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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2014
Diversity-Oriented Synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.Lukens, AK, Heidebrecht RW Jr, Mulrooney C., Beaudoin JA, Comer E., Duvall JR, Fitzgerald ME, Masi D., Galinsky K., Scherer CA, Palmer M., Munoz B., Foley M., Schreiber SL, Wiegand RC, and Wirth DF The Journal of infectious diseases, 2014/10/21, (2014) Read More / View Supplemental Materials
Abstract
Small-molecule control of cytokine function: new opportunities for treating immune disorders.Sundberg, TB, Xavier RJ, Schreiber SL, and Shamji AF Current opinion in chemical biology, 2014/09/12, Volume 23C, p.23-30, (2014) Read More / View Supplemental Materials
Abstract
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.Sundberg, TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B., Gagnon J., O'Connell DJ, Narayan K., Dančík V., Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, and Shamji AF Proceedings of the National Academy of Sciences of the United States of America, 2014/08/11, (2014) Read More / View Supplemental Materials
Abstract
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.Wawer, MJ, Li K., Gustafsdottir SM, Ljosa V., Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E., Taylor B., Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V., Narayan R., Subramanian A., Winckler W., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine.Wurst, JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L., Perez JR, Dandapani S., Palmer M., Moskowitz SM, Schreiber SL, Munoz B., and Gulick AM ACS chemical biology, 2014/05/21, (2014) Read More / View Supplemental Materials
Abstract
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.Lassen, KG, Kuballa P., Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L., Horn H., Mercer J., Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly M. J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/05/12, (2014) Read More / View Supplemental Materials
Abstract
Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Wawer, MJ, Jaramillo DE, Dančik V., Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, and Clemons PA Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
Abstract
Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.Dandapani, S., Germain AR, Jewett I., le Quement S., Marie JC, Muncipinto G., Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J., Kellar D., Siqueira-Neto JL, McKerrow JH, Kaiser M., Rodriguez A., Palmer MA, Foley M., Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2014/02/13, Volume 5, Issue 2, p.149-53, (2014) Read More / View Supplemental Materials
Abstract
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.Krönke, J., Udeshi ND, Narla A., Grauman P., Hurst SN, McConkey M., Svinkina T., Heckl D., Comer E., Li X., Ciarlo C., Hartman E., Munshi N., Schenone M., Schreiber SL, Carr SA, and Ebert BL Science (New York, N.Y.), 2014/01/17, Volume 343, Issue 6168, p.301-5, (2014) Read More / View Supplemental Materials
Abstract
Regulation of Ferroptotic Cancer Cell Death by GPX4.Yang, WS, Sriramaratnam R., Welsch ME, Shimada K., Skouta R., Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, and Stockwell BR Cell, 2014/01/16, Volume 156, Issue 1-2, p.317-31, (2014) Read More / View Supplemental Materials
Abstract
Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming.Choudhary, A., Hu He K., Mertins P., Udeshi ND, Dančík V., Fomina-Yadlin D., Kubicek S., Clemons PA, Schreiber SL, Carr SA, and Wagner BK PloS one, 2014/01/01, Volume 9, Issue 4, p.e95194, (2014) Read More / View Supplemental Materials
Abstract
2013
Multiplex cytological profiling assay to measure diverse cellular States.Gustafsdottir, SM, Ljosa V., Sokolnicki KL, Anthony Wilson J., Walpita D., Kemp MM, Petri Seiler K., Carrel HA, Golub T. R., Schreiber SL, Clemons PA, Carpenter AE, and Shamji AF PloS one, 2013/12/02, Volume 8, Issue 12, p.e80999, (2013) Read More / View Supplemental Materials
Abstract
