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2008
Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): Overview.Liu, CL, Bernstein BE, and Schreiber SL CSH protocols, 2008/05/01, Volume 2008, p.pdb.top42, (2008) Read More / View Supplemental Materials
Abstract
Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening.Wagner, BK, Carrinski HA, Ahn YH, Kim YK, Gilbert TJ, Fomina DA, Schreiber SL, Chang YT, and Clemons PA Journal of the American Chemical Society, 2008/04/02, Volume 130, Issue 13, p.4208-9, (2008) Read More / View Supplemental Materials
Abstract
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.Christofk, HR, Vander Heiden MG, Harris MH, Ramanathan A., Gerszten RE, Wei R., Fleming MD, Schreiber SL, and Cantley LC Nature, 2008/03/13, Volume 452, Issue 7184, p.230-3, (2008) Read More / View Supplemental Materials
Abstract
Large-scale chemical dissection of mitochondrial function.Wagner, BK, Kitami T., Gilbert TJ, Peck D., Ramanathan A., Schreiber SL, Golub T. R., and Mootha VK Nature biotechnology, 2008/03/01, Volume 26, Issue 3, p.343-51, (2008) Read More / View Supplemental Materials
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Small-molecule reagents for cellular pull-down experiments.Wang, X., Imber BS, and Schreiber SL Bioconjugate chemistry, 2008/03/01, Volume 19, Issue 3, p.585-7, (2008) Read More / View Supplemental Materials
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ChemBank: a small-molecule screening and cheminformatics resource database.Seiler, KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S., Brudz S., Sullivan JP, Muhlich J., Serrano M., Ferraiolo P., Tolliday NJ, Schreiber SL, and Clemons PA Nucleic acids research, 2008/01/01, Volume 36, Issue Database issue, p.D351-9, (2008) Read More / View Supplemental Materials
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Towards the optimal screening collection: a synthesis strategy.Nielsen, TE, and Schreiber SL Angewandte Chemie (International ed. in English), 2007/12/13, Volume 47, Issue 1, p.48-56, (2008) Read More / View Supplemental Materials
Abstract
2007
Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.Peng, LF, Kim SS, Matchacheep S., Lei X., Su S., Lin W., Runguphan W., Choe WH, Sakamoto N., Ikeda M., Kato N., Beeler AB, Porco JA Jr, Schreiber SL, and Chung RT Antimicrobial agents and chemotherapy, 2007/10/01, Volume 51, Issue 10, p.3756-9, (2007) Read More / View Supplemental Materials
Abstract
Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.Vegas, AJ, Bradner JE, Tang W., McPherson OM, Greenberg EF, Koehler AN, and Schreiber SL Angewandte Chemie (International ed. in English), 2007/09/17, Volume 46, Issue 42, p.7960-4, (2007) Read More / View Supplemental Materials
Evolutionarily conserved optimization of amino acid biosynthesis.Perlstein, EO, de Bivort BL, Kunes S., and Schreiber SL Journal of molecular evolution, 2007/08/01, Volume 65, Issue 2, p.186-96, (2007) Read More / View Supplemental Materials
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Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4.Evensen, E., Joseph-McCarthy D., Weiss GA, Schreiber SL, and Karplus M. Journal of computer-aided molecular design, 2007/07/01, Volume 21, Issue 7, p.395-418, (2007) Read More / View Supplemental Materials
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Rethinking relationships between natural products.Schreiber, SL Nature chemical biology, 2007/07/01, Volume 3, Issue 7, p.352, (2007) Read More / View Supplemental Materials
Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations.Perlstein, EO, Deeds EJ, Ashenberg O., Shakhnovich EI, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2007/06/19, Volume 104, Issue 25, p.10553-8, (2007) Read More / View Supplemental Materials
Abstract
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.Sarkar, S., Perlstein EO, Imarisio S., Pineau S., Cordenier A., Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, and Rubinsztein DC Nature chemical biology, 2007/06/01, Volume 3, Issue 6, p.331-8, (2007) Read More / View Supplemental Materials
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Genetic basis of individual differences in the response to small-molecule drugs in yeast.Perlstein, EO, Ruderfer DM, Roberts DC, Schreiber SL, and Kruglyak L. Nature genetics, 2007/04/01, Volume 39, Issue 4, p.496-502, (2007) Read More / View Supplemental Materials
Abstract
Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening.Yang, J., Shamji A., Matchacheep S., and Schreiber SL Chemistry & biology, 2007/04/01, Volume 14, Issue 4, p.371-7, (2007) Read More / View Supplemental Materials
Abstract
Synthesis and cellular profiling of diverse organosilicon small molecules.Franz, AK, Dreyfuss PD, and Schreiber SL Journal of the American Chemical Society, 2007/02/07, Volume 129, Issue 5, p.1020-1, (2007) Read More / View Supplemental Materials
A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication.Kim, SS, Peng LF, Lin W., Choe WH, Sakamoto N., Kato N., Ikeda M., Schreiber SL, and Chung RT Gastroenterology, 2007/01/01, Volume 132, Issue 1, p.311-20, (2007) Read More / View Supplemental Materials
Abstract
Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.Miao, H., Tallarico JA, Hayakawa H., Münger K., Duffner JL, Koehler AN, Schreiber SL, and Lewis TA Journal of combinatorial chemistry, 1969/12/31, Volume 9, Issue 2, p.245-53, (2007) Read More / View Supplemental Materials
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2006
An oligomer-based approach to skeletal diversity in small-molecule synthesis.Spiegel, DA, Schroeder FC, Duvall JR, and Schreiber SL Journal of the American Chemical Society, 2006/11/22, Volume 128, Issue 46, p.14766-7, (2006) Read More / View Supplemental Materials
Abstract
Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics.Tolliday, N., Clemons PA, Ferraiolo P., Koehler AN, Lewis TA, Li X., Schreiber SL, Gerhard DS, and Eliasof S. Cancer research, 2006/09/15, Volume 66, Issue 18, p.8935-42, (2006) Read More / View Supplemental Materials
Abstract
Query Chem: a Google-powered web search combining text and chemical structures.Klekota, J., Roth FP, and Schreiber SL Bioinformatics (Oxford, England), 2006/07/01, Volume 22, Issue 13, p.1670-3, (2006) Read More / View Supplemental Materials
Abstract
Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions.Kumagai, N., Muncipinto G., and Schreiber SL Angewandte Chemie (International ed. in English), 2006/05/26, Volume 45, Issue 22, p.3635-8, (2006) Read More / View Supplemental Materials
Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects.Klekota, J., Brauner E., Roth FP, and Schreiber SL Journal of chemical information and modeling, 2006/05/18, Volume 46, Issue 4, p.1549-62, (2006) Read More / View Supplemental Materials
Abstract
Macrocycloadditions leading to conformationally restricted small molecules.Looper, RE, Pizzirani D., and Schreiber SL Organic letters, 2006/05/11, Volume 8, Issue 10, p.2063-6, (2006) Read More / View Supplemental Materials
Abstract
A robust small-molecule microarray platform for screening cell lysates.Bradner, JE, McPherson OM, Mazitschek R., Barnes-Seeman D., Shen JP, Dhaliwal J., Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P., Schreiber SL, and Koehler AN Chemistry & biology, 2006/05/01, Volume 13, Issue 5, p.493-504, (2006) Read More / View Supplemental Materials
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells.Bernstein, BE, Mikkelsen TS, Xie X., Kamal M., Huebert DJ, Cuff J., Fry B., Meissner A., Wernig M., Plath K., Jaenisch R., Wagschal A., Feil R., Schreiber SL, and Lander E. S. Cell, 2006/04/21, Volume 125, Issue 2, p.315-26, (2006) Read More / View Supplemental Materials
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Revealing complex traits with small molecules and naturally recombinant yeast strains.Perlstein, EO, Ruderfer DM, Ramachandran G., Haggarty SJ, Kruglyak L., and Schreiber SL Chemistry & biology, 2006/03/01, Volume 13, Issue 3, p.319-27, (2006) Read More / View Supplemental Materials
Abstract
Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.Butcher, RA, Bhullar BS, Perlstein EO, Marsischky G., LaBaer J., and Schreiber SL Nature chemical biology, 2006/02/01, Volume 2, Issue 2, p.103-9, (2006) Read More / View Supplemental Materials
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Enantioselective addition of terminal alkynes to isolated isoquinoline iminiums.Taylor, AM, and Schreiber SL Organic letters, 2006/01/05, Volume 8, Issue 1, p.143-6, (2006) Read More / View Supplemental Materials
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2005
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.Raisner, RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, and Madhani HD Cell, 2005/10/21, Volume 123, Issue 2, p.233-48, (2005) Read More / View Supplemental Materials
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SpectralNET--an application for spectral graph analysis and visualization.Forman, JJ, Clemons PA, Schreiber SL, and Haggarty SJ BMC bioinformatics, 2005/10/19, Volume 6, p.260, (2005) Read More / View Supplemental Materials
