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2011
Unbiased binding assays for discovering small-molecule probes and drugs.Kemp, MM, Weïwer M., and Koehler AN Bioorganic & medicinal chemistry, 2011/12/24, (2011) Read More / View Supplemental Materials
Abstract
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials
Abstract
Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Clemons, PA, Wilson JA, Dančík V., Muller S., Carrinski HA, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6817-22, (2011) Read More / View Supplemental Materials
Abstract
Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.Kang, MS, Lee EK, Soni V., Lewis TA, Koehler AN, Srinivasan V., and Kieff E. Journal of virology, 2011/03/01, Volume 85, Issue 6, p.2859-68, (2011) Read More / View Supplemental Materials
Abstract
2010
Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.Chen, J., Armstrong AH, Koehler AN, and Hecht MH Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.17015-22, (2010) Read More / View Supplemental Materials
Abstract
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/11/02, Volume 107, Issue 44, p.18787-92, (2010) Read More / View Supplemental Materials
Abstract
Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials
A complex task? Direct modulation of transcription factors with small molecules.Koehler, AN Current opinion in chemical biology, 2010/06/01, Volume 14, Issue 3, p.331-40, (2010) Read More / View Supplemental Materials
Abstract
Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.Tassa, C., Duffner JL, Lewis TA, Weissleder R., Schreiber SL, Koehler AN, and Shaw SY Bioconjugate chemistry, 2010/01/01, Volume 21, Issue 1, p.14-9, (2010) Read More / View Supplemental Materials
Abstract
Detecting protein-small molecule interactions using fluorous small-molecule microarrays.Vegas, AJ, and Koehler AN Methods in molecular biology (Clifton, N.J.), 2010/01/01, Volume 669, p.43-55, (2010) Read More / View Supplemental Materials
Abstract
2009
Identifying the proteins to which small-molecule probes and drugs bind in cells.Ong, SE, Schenone M., Margolin AA, Li X., Do K., Doud MK, Mani D. R., Kuai L., Wang X., Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub T. R., Gould RJ, Schreiber SL, and Carr SA Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4617-22, (2009) Read More / View Supplemental Materials
Abstract
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.Mao, Y., Ge X., Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C., Berry EM, Soda T., Singh KK, Biechele T., Petryshen TL, Moon RT, Haggarty SJ, and Tsai LH Cell, 2009/03/20, Volume 136, Issue 6, p.1017-31, (2009) Read More / View Supplemental Materials
Abstract
A small molecule that binds Hedgehog and blocks its signaling in human cells.Stanton, BZ, Peng LF, Maloof N., Nakai K., Wang X., Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A., and Schreiber SL Nature chemical biology, 2009/03/01, Volume 5, Issue 3, p.154-6, (2009) Read More / View Supplemental Materials
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2008
Small-molecule microarrays as tools in ligand discovery.Vegas, AJ, Fuller JH, and Koehler AN Chemical Society reviews, 2008/07/01, Volume 37, Issue 7, p.1385-94, (2008) Read More / View Supplemental Materials
Abstract
Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.Nieland, TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S., Zannis VI, Kirchhausen T., and Krieger M. Biochemistry, 2008/01/08, Volume 47, Issue 1, p.460-72, (2008) Read More / View Supplemental Materials
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2007
Detecting binding interactions using microarrays of natural product extracts.Schmitz, K., Haggarty SJ, McPherson OM, Clardy J., and Koehler AN Journal of the American Chemical Society, 2007/09/19, Volume 129, Issue 37, p.11346-7, (2007) Read More / View Supplemental Materials
Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.Vegas, AJ, Bradner JE, Tang W., McPherson OM, Greenberg EF, Koehler AN, and Schreiber SL Angewandte Chemie (International ed. in English), 2007/09/17, Volume 46, Issue 42, p.7960-4, (2007) Read More / View Supplemental Materials
Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.Nieland, TJ, Shaw JT, Jaipuri FA, Maliga Z., Duffner JL, Koehler AN, and Krieger M. Journal of lipid research, 2007/08/01, Volume 48, Issue 8, p.1832-45, (2007) Read More / View Supplemental Materials
Abstract
A pipeline for ligand discovery using small-molecule microarrays.Duffner, JL, Clemons PA, and Koehler AN Current opinion in chemical biology, 2007/02/01, Volume 11, Issue 1, p.74-82, (2007) Read More / View Supplemental Materials
Abstract
Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.Miao, H., Tallarico JA, Hayakawa H., Münger K., Duffner JL, Koehler AN, Schreiber SL, and Lewis TA Journal of combinatorial chemistry, 1969/12/31, Volume 9, Issue 2, p.245-53, (2007) Read More / View Supplemental Materials
Abstract
2006
A method for the covalent capture and screening of diverse small molecules in a microarray format.Bradner, JE, McPherson OM, and Koehler AN Nature protocols, 2006/12/21, Volume 1, Issue 5, p.2344-52, (2006) Read More / View Supplemental Materials
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Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics.Tolliday, N., Clemons PA, Ferraiolo P., Koehler AN, Lewis TA, Li X., Schreiber SL, Gerhard DS, and Eliasof S. Cancer research, 2006/09/15, Volume 66, Issue 18, p.8935-42, (2006) Read More / View Supplemental Materials
Abstract
A robust small-molecule microarray platform for screening cell lysates.Bradner, JE, McPherson OM, Mazitschek R., Barnes-Seeman D., Shen JP, Dhaliwal J., Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P., Schreiber SL, and Koehler AN Chemistry & biology, 2006/05/01, Volume 13, Issue 5, p.493-504, (2006) Read More / View Supplemental Materials
Abstract
2003
Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.Koehler, AN, Shamji AF, and Schreiber SL Journal of the American Chemical Society, 2003/07/16, Volume 125, Issue 28, p.8420-1, (2003) Read More / View Supplemental Materials
Abstract
Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands.Barnes-Seeman, D., Park SB, Koehler AN, and Schreiber SL Angewandte Chemie (International ed. in English), 2003/05/30, Volume 42, Issue 21, p.2376-9, (2003) Read More / View Supplemental Materials
2001
A one-bead, one-stock solution approach to chemical genetics: part 2.Clemons, PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, and Foley MA Chemistry & biology, 2001/12/01, Volume 8, Issue 12, p.1183-95, (2001) Read More / View Supplemental Materials
Abstract
1999
The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions.Glasfeld, A., Koehler AN, Schumacher MA, and Brennan RG Journal of molecular biology, 1999/08/13, Volume 291, Issue 2, p.347-61, (1999) Read More / View Supplemental Materials
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  • Showing 1-27 of 27 Results