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Hartwell, KA, Miller PG, Mukherjee S., Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M., Järås M., Puram R., Dancik V., Al-Shahrour F., Kindler T., Tothova Z., Chattopadhyay S., Hasaka T., Narayan R., Dai M., Huang C., Shterental S., et al. Nature chemical biology, 2013/12/01, Volume 9, Issue 12, p.840-8, (2013) Read More / View Supplemental Materials
Abstract
A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening.Yuan, Y., Hartland K., Boskovic Z., Wang Y., Walpita D., Lysy PA, Zhong C., Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, and Wagner BK Chemistry & biology, 2013/11/23, (2013) Read More / View Supplemental Materials
Abstract
Integrative radiogenomic profiling of squamous cell lung cancer.Abazeed, ME, Adams DJ, Hurov KE, Tamayo P., Creighton CJ, Sonkin D., Giacomelli AO, Du C., Fries DF, Wong KK, Mesirov J. P., Loeffler JS, Schreiber SL, Hammerman PS, and Meyerson M. Cancer research, 2013/10/15, Volume 73, Issue 20, p.6289-98, (2013) Read More / View Supplemental Materials
Abstract
Synthesis of piperlogs and analysis of their effects on cells.Boskovic, ZV, Hussain MM, Adams DJ, Dai M., and Schreiber SL Tetrahedron, 2013/09/09, Volume 69, Issue 36, (2013) Read More / View Supplemental Materials
Abstract
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.Basu, A., Bodycombe NE, Cheah JH, Price EV, Liu K., Schaefer GI, Ebright RY, Stewart ML, Ito D., Wang S., Bracha AL, Liefeld T., Wawer M., Gilbert JC, Wilson AJ, Stransky N., Kryukov GV, Dancik V., Barretina J., Garraway LA, et al. Cell, 2013/08/29, Volume 154, Issue 5, p.1151-61, (2013) Read More / View Supplemental Materials
Abstract
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.Conway, KL, Kuballa P., Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M., Aldrich LN, Villablanca EJ, Peloquin JM, Goel G., Lee IA, Mizoguchi E., Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, et al. Gastroenterology, 2013/08/21, (2013) Read More / View Supplemental Materials
Abstract
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.Yuan, Y., Tang AJ, Castoreno AB, Kuo SY, Wang Q., Kuballa P., Xavier R., Shamji AF, Schreiber SL, and Wagner BK Cell death & disease, 2013/06/27, Volume 4, p.e690, (2013) Read More / View Supplemental Materials
Abstract
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.Adams, DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, and Schreiber SL ACS chemical biology, 2013/03/25, (2013) Read More / View Supplemental Materials
Abstract
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.Germain, AR, Carmody LC, Nag PP, Morgan B., VerPlank L., Fernandez C., Donckele E., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2013/03/15, Volume 23, Issue 6, p.1834-8, (2013) Read More / View Supplemental Materials
Abstract
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.Youngsaye, W., Hartland CL, Morgan BJ, Ting A., Nag PP, Vincent B., Mosher CA, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Beilstein journal of organic chemistry, 2013/01/01, Volume 9, p.1501-7, (2013) Read More / View Supplemental Materials
Abstract
2012
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Weïwer, M., Spoonamore J., Wei J., Guichard B., Ross NT, Masson K., Silkworth W., Dandapani S., Palmer M., Scherer CA, Stern AM, Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2012/12/13, Volume 3, Issue 12, p.1034-1038, (2012) Read More / View Supplemental Materials
Abstract
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Dockendorff, C., Nagiec MM, Weïwer M., Buhrlage S., Ting A., Nag PP, Germain A., Kim HJ, Youngsaye W., Scherer C., Bennion M., Xue L., Stanton BZ, Lewis TA, Macpherson L., Palmer M., Foley MA, Perez JR, and Schreiber SL ACS medicinal chemistry letters, 2012/10/11, Volume 3, Issue 10, p.808-813, (2012) Read More / View Supplemental Materials
Abstract
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials
Abstract
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Q., Goldenson B., Silver SJ, Schenone M., Dancik V., Huang Z., Wang LZ, Lewis TA, An WF, Li X., Bray MA, Thiollier C., Diebold L., Gilles L., Vokes MS, Moore CB, Bliss-Moreau M., VerPlank L., Tolliday NJ, Mishra R., et al. Cell, 2012/08/03, Volume 150, Issue 3, p.575-89, (2012) Read More / View Supplemental Materials
