., Evans DM, Falchi M., Feitosa MF, Ferreira T., Hedman Å. K., Haring R., Hysi PG, Iles MM, Justice AE, Kanoni S., et al. Nature communications, 2016/02/01, Volume 7, p.10495, (2016) Read More / View Supplemental Materials
Abstract
A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans.Clapham, KR, Chu AY, Wessel J., Natarajan P., Flannick J., Rivas MA, Sartori S., Mehran R., Baber U., Fuster V., Scott RA, Rader DJ, Boehnke M., McCarthy MI, Altshuler DM, Kathiresan S., and Peloso GM BMC endocrine disorders, 2016/01/28, Volume 16, Issue 1, p.7, (2016) Read More / View Supplemental Materials
Abstract
2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.Gaulton, KJ, Ferreira T., Lee Y., Raimondo A., Mägi R., Reschen ME, Mahajan A., Locke A., William Rayner N., Robertson N., Scott RA, Prokopenko I., Scott LJ, Green T., Sparso T., Thuillier D., Yengo L., Grallert H., Wahl S., Frånberg M., et al. Nature genetics, 2015/11/09, (2015) Read More / View Supplemental Materials
Abstract
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.Day, FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N., Chasman DI, Stolk L., Finucane HK, Sulem P., Bulik-Sullivan B., Esko T., Johnson AD, Elks CE, Franceschini N., He C., Altmaier E., Brody JA, Franke LL, Huffman JE, Keller MF, et al. Nature genetics, 2015/11/01, Volume 47, Issue 11, p.1294-303, (2015) Read More / View Supplemental Materials
Abstract
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.Winkler, TW, Justice AE, Graff M., Barata L., Feitosa MF, Chu S., Czajkowski J., Esko T., Fall T., Kilpeläinen TO, Lu Y., Mägi R., Mihailov E., Pers TH, Rüeger S., Teumer A., Ehret GB, Ferreira T., Heard-Costa NL, Karjalainen J., et al. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005378, (2015) Read More / View Supplemental Materials
Abstract
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.Kato, N., Loh M., Takeuchi F., Verweij N., Wang X., Zhang W., Kelly TN, Saleheen D., Lehne B., Leach IM, Drong AW, Abbott J., Wahl S., Tan ST, Scott WR, Campanella G., Chadeau-Hyam M., Afzal U., Ahluwalia TS, Bonder MJ, et al. Nature genetics, 2015/09/21, (2015) Read More / View Supplemental Materials
Abstract
Rare coding variants and X-linked loci associated with age at menarche.Lunetta, KL, Day FR, Sulem P., Ruth KS, Tung JY, Hinds DA, Esko T., Elks CE, Altmaier E., He C., Huffman JE, Mihailov E., Porcu E., Robino A., Rose LM, Schick UM, Stolk L., Teumer A., Thompson DJ, Traglia M., et al. Nature communications, 2015/08/04, Volume 6, p.7756, (2015) Read More / View Supplemental Materials
Abstract
Directional dominance on stature and cognition in diverse human populations.Joshi, PK, Esko T., Mattsson H., Eklund N., Gandin I., Nutile T., Jackson AU, Schurmann C., Smith AV, Zhang W., Okada Y., Stančáková A., Faul JD, Zhao W., Bartz TM, Concas MP, Franceschini N., Enroth S., Vitart V., Trompet S., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
Abstract
New genetic loci link adipose and insulin biology to body fat distribution.Shungin, D., Winkler TW, Croteau-Chonka DC, Ferreira T., Locke AE, Mägi R., Strawbridge RJ, Pers TH, Fischer K., Justice AE, Workalemahu T., Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C., Gustafsson S., Day FR, Esko T., et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.187-96, (2015) Read More / View Supplemental Materials
Abstract
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Wessel, J., Chu AY, Willems SM, Wang S., Yaghootkar H., Brody JA, Dauriz M., Hivert MF, Raghavan S., Lipovich L., Hidalgo B., Fox K., Huffman JE, An P., Lu Y., Rasmussen-Torvik LJ, Grarup N., Ehm MG, Li L., Baldridge AS, et al. Nature communications, 2015/01/29, Volume 6, p.5897, (2015) Read More / View Supplemental Materials
Abstract
2014
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.Benyamin, B., Esko T., Ried JS, Radhakrishnan A., Vermeulen SH, Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra HJ, Franke L., Mihailov E., Milani L., et al. Nature communications, 2014/10/29, Volume 5, p.4926, (2014) Read More / View Supplemental Materials
Abstract
Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
Abstract
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.Swerdlow, DI, Preiss D., Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T., Sofat R., Stender S., Johnson PC, Scott RA, Leusink M., Verweij N., Sharp SJ, Guo Y., Giambartolomei C., Chung C., Peasey A., Amuzu A., Li K., Palmen J., et al. Lancet, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.Hoggart, CJ, Venturini G., Mangino M., Gomez F., Ascari G., Zhao JH, Teumer A., Winkler TW, Tšernikova N., Luan J., Mihailov E., Ehret GB, Zhang W., Lamparter D., Esko T., Macé A., Rüeger S., Bochud PY, Barcella M., Dauvilliers Y., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004508, (2014) Read More / View Supplemental Materials
Abstract
2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Manning, AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N., Chen H., Rybin D., Liu CT, Bielak LF, Prokopenko I., Amin N., Barnes D., Cadby G., Hottenga JJ, Ingelsson E., Jackson AU, Johnson T., Kanoni S., Ladenvall C., Lagou V., et al. Nature genetics, 2012/05/13, Volume 44, Issue 6, p.659-669, (2012) Read More / View Supplemental Materials
Abstract
  • Showing 1-21 of 21 Results