Scientific Publications

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration.Gräff, J., Kahn M., Samiei A., Gao J., Ota KT, Rei D., and Tsai LH The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013/05/22, Volume 33, Issue 21, p.8951-60, (2013) Read More / View Supplemental Materials

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Abstract

DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1.Soda, T., Frank C., Ishizuka K., Baccarella A., Park YU, Flood Z., Park SK, Sawa A., and Tsai LH Molecular psychiatry, 2013/04/16, (2013) Read More / View Supplemental Materials

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Abstract

Histone acetylation: molecular mnemonics on the chromatin.Gräff, J., and Tsai LH Nature reviews. Neuroscience, 2013/02/01, Volume 14, Issue 2, p.97-111, (2013) Read More / View Supplemental Materials

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Abstract

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Fass, DM, Reis SA, Ghosh B., Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W., Barker DD, Mazitschek R., Schreiber SL, Tsai LH, and Haggarty SJ Neuropharmacology, 2012/07/04, (2012) Read More / View Supplemental Materials

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Abstract

An epigenetic blockade of cognitive functions in the neurodegenerating brain.Gräff, J., Rei D., Guan JS, Wang WY, Seo J., Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M., Su SC, Samiei A., Joseph N., Haggarty SJ, Delalle I., and Tsai LH Nature, 2012/02/29, (2012) Read More / View Supplemental Materials

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Abstract

Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development.Singh, KK, De Rienzo G., Drane L., Mao Y., Flood Z., Madison J., Ferreira M., Bergen S., King C., Sklar P., Sive H., and Tsai LH Neuron, 2011/11/17, Volume 72, Issue 4, p.545-58, (2011) Read More / View Supplemental Materials

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Abstract

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1).Giusti-Rodríguez, P., Gao J., Gräff J., Rei D., Soda T., and Tsai LH The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011/11/02, Volume 31, Issue 44, p.15751-6, (2011) Read More / View Supplemental Materials

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Abstract

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.Mao, Y., Ge X., Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C., Berry EM, Soda T., Singh KK, Biechele T., Petryshen TL, Moon RT, Haggarty SJ, and Tsai LH Cell, 2009/03/20, Volume 136, Issue 6, p.1017-31, (2009) Read More / View Supplemental Materials

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Abstract