Abstract
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Fass, DM, Reis SA, Ghosh B., Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W., Barker DD, Mazitschek R., Schreiber SL, Tsai LH, and Haggarty SJ Neuropharmacology, 2012/07/04, (2012) Read More / View Supplemental Materials
Abstract
Inhibition of histone deacetylase 3 protects Beta cells from cytokine-induced apoptosis.Chou, DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, and Wagner BK Chemistry & biology, 2012/06/22, Volume 19, Issue 6, p.669-73, (2012) Read More / View Supplemental Materials
Abstract
Identification of a selective small molecule inhibitor of breast cancer stem cells.Germain, AR, Carmody LC, Morgan B., Fernandez C., Forbeck E., Lewis TA, Nag PP, Ting A., VerPlank L., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/15, Volume 22, Issue 10, p.3571-4, (2012) Read More / View Supplemental Materials
Abstract
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.Youngsaye, W., Dockendorff C., Vincent B., Hartland CL, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/01, Volume 22, Issue 9, p.3362-5, (2012) Read More / View Supplemental Materials
Abstract
A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma.Yuan, Y., Wang Q., Paulk J., Kubicek S., Kemp MM, Adams DJ, Shamji AF, Wagner BK, and Schreiber SL ACS chemical biology, 2012/04/30, (2012) Read More / View Supplemental Materials
Abstract
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.Kubicek, S., Gilbert JC, Fomina-Yadlin D., Gitlin AD, Yuan Y., Wagner FF, Holson EB, Luo T., Lewis TA, Taylor B., Gupta S., Shamji AF, Wagner BK, Clemons PA, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/04/03, Volume 109, Issue 14, p.5364-9, (2012) Read More / View Supplemental Materials
Abstract
Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.Dockendorff, C., Aisiku O., VerPlank L., Dilks JR, Smith DA, Gunnink SF, Dowal L., Negri J., Palmer M., Macpherson L., Schreiber SL, and Flaumenhaft R. ACS medicinal chemistry letters, 2012/03/08, Volume 3, Issue 3, p.232-237, (2012) Read More / View Supplemental Materials
Abstract
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.Luo, T., Masson K., Jaffe JD, Silkworth W., Ross NT, Scherer CA, Scholl C., Fröhling S., Carr SA, Stern AM, Schreiber SL, and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2012/02/21, Volume 109, Issue 8, p.2860-5, (2012) Read More / View Supplemental Materials
Abstract
Development of small-molecule probes that selectively kill cells induced to express mutant RAS.Weïwer, M., Bittker JA, Lewis TA, Shimada K., Yang WS, Macpherson L., Dandapani S., Palmer M., Stockwell BR, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/02/15, Volume 22, Issue 4, p.1822-6, (2012) Read More / View Supplemental Materials
Abstract
Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of a small molecule that selectively activates alpha-synuclein translational expressionRoss, NT, Metkar SR, Le H., Burbank J., Cahill C., Germain A., Macpherson L., Bittker J., Palmer M., Rogers J., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of a small molecule that selectively inhibits alpha-synuclein translational expressionRoss, NT, Metkar SR, Le H., Burbank J., Cahill C., Germain A., Macpherson L., Bittker J., Palmer M., Rogers J., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet CellsFaloon, PW, Chou DHC, Forbeck EM, Walpita D., Morgan B., Buhrlage S., Ting A., Perez J., MacPherson LJ, Duvall JR, Dandapani S., Marcaurelle LA, Munoz B., Palmer M., Foley M., Wagner B., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1An, WF, Metkar SR, Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2An, WF, Metkar SR, Lewis TA, Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3An, WF, Metkar SR, Youngsaye W., Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small-Molecule Inhibitors of Trypansoma cruzi InfectionCarmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1Carmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3Carmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC.Ong, SE, Li X., Schenone M., Schreiber SL, and Carr SA Methods in molecular biology (Clifton, N.J.), 2012/01/09, Volume 803, p.129-40, (2012) Read More / View Supplemental Materials
Abstract
Complex alpha-pyrones synthesized by a gold-catalyzed coupling reaction.Luo, T., and Schreiber SL Angewandte Chemie (International ed. in English), 2012/01/06, Volume 46, Issue 43, p.8250-3, (2012) Read More / View Supplemental Materials
A microarray-based protocol for monitoring the growth of yeast overexpression strains.Butcher, RA, and Schreiber SL Nature protocols, 2012/01/06, Volume 1, Issue 2, p.569-76, (2012) Read More / View Supplemental Materials
Abstract
Multilevel regulation of growth rate in yeast revealed using systems biology.Ramanathan, A., and Schreiber SL Journal of biology, 2012/01/06, Volume 6, Issue 2, p.3, (2012) Read More / View Supplemental Materials
Abstract
Correction: GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity.Fomina-Yadlin, D., Kubicek S., Vetere A., Hu He KH, Schreiber SL, and Wagner BK PloS one, 2012/01/01, Volume 7, Issue 3, (2012) Read More / View Supplemental Materials
Abstract
GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.Fomina-Yadlin, D., Kubicek S., Vetere A., He KH, Schreiber SL, and Wagner BK PloS one, 2012/01/01, Volume 7, Issue 1, p.e28808, (2012) Read More / View Supplemental Materials
Abstract
2011
Global nucleosome occupancy in yeast.Bernstein, BE, Liu CL, Humphrey EL, Perlstein EO, and Schreiber SL Genome biology, 2011/12/08, Volume 5, Issue 9, p.R62, (2011) Read More / View Supplemental Materials
Abstract
The use of chromatin immunoprecipitation assays in genome-wide analyses of histone modifications.Bernstein, BE, Humphrey EL, Liu CL, and Schreiber SL Methods in enzymology, 2011/12/08, Volume 376, p.349-60, (2011) Read More / View Supplemental Materials
A Human Islet Cell Culture System for High-Throughput Screening.Walpita, D., Hasaka T., Spoonamore J., Vetere A., Takane KK, Fomina-Yadlin D., Fiaschi-Taesch N., Shamji A., Clemons PA, Stewart AF, Schreiber SL, and Wagner BK Journal of biomolecular screening, 2011/12/07, (2011) Read More / View Supplemental Materials
Abstract
Identification of small-molecule inhibitors of Trypansoma cruzi replication.Germain, AR, Carmody LC, Dockendorff C., Galan-Rodriguez C., Rodriguez A., Johnston S., Bittker JA, Macpherson L., Dandapani S., Palmer M., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2011/12/01, Volume 21, Issue 23, p.7197-200, (2011) Read More / View Supplemental Materials
Abstract
Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.Zhong, C., Wang Y., Hung AW, Schreiber SL, and Young DW Organic letters, 2011/10/21, Volume 13, Issue 20, p.5556-9, (2011) Read More / View Supplemental Materials
Abstract
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.Wilson, AJ, Holson E., Wagner F., Zhang YL, Fass DM, Haggarty SJ, Bhaskara S., Hiebert SW, Schreiber SL, and Khabele D. Cancer biology & therapy, 2011/09/15, Volume 12, Issue 6, p.484-93, (2011) Read More / View Supplemental Materials
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Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.Youngsaye, W., Vincent B., Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S., Bittker JA, Macpherson L., Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2011/09/15, Volume 21, Issue 18, p.5502-5, (2011) Read More / View Supplemental Materials
Abstract
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.Peng, LF, Schaefer EA, Maloof N., Skaff A., Berical A., Belon CA, Heck JA, Lin W., Frick DN, Allen TM, Miziorko HM, Schreiber SL, and Chung RT The Journal of infectious diseases, 2011/08/15, Volume 204, Issue 4, p.609-16, (2011) Read More / View Supplemental Materials
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AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Kuai, L., Ong SE, Madison JM, Wang X., Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, and Haggarty SJ Chemistry & biology, 2011/07/29, Volume 18, Issue 7, p.891-906, (2011) Read More / View Supplemental Materials
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A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials
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Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials
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Catalytic Diastereoselective Petasis Reactions.Muncipinto, G., Moquist PN, Schreiber SL, and Schaus SE Angewandte Chemie (International ed. in English), 2011/07/12, (2011) Read More / View Supplemental Materials
Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Wang, Y., Jimenez M., Hansen AS, Raiber EA, Schreiber SL, and Young DW Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9196-9, (2011) Read More / View Supplemental Materials
Abstract
A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X., Liu Y., Kubicek S., Myllyharju J., Tumber A., Ng S., Che KH, Podoll J., Heightman TD, Oppermann U., Schreiber SL, and Wang X. Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9451-6, (2011) Read More / View Supplemental Materials
Abstract
Syntheses of α-pyrones using gold-catalyzed coupling reactions.Luo, T., Dai M., Zheng SL, and Schreiber SL Organic letters, 2011/06/03, Volume 13, Issue 11, p.2834-6, (2011) Read More / View Supplemental Materials
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Discovery of histone deacetylase 8 selective inhibitors.Tang, W., Luo T., Greenberg EF, Bradner JE, and Schreiber SL Bioorganic & medicinal chemistry letters, 2011/05/01, Volume 21, Issue 9, p.2601-5, (2011) Read More / View Supplemental Materials
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Organic synthesis toward small-molecule probes and drugs.Schreiber, SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6699-702, (2011) Read More / View Supplemental Materials
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Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Clemons, PA, Wilson JA, Dančík V., Muller S., Carrinski HA, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6817-22, (2011) Read More / View Supplemental Materials
Abstract
Chemoproteomics quantifies complexity.Holson, EB, and Schreiber SL Nature biotechnology, 2011/03/01, Volume 29, Issue 3, p.235-6, (2011) Read More / View Supplemental Materials
Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.Shaw, SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/01/11, Volume 108, Issue 2, p.492-7, (2011) Read More / View Supplemental Materials
Abstract
2010
Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.Muncipinto, G., Kaya T., Wilson JA, Kumagai N., Clemons PA, and Schreiber SL Organic letters, 2010/11/19, Volume 12, Issue 22, p.5230-3, (2010) Read More / View Supplemental Materials
Abstract
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/11/02, Volume 107, Issue 44, p.18787-92, (2010) Read More / View Supplemental Materials
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Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres.O'Sullivan, RJ, Kubicek S., Schreiber SL, and Karlseder J. Nature structural & molecular biology, 2010/10/01, Volume 17, Issue 10, p.1218-25, (2010) Read More / View Supplemental Materials
Abstract
Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials
Small-molecule inducers of insulin expression in pancreatic alpha-cells.Fomina-Yadlin, D., Kubicek S., Walpita D., Dancik V., Hecksher-Sørensen J., Bittker JA, Sharifnia T., Shamji A., Clemons PA, Wagner BK, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/08/24, Volume 107, Issue 34, p.15099-104, (2010) Read More / View Supplemental Materials
Abstract
Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.Chou, DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, and Wagner BK ACS chemical biology, 2010/08/20, Volume 5, Issue 8, p.729-34, (2010) Read More / View Supplemental Materials
Abstract
Distinct biological network properties between the targets of natural products and disease genes.Dancík, V., Seiler KP, Young DW, Schreiber SL, and Clemons PA Journal of the American Chemical Society, 2010/07/14, Volume 132, Issue 27, p.9259-61, (2010) Read More / View Supplemental Materials
Abstract
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials
Abstract
Stereochemical and skeletal diversity arising from amino propargylic alcohols.Pizzirani, D., Kaya T., Clemons PA, and Schreiber SL Organic letters, 2010/06/18, Volume 12, Issue 12, p.2822-5, (2010) Read More / View Supplemental Materials
Abstract
Screen for RAS-Selective Lethal Compounds and VDAC LigandsBittker, JA, Weiwer M., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/03/26, (2010) Read More / View Supplemental Materials
Abstract
Carbon metabolism-mediated myogenic differentiation.Bracha, AL, Ramanathan A., Huang S., Ingber DE, and Schreiber SL Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.202-204, (2010) Read More / View Supplemental Materials
Abstract
Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast.Radman-Livaja, M., Liu CL, Friedman N., Schreiber SL, and Rando OJ PLoS genetics, 2010/02/05, Volume 6, Issue 2, p.e1000837, (2010) Read More / View Supplemental Materials
Abstract
Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.Kuai, L., Wang X., Madison JM, Schreiber SL, Scolnick EM, and Haggarty SJ ACS chemical neuroscience, 2010/01/28, Volume 1, Issue 4, p.325-342, (2010) Read More / View Supplemental Materials
Abstract
Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.Tassa, C., Duffner JL, Lewis TA, Weissleder R., Schreiber SL, Koehler AN, and Shaw SY Bioconjugate chemistry, 2010/01/01, Volume 21, Issue 1, p.14-9, (2010) Read More / View Supplemental Materials
Abstract
Discovery of Inhibitors of Anti-Apoptotic Protein A1Bittker, JA, Weiwer M., Wei G., Germain A., Brown E., Dandapani S., Munoz B., Palmer M., Golub T., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2Hartland, CL, Youngsaye W., Morgan B., Ting A., Nag P., Buhrlage S., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3Hartland, CL, Youngsaye W., Dockendorff C., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
ML238: An Antimalarial Small Molecule of a Unique Structural ClassWeiwer, M., Mulrooney C., Massi D., Heidebrecht R., Wiegand R., Lukens AK, Dick J., Wirth D., Ekland E., Cheng CC, Zhao J., Yuan J., Su XZ, Johnson RL, Guha R., Dandapani S., Munoz B., Palmer M., Thomas C., Austin CP, et al., 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2Bittker, JA, Weiwer M., Lewis T., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
2009
Direct control of mitochondrial function by mTOR.Ramanathan, A., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2009/12/29, Volume 106, Issue 52, p.22229-32, (2009) Read More / View Supplemental Materials
Abstract
Copper-mediated amidation of heterocyclic and aromatic C-H bonds.Wang, Q., and Schreiber SL Organic letters, 2009/11/19, Volume 11, Issue 22, p.5178-80, (2009) Read More / View Supplemental Materials
Abstract
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.Peng, LF, Stanton BZ, Maloof N., Wang X., and Schreiber SL Bioorganic & medicinal chemistry letters, 2009/11/15, Volume 19, Issue 22, p.6319-25, (2009) Read More / View Supplemental Materials
Abstract
Empirical Bayes analysis of quantitative proteomics experiments.Margolin, AA, Ong SE, Schenone M., Gould R., Schreiber SL, Carr SA, and Golub T. R. PloS one, 2009/10/14, Volume 4, Issue 10, p.e7454, (2009) Read More / View Supplemental Materials
Abstract
Identification and characterization of novel sirtuin inhibitor scaffolds.Sanders, BD, Jackson B., Brent M., Taylor AM, Dang W., Berger SL, Schreiber SL, Howitz K., and Marmorstein R. Bioorganic & medicinal chemistry, 2009/10/01, Volume 17, Issue 19, p.7031-41, (2009) Read More / View Supplemental Materials
Abstract
Using expression and genotype to predict drug response in yeast.Ruderfer, DM, Roberts DC, Schreiber SL, Perlstein EO, and Kruglyak L. PloS one, 2009/09/04, Volume 4, Issue 9, p.e6907, (2009) Read More / View Supplemental Materials
Abstract
SnapShot: Ca2+-calcineurin-NFAT signaling.Crabtree, GR, and Schreiber SL Cell, 2009/07/10, Volume 138, Issue 1, p.210, 210.e1, (2009) Read More / View Supplemental Materials
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