Home>News & Publications:Scientific Publications>Scientific Publications

Scientific Publications

Search by Keyword(s)
or use Advanced Search
Found 27 results

Filters: Author is Root, DE  [Clear All Filters]

Search Results

  • Showing 1-27 of 27 Results
2013
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.Whittaker, SR, Theurillat JP, Van Allen E., Wagle N., Hsiao J., Cowley GS, Schadendorf D., Root DE, and Garraway LA Cancer discovery, 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
2012
ATARiS: Computational quantification of gene suppression phenotypes from multi-sample RNAi screens.Shao, DD, Tsherniak A., Gopal S., Weir BA, Tamayo P., Stransky N., Schumacher SE, Zack TI, Beroukhim R., Garraway LA, Margolin AA, Root DE, Hahn WC, and Mesirov J. P. Genome research, 2012/12/26, (2012) Read More / View Supplemental Materials
Abstract
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Neal JT, Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., Kuo CJ, Goessling W., et al. Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials
Abstract
The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress.Leussis, MP, Berry-Scott EM, Saito M., Jhuang H., De Haan G., Alkan O., Luce CJ, Madison JM, Sklar P., Serre T., Root DE, and Petryshen TL Biological psychiatry, 2012/12/10, (2012) Read More / View Supplemental Materials
Abstract
Cancer vulnerabilities unveiled by genomic loss.Nijhawan, D., Zack TI, Ren Y., Strickland MR, Lamothe R., Schumacher SE, Tsherniak A., Besche HC, Rosenbluh J., Shehata S., Cowley GS, Weir BA, Goldberg AL, Mesirov J. P., Root DE, Bhatia SN, Beroukhim R., and Hahn WC Cell, 2012/08/17, Volume 150, Issue 4, p.842-54, (2012) Read More / View Supplemental Materials
Abstract
Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4.Ren, Y., Cheung HW, von Maltzhan G., Agrawal A., Cowley GS, Weir BA, Boehm JS, Tamayo P., Karst AM, Liu JF, Hirsch MS, Mesirov J. P., Drapkin R., Root DE, Lo J., Fogal V., Ruoslahti E., Hahn WC, and Bhatia SN Science translational medicine, 2012/08/15, Volume 4, Issue 147, p.147ra112, (2012) Read More / View Supplemental Materials
Abstract
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Q., Goldenson B., Silver SJ, Schenone M., Dancik V., Huang Z., Wang LZ, Lewis TA, An WF, Li X., Bray MA, Thiollier C., Diebold L., Gilles L., Vokes MS, Moore CB, Bliss-Moreau M., VerPlank L., Tolliday NJ, Mishra R., et al. Cell, 2012/08/03, Volume 150, Issue 3, p.575-89, (2012) Read More / View Supplemental Materials
Abstract
2011
Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers.Cheung, HW, Du J., Boehm JS, He F., Weir BA, Wang X., Butaney M., Sequist LV, Luo B., Engelman JA, Root DE, Meyerson M., Golub T. R., Jänne PA, and Hahn WC Cancer discovery, 2011/12/01, Volume 1, Issue 7, p.608-25, (2011) Read More / View Supplemental Materials
Abstract
Systematic discovery of TLR signaling components delineates viral-sensing circuits.Chevrier, N., Mertins P., Artyomov MN, Shalek AK, Iannacone M., Ciaccio MF, Gat-Viks I., Tonti E., Degrace MM, Clauser KR, Garber M., Eisenhaure TM, Yosef N., Robinson J., Sutton A., Andersen MS, Root DE, von Andrian U., Jones RB, Park H., et al. Cell, 2011/11/11, Volume 147, Issue 4, p.853-67, (2011) Read More / View Supplemental Materials
Abstract
lincRNAs act in the circuitry controlling pluripotency and differentiation.Guttman, M., Donaghey J., Carey BW, Garber M., Grenier JK, Munson G., Young G., Lucas AB, Ach R., Bruhn L., Yang X., Amit I., Meissner A., Regev A., Rinn JL, Root DE, and Lander E. S. Nature, 2011/08/28, Volume 477, Issue 7364, p.295-300, (2011) Read More / View Supplemental Materials
Abstract
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Cheung, HW, Cowley GS, Weir BA, Boehm JS, Rusin S., Scott JA, East A., Ali LD, Lizotte PH, Wong TC, Jiang G., Hsiao J., Mermel CH, Getz G., Barretina J., Gopal S., Tamayo P., Gould J., Tsherniak A., Stransky N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/26, Volume 108, Issue 30, p.12372-7, (2011) Read More / View Supplemental Materials
Abstract
A public genome-scale lentiviral expression library of human ORFs.Yang, X., Boehm JS, Yang X., Salehi-Ashtiani K., Hao T., Shen Y., Lubonja R., Thomas SR, Alkan O., Bhimdi T., Green TM, Johannessen CM, Silver SJ, Nguyen C., Murray RR, Hieronymus H., Balcha D., Fan C., Lin C., Ghamsari L., et al. Nature methods, 2011/06/26, Volume 8, Issue 8, p.659-61, (2011) Read More / View Supplemental Materials
Abstract
2010
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.Johannessen, CM, Boehm JS, Kim SY, Thomas SR, Wardwell L., Johnson LA, Emery CM, Stransky N., Cogdill AP, Barretina J., Caponigro G., Hieronymus H., Murray RR, Salehi-Ashtiani K., Hill DE, Vidal M., Zhao JJ, Yang X., Alkan O., Kim S., et al. Nature, 2010/12/16, Volume 468, Issue 7326, p.968-72, (2010) Read More / View Supplemental Materials
Abstract
Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.Barretina, J., Taylor BS, Banerji S., Ramos AH, Lagos-Quintana M., Decarolis PL, Shah K., Socci ND, Weir BA, Ho A., Chiang DY, Reva B., Mermel CH, Getz G., Antipin Y., Beroukhim R., Major JE, Hatton C., Nicoletti R., Hanna M., et al. Nature genetics, 2010/08/01, Volume 42, Issue 8, p.715-21, (2010) Read More / View Supplemental Materials
Abstract
CK1epsilon is required for breast cancers dependent on beta-catenin activity.Kim, SY, Dunn IF, Firestein R., Gupta P., Wardwell L., Repich K., Schinzel AC, Wittner B., Silver SJ, Root DE, Boehm JS, Ramaswamy S., Lander E. S., and Hahn WC PloS one, 2010/02/01, Volume 5, Issue 2, p.e8979, (2010) Read More / View Supplemental Materials
Abstract
2009
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection.Shapira, SD, Gat-Viks I., Shum BO, Dricot A., Degrace MM, Wu L., Gupta PB, Hao T., Silver SJ, Root DE, Hill DE, Regev A., and Hacohen N. Cell, 2009/12/24, Volume 139, Issue 7, p.1255-67, (2009) Read More / View Supplemental Materials
Abstract
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.Barbie, DA, Tamayo P., Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P., Meylan E., Scholl C., Fröhling S., Chan EM, Sos ML, Michel K., Mermel C., Silver SJ, Weir BA, Reiling JH, Sheng Q., Gupta PB, et al. Nature, 2009/11/05, Volume 462, Issue 7269, p.108-12, (2009) Read More / View Supplemental Materials
Abstract
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.Amit, I., Garber M., Chevrier N., Leite AP, Donner Y., Eisenhaure T., Guttman M., Grenier JK, Li W., Zuk O., Schubert LA, Birditt B., Shay T., Goren A., Zhang X., Smith Z., Deering R., McDonald RC, Cabili M., Bernstein BE, et al. Science (New York, N.Y.), 2009/10/09, Volume 326, Issue 5950, p.257-63, (2009) Read More / View Supplemental Materials
Abstract
Proteomic and genetic approaches identify Syk as an AML target.Hahn, CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K., Schinzel AC, Ross L., Galinsky I., Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M., Hahn WC, Carr SA, Golub T. R., Kung AL, and Stegmaier K. Cancer cell, 2009/10/06, Volume 16, Issue 4, p.281-94, (2009) Read More / View Supplemental Materials
Abstract
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.Vasudevan, KM, Barbie DA, Davies MA, Rabinovsky R., McNear CJ, Kim JJ, Hennessy BT, Tseng H., Pochanard P., Kim SY, Dunn IF, Schinzel AC, Sandy P., Hoersch S., Sheng Q., Gupta PB, Boehm JS, Reiling JH, Silver S., Lu Y., et al. Cancer cell, 2009/07/07, Volume 16, Issue 1, p.21-32, (2009) Read More / View Supplemental Materials
Abstract
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning.Jones, TR, Carpenter AE, Lamprecht MR, Moffat J., Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P., and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2009/02/10, Volume 106, Issue 6, p.1826-31, (2009) Read More / View Supplemental Materials
Abstract
2008
Highly parallel identification of essential genes in cancer cells.Luo, B., Cheung HW, Subramanian A., Sharifnia T., Okamoto M., Yang X., Hinkle G., Boehm JS, Beroukhim R., Weir BA, Mermel C., Barbie DA, Awad T., Zhou X., Nguyen T., Piqani B., Li C., Golub T. R., Meyerson M., Hacohen N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/12/23, Volume 105, Issue 51, p.20380-5, (2008) Read More / View Supplemental Materials
Abstract
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.Ebert, BL, Pretz J., Bosco J., Chang CY, Tamayo P., Galili N., Raza A., Root DE, Attar E., Ellis SR, and Golub T. R. Nature, 2008/01/17, Volume 451, Issue 7176, p.335-9, (2008) Read More / View Supplemental Materials
Abstract
2007
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.Boehm, JS, Zhao JJ, Yao J., Kim SY, Firestein R., Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S., Richardson AL, Greulich H., Stewart CJ, Mulvey LA, Shen RR, Ambrogio L., Hirozane-Kishikawa T., Hill DE, Vidal M., Meyerson M., Grenier JK, et al. Cell, 2007/06/15, Volume 129, Issue 6, p.1065-79, (2007) Read More / View Supplemental Materials
Abstract
2006
Genome-scale loss-of-function screening with a lentiviral RNAi library.Root, DE, Hacohen N., Hahn WC, Lander E. S., and Sabatini DM Nature methods, 2006/09/01, Volume 3, Issue 9, p.715-9, (2006) Read More / View Supplemental Materials
Abstract
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.Moffat, J., Grueneberg DA, Yang X., Kim SY, Kloepfer AM, Hinkle G., Piqani B., Eisenhaure TM, Luo B., Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N., Hahn WC, Lander E. S., Sabatini DM, and Root DE Cell, 2006/03/24, Volume 124, Issue 6, p.1283-98, (2006) Read More / View Supplemental Materials
Abstract
  • Showing 1-27 of 27 Results