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Single-nucleosome mapping of histone modifications in S. cerevisiae.Liu, CL, Kaplan T., Kim M., Buratowski S., Schreiber SL, Friedman N., and Rando OJ PLoS biology, 2005/10/01, Volume 3, Issue 10, p.e328, (2005) Read More / View Supplemental Materials
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From solution-phase to solid-phase enyne metathesis: crossover in the relative performance of two commonly used ruthenium pre-catalysts.Brittain, DE, Gray BL, and Schreiber SL Chemistry (Weinheim an der Bergstrasse, Germany), 2005/08/19, Volume 11, Issue 17, p.5086-93, (2005) Read More / View Supplemental Materials
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Small molecules: the missing link in the central dogma.Schreiber, SL Nature chemical biology, 2005/07/01, Volume 1, Issue 2, p.64-6, (2005) Read More / View Supplemental Materials
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Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.Saji, S., Kawakami M., Hayashi S., Yoshida N., Hirose M., Horiguchi S., Itoh A., Funata N., Schreiber SL, Yoshida M., and Toi M. Oncogene, 2005/06/30, Volume 24, Issue 28, p.4531-9, (2005) Read More / View Supplemental Materials
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Small-molecule diversity using a skeletal transformation strategy.Kumar, N., Kiuchi M., Tallarico JA, and Schreiber SL Organic letters, 2005/06/23, Volume 7, Issue 13, p.2535-8, (2005) Read More / View Supplemental Materials
Abstract
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.Hideshima, T., Bradner JE, Wong J., Chauhan D., Richardson P., Schreiber SL, and Anderson KC Proceedings of the National Academy of Sciences of the United States of America, 2005/06/14, Volume 102, Issue 24, p.8567-72, (2005) Read More / View Supplemental Materials
Abstract
Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.Van Stry, M., Kazlauskas A., Schreiber SL, and Symes K. Proceedings of the National Academy of Sciences of the United States of America, 2005/06/07, Volume 102, Issue 23, p.8233-8, (2005) Read More / View Supplemental Materials
Abstract
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements.Ramanathan, A., Wang C., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2005/04/26, Volume 102, Issue 17, p.5992-7, (2005) Read More / View Supplemental Materials
Abstract
Convergent diversity-oriented synthesis of small-molecule hybrids.Chen, C., Li X., Neumann CS, Lo MM, and Schreiber SL Angewandte Chemie (International ed. in English), 2005/04/08, Volume 44, Issue 15, p.2249-52, (2005) Read More / View Supplemental Materials
Using genome-wide transcriptional profiling to elucidate small-molecule mechanism.Butcher, RA, and Schreiber SL Current opinion in chemical biology, 2005/02/01, Volume 9, Issue 1, p.25-30, (2005) Read More / View Supplemental Materials
Abstract
Genomic maps and comparative analysis of histone modifications in human and mouse.Bernstein, BE, Kamal M., Lindblad-Toh K., Bekiranov S., Bailey DK, Huebert DJ, McMahon S., Karlsson EK, Kulbokas EJ 3rd, Gingeras TR, Schreiber SL, and Lander E. S. Cell, 2005/01/28, Volume 120, Issue 2, p.169-81, (2005) Read More / View Supplemental Materials
Abstract
Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons.Oguri, H., and Schreiber SL Organic letters, 2005/01/06, Volume 7, Issue 1, p.47-50, (2005) Read More / View Supplemental Materials
Abstract
Identifying biologically active compound classes using phenotypic screening data and sampling statistics.Klekota, J., Brauner E., and Schreiber SL Journal of chemical information and modeling, 1969/12/31, Volume 45, Issue 6, p.1824-36, (2005) Read More / View Supplemental Materials
Abstract
2004
A library of spirooxindoles based on a stereoselective three-component coupling reaction.Lo, MM, Neumann CS, Nagayama S., Perlstein EO, and Schreiber SL Journal of the American Chemical Society, 2004/12/15, Volume 126, Issue 49, p.16077-86, (2004) Read More / View Supplemental Materials
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Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.Huang, J., Zhu H., Haggarty SJ, Spring DR, Hwang H., Jin F., Snyder M., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2004/11/23, Volume 101, Issue 47, p.16594-9, (2004) Read More / View Supplemental Materials
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Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space.Kim, YK, Arai MA, Arai T., Lamenzo JO, Dean EF 3rd, Patterson N., Clemons PA, and Schreiber SL Journal of the American Chemical Society, 2004/11/17, Volume 126, Issue 45, p.14740-5, (2004) Read More / View Supplemental Materials
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Stereochemical control of the Passerini reaction.Andreana, PR, Liu CC, and Schreiber SL Organic letters, 2004/11/11, Volume 6, Issue 23, p.4231-3, (2004) Read More / View Supplemental Materials
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A synthesis strategy yielding skeletally diverse small molecules combinatorially.Burke, MD, Berger EM, and Schreiber SL Journal of the American Chemical Society, 2004/11/03, Volume 126, Issue 43, p.14095-104, (2004) Read More / View Supplemental Materials
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Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors.Haggarty, SJ, Clemons PA, Wong JC, and Schreiber SL Combinatorial chemistry & high throughput screening, 2004/11/01, Volume 7, Issue 7, p.669-76, (2004) Read More / View Supplemental Materials
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Syntheses of stereochemically diverse nine-membered ring-containing biaryls.Krishnan, S., and Schreiber SL Organic letters, 2004/10/28, Volume 6, Issue 22, p.4021-4, (2004) Read More / View Supplemental Materials
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Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes.Wong, JC, Sternson SM, Louca JB, Hong R., and Schreiber SL Chemistry & biology, 2004/09/01, Volume 11, Issue 9, p.1279-91, (2004) Read More / View Supplemental Materials
Abstract
Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection.Butcher, RA, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2004/05/25, Volume 101, Issue 21, p.7868-73, (2004) Read More / View Supplemental Materials
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Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.Peterson, RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, Schreiber SL, Macrae CA, and Fishman MC Nature biotechnology, 2004/05/01, Volume 22, Issue 5, p.595-9, (2004) Read More / View Supplemental Materials
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Stuart Schreiber: biology from a chemist's perspective. Interview by Joanna Owens.Schreiber, SL Drug discovery today, 2004/04/01, Volume 9, Issue 7, p.299-303, (2004) Read More / View Supplemental Materials
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Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates.Taylor, SJ, Taylor AM, and Schreiber SL Angewandte Chemie (International ed. in English), 2004/03/19, Volume 43, Issue 13, p.1681-5, (2004) Read More / View Supplemental Materials
Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.Humphrey, EL, Shamji AF, Bernstein BE, and Schreiber SL Chemistry & biology, 2004/03/01, Volume 11, Issue 3, p.295-9, (2004) Read More / View Supplemental Materials
Abstract
Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization.Schmidt, DR, Kwon O., and Schreiber SL Journal of combinatorial chemistry, 2004/01/20, Volume 6, Issue 2, p.286-92, (2004) Read More / View Supplemental Materials
2003
Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.Koehler, AN, Shamji AF, and Schreiber SL Journal of the American Chemical Society, 2003/07/16, Volume 125, Issue 28, p.8420-1, (2003) Read More / View Supplemental Materials
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Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands.Barnes-Seeman, D., Park SB, Koehler AN, and Schreiber SL Angewandte Chemie (International ed. in English), 2003/05/30, Volume 42, Issue 21, p.2376-9, (2003) Read More / View Supplemental Materials
2001
A one-bead, one-stock solution approach to chemical genetics: part 2.Clemons, PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, and Foley MA Chemistry & biology, 2001/12/01, Volume 8, Issue 12, p.1183-95, (2001) Read More / View Supplemental Materials
Abstract
1969
Skeletal diversity in small-molecule synthesis using ligand-controlled catalysis.Gray, BL, and Schreiber SL Journal of combinatorial chemistry, 1969/12/31, Volume 9, Issue 6, p.1028-35, (1969) Read More / View Supplemental Materials
Abstract
Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.Floto, RA, Sarkar S., Perlstein EO, Kampmann B., Schreiber SL, and Rubinsztein DC Autophagy, 1969/12/31, Volume 3, Issue 6, p.620-2, (1969) Read More / View Supplemental Materials
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