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2016
Revealing disease-associated pathways by network integration of untargeted metabolomics.Pirhaji, L., Milani P., Leidl M., Curran T., Avila-Pacheco J., Clish CB, White FM, Saghatelian A., and Fraenkel E. Nature methods, 2016/08/01, (2016) Read More / View Supplemental Materials
Abstract
An exome array study of the plasma metabolome.Rhee, EP, Yang Q., Yu B., Liu X., Cheng S., Deik A., Pierce KA, Bullock K., Ho JE, Levy D., Florez JC, Kathiresan S., Larson MG, Vasan RS, Clish CB, Wang TJ, Boerwinkle E., O'Donnell CJ, and Gerszten RE Nature communications, 2016/07/25, Volume 7, p.12360, (2016) Read More / View Supplemental Materials
Abstract
Targeting MTHFD2 in acute myeloid leukemia.Pikman, Y., Puissant A., Alexe G., Furman A., Chen LM, Frumm SM, Ross L., Fenouille N., Bassil CF, Lewis CA, Ramos A., Gould J., Stone RM, DeAngelo DJ, Galinsky I., Clish CB, Kung AL, Hemann MT, Vander Heiden MG, Banerji V., et al. The Journal of experimental medicine, 2016/06/20, (2016) Read More / View Supplemental Materials
Abstract
Mitochondrial dysfunction remodels one-carbon metabolism in human cells.Bao, XR, Ong SE, Goldberger O., Peng J., Sharma R., Thompson DA, Vafai SB, Cox AG, Marutani E., Ichinose F., Goessling W., Regev A., Carr SA, Clish CB, and Mootha VK eLife, 2016/06/16, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.Yuan, C., Clish CB, Wu C., Mayers JR, Kraft P., Townsend MK, Zhang M., Tworoger SS, Bao Y., Qian ZR, Rubinson DA, Ng K., Giovannucci EL, Ogino S., Stampfer MJ, Gaziano JM, Ma J., Sesso HD, Anderson GL, Cochrane BB, et al. Journal of the National Cancer Institute, 2016/06/01, Volume 108, Issue 6, (2016) Read More / View Supplemental Materials
Abstract
Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study.Rhee, EP, Clish CB, Wenger J., Roy J., Elmariah S., Pierce KA, Bullock K., Anderson AH, Gerszten RE, and Feldman HI American journal of nephrology, 2016/05/13, Volume 43, Issue 5, p.366-374, (2016) Read More / View Supplemental Materials
Abstract
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.Rothhammer, V., Mascanfroni ID, Bunse L., Takenaka MC, Kenison JE, Mayo L., Chao CC, Patel B., Yan R., Blain M., Alvarez JI, Kébir H., Anandasabapathy N., Izquierdo G., Jung S., Obholzer N., Pochet N., Clish CB, Prinz M., Prat A., et al. Nature medicine, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis.Guasch-Ferré, M., Hruby A., Toledo E., Clish CB, Martínez-González MA, Salas-Salvadó J., and Hu FB Diabetes care, 2016/05/01, Volume 39, Issue 5, p.833-46, (2016) Read More / View Supplemental Materials
Abstract
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.Dayton, TL, Gocheva V., Miller KM, Israelsen WJ, Bhutkar A., Clish CB, Davidson SM, Luengo A., Bronson RT, Jacks T., and Vander Heiden MG Genes & development, 2016/04/28, (2016) Read More / View Supplemental Materials
Abstract
Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.Guasch-Ferré, M., Zheng Y., Ruiz-Canela M., Hruby A., Martínez-González MA, Clish CB, Corella D., Estruch R., Ros E., Fitó M., Dennis C., Morales-Gil IM, Arós F., Fiol M., Lapetra J., Serra-Majem L., Hu FB, and Salas-Salvadó J. The American journal of clinical nutrition, 2016/04/20, (2016) Read More / View Supplemental Materials
Abstract
Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles.Allegretti, JR, Kearney S., Li N., Bogart E., Bullock K., Gerber GK, Bry L., Clish CB, Alm E., and Korzenik JR Alimentary pharmacology & therapeutics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.Chouchani, ET, Kazak L., Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J., Pierce KA, Laznik-Bogoslavski D., Vetrivelan R., Clish CB, Robinson AJ, Gygi SP, and Spiegelman BM Nature, 2016/03/30, (2016) Read More / View Supplemental Materials
Abstract
PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.Tran, MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W., Clish CB, Stillman IE, Karumanchi SA, Rhee EP, and Parikh SM Nature, 2016/03/24, Volume 531, Issue 7595, p.528-32, (2016) Read More / View Supplemental Materials
Abstract
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.Joyal, JS, Sun Y., Gantner ML, Shao Z., Evans LP, Saba N., Fredrick T., Burnim S., Kim JS, Patel G., Juan AM, Hurst CG, Hatton CJ, Cui Z., Pierce KA, Bherer P., Aguilar E., Powner MB, Vevis K., Boisvert M., et al. Nature medicine, 2016/03/14, (2016) Read More / View Supplemental Materials
Abstract
Protective Effects of the Mediterranean Diet on Type 2 Diabetes and Metabolic Syndrome.Salas-Salvadó, J., Guasch-Ferré M., Lee CH, Estruch R., Clish CB, and Ros E. The Journal of nutrition, 2016/03/09, (2016) Read More / View Supplemental Materials
Abstract
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.Olenchock, BA, Moslehi J., Baik AH, Davidson SM, Williams J., Gibson WJ, Pierce KA, Miller CM, Hanse EA, Kelekar A., Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, and Kaelin WG Jr Cell, 2016/02/25, Volume 164, Issue 5, p.884-95, (2016) Read More / View Supplemental Materials
Abstract
Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.Ruiz-Canela, M., Toledo E., Clish CB, Hruby A., Liang L., Salas-Salvadó J., Razquin C., Corella D., Estruch R., Ros E., Fitó M., Gómez-Gracia E., Arós F., Fiol M., Lapetra J., Serra-Majem L., Martínez-González MA, and Hu FB Clinical chemistry, 2016/02/17, (2016) Read More / View Supplemental Materials
Abstract
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Kryukov, GV, Wilson FH, Ruth JR, Paulk J., Tsherniak A., Marlow SE, Vazquez F., Weir BA, Fitzgerald ME, Tanaka M., Bielski CM, Scott JM, Dennis C., Cowley GS, Boehm JS, Root DE, Golub T. R., Clish CB, Bradner JE, Hahn WC, et al. Science (New York, N.Y.), 2016/02/11, (2016) Read More / View Supplemental Materials
Abstract
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.Davidson, SM, Papagiannakopoulos T., Olenchock BA, Heyman JE, Keibler MA, Luengo A., Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L., Chin CR, Stephanopolous G., Mott BT, Jacks T., Clish CB, and Vander Heiden MG Cell metabolism, 2016/02/03, (2016) Read More / View Supplemental Materials
Abstract
Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension.Lewis, GD, Ngo D., Hemnes AR, Farrell L., Domos C., Pappagianopoulos PP, Dhakal BP, Souza A., Shi X., Pugh ME, Beloiartsev A., Sinha S., Clish CB, and Gerszten RE Journal of the American College of Cardiology, 2016/01/19, Volume 67, Issue 2, p.174-89, (2016) Read More / View Supplemental Materials
Abstract
Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes.Ho, JE, Larson MG, Ghorbani A., Cheng S., Chen MH, Keyes M., Rhee EP, Clish CB, Vasan RS, Gerszten RE, and Wang TJ PloS one, 2016/01/01, Volume 11, Issue 2, p.e0148361, (2016) Read More / View Supplemental Materials
Abstract
2015
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.Rees, MG, Seashore-Ludlow B., Cheah JH, Adams DJ, Price EV, Gill S., Javaid S., Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B., Li A., Montgomery P., Kotz JD, Hon CS, Munoz B., Liefeld T., Dančík V., Haber DA, et al. Nature chemical biology, 2015/12/14, (2015) Read More / View Supplemental Materials
Abstract
CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity.Wang, C., Yosef N., Gaublomme J., Wu C., Lee Y., Clish CB, Kaminski J., Xiao S., Zu Horste GM, Pawlak M., Kishi Y., Joller N., Karwacz K., Zhu C., Ordovas-Montanes M., Madi A., Wortman I., Miyazaki T., Sobel RA, Park H., et al. Cell, 2015/11/18, (2015) Read More / View Supplemental Materials
Abstract
A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome.Thompson Legault, J., Strittmatter L., Tardif J., Sharma R., Tremblay-Vaillancourt V., Aubut C., Boucher G., Clish CB, Cyr D., Daneault C., Waters PJ, LSFC Consortium, Vachon L., Morin C., Laprise C., Rioux JD, Mootha VK, and Des Rosiers C. Cell reports, 2015/11/03, Volume 13, Issue 5, p.981-9, (2015) Read More / View Supplemental Materials
Abstract
Metabolomics: an emerging but powerful tool for precision medicine.Clish, CB Cold Spring Harbor molecular case studies, 2015/10/01, Volume 1, Issue 1, p.a000588, (2015) Read More / View Supplemental Materials
Abstract
Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Matheson, NJ, Sumner J., Wals K., Rapiteanu R., Weekes MP, Vigan R., Weinelt J., Schindler M., Antrobus R., Costa AS, Frezza C., Clish CB, Neil SJ, and Lehner PJ Cell host & microbe, 2015/09/29, (2015) Read More / View Supplemental Materials
Abstract
The metabolomics of asthma control: a promising link between genetics and disease.McGeachie, MJ, Dahlin A., Qiu W., Croteau-Chonka DC, Savage J., Wu AC, Wan ES, Sordillo JE, Al-Garawi A., Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Raby BA, Weiss S., Clish CB, and Lasky-Su JA Immunity, inflammation and disease, 2015/09/01, Volume 3, Issue 3, p.224-38, (2015) Read More / View Supplemental Materials
Abstract
Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.Oldham, WM, Clish CB, Yang Y., and Loscalzo J. Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.291-303, (2015) Read More / View Supplemental Materials
Abