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  • Showing 1-30 of 30 Results
2013
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.Germain, AR, Carmody LC, Nag PP, Morgan B., VerPlank L., Fernandez C., Donckele E., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2013/03/15, Volume 23, Issue 6, p.1834-8, (2013) Read More / View Supplemental Materials
Abstract
2012
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Weïwer, M., Spoonamore J., Wei J., Guichard B., Ross NT, Masson K., Silkworth W., Dandapani S., Palmer M., Scherer CA, Stern AM, Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2012/12/13, Volume 3, Issue 12, p.1034-1038, (2012) Read More / View Supplemental Materials
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Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Dockendorff, C., Nagiec MM, Weïwer M., Buhrlage S., Ting A., Nag PP, Germain A., Kim HJ, Youngsaye W., Scherer C., Bennion M., Xue L., Stanton BZ, Lewis TA, Macpherson L., Palmer M., Foley MA, Perez JR, and Schreiber SL ACS medicinal chemistry letters, 2012/10/11, Volume 3, Issue 10, p.808-813, (2012) Read More / View Supplemental Materials
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Identification of a selective small molecule inhibitor of breast cancer stem cells.Germain, AR, Carmody LC, Morgan B., Fernandez C., Forbeck E., Lewis TA, Nag PP, Ting A., VerPlank L., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/15, Volume 22, Issue 10, p.3571-4, (2012) Read More / View Supplemental Materials
Abstract
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.Youngsaye, W., Dockendorff C., Vincent B., Hartland CL, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/01, Volume 22, Issue 9, p.3362-5, (2012) Read More / View Supplemental Materials
Abstract
Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.Dockendorff, C., Aisiku O., VerPlank L., Dilks JR, Smith DA, Gunnink SF, Dowal L., Negri J., Palmer M., Macpherson L., Schreiber SL, and Flaumenhaft R. ACS medicinal chemistry letters, 2012/03/08, Volume 3, Issue 3, p.232-237, (2012) Read More / View Supplemental Materials
Abstract
Development of small-molecule probes that selectively kill cells induced to express mutant RAS.Weïwer, M., Bittker JA, Lewis TA, Shimada K., Yang WS, Macpherson L., Dandapani S., Palmer M., Stockwell BR, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/02/15, Volume 22, Issue 4, p.1822-6, (2012) Read More / View Supplemental Materials
Abstract
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.Heidebrecht RW, Jr, Mulrooney C., Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E., Dandapani S., Dick J., Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M., Guha R., Hinkson P., Kramer M., Lukens AK, Masi D., Marcaurelle LA, et al. ACS medicinal chemistry letters, 2012/02/09, Volume 3, Issue 2, p.112-117, (2012) Read More / View Supplemental Materials
Abstract
Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of a small molecule that selectively activates alpha-synuclein translational expressionRoss, NT, Metkar SR, Le H., Burbank J., Cahill C., Germain A., Macpherson L., Bittker J., Palmer M., Rogers J., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of a small molecule that selectively inhibits alpha-synuclein translational expressionRoss, NT, Metkar SR, Le H., Burbank J., Cahill C., Germain A., Macpherson L., Bittker J., Palmer M., Rogers J., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet CellsFaloon, PW, Chou DHC, Forbeck EM, Walpita D., Morgan B., Buhrlage S., Ting A., Perez J., MacPherson LJ, Duvall JR, Dandapani S., Marcaurelle LA, Munoz B., Palmer M., Foley M., Wagner B., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1An, WF, Metkar SR, Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2An, WF, Metkar SR, Lewis TA, Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3An, WF, Metkar SR, Youngsaye W., Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small-Molecule Inhibitors of Trypansoma cruzi InfectionCarmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1Carmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3Carmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
2011
Identification of small-molecule inhibitors of Trypansoma cruzi replication.Germain, AR, Carmody LC, Dockendorff C., Galan-Rodriguez C., Rodriguez A., Johnston S., Bittker JA, Macpherson L., Dandapani S., Palmer M., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2011/12/01, Volume 21, Issue 23, p.7197-200, (2011) Read More / View Supplemental Materials
Abstract
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.Youngsaye, W., Vincent B., Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S., Bittker JA, Macpherson L., Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2011/09/15, Volume 21, Issue 18, p.5502-5, (2011) Read More / View Supplemental Materials
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2010
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Marcaurelle, LA, Comer E., Dandapani S., Duvall JR, Gerard B., Kesavan S., Lee MD 4th, Liu H., Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A., Ryba TD, Suh BC, Wei J., Young DW, Akella LB, Ross NT, Zhang YL, et al. Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.16962-76, (2010) Read More / View Supplemental Materials
Abstract
Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials
Screen for RAS-Selective Lethal Compounds and VDAC LigandsBittker, JA, Weiwer M., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/03/26, (2010) Read More / View Supplemental Materials
Abstract
Discovery of Inhibitors of Anti-Apoptotic Protein A1Bittker, JA, Weiwer M., Wei G., Germain A., Brown E., Dandapani S., Munoz B., Palmer M., Golub T., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2Hartland, CL, Youngsaye W., Morgan B., Ting A., Nag P., Buhrlage S., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3Hartland, CL, Youngsaye W., Dockendorff C., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
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ML238: An Antimalarial Small Molecule of a Unique Structural ClassWeiwer, M., Mulrooney C., Massi D., Heidebrecht R., Wiegand R., Lukens AK, Dick J., Wirth D., Ekland E., Cheng CC, Zhao J., Yuan J., Su XZ, Johnson RL, Guha R., Dandapani S., Munoz B., Palmer M., Thomas C., Austin CP, et al., 2010/01/01, (2010) Read More / View Supplemental Materials
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Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2Bittker, JA, Weiwer M., Lewis T., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
  • Showing 1-30 of 30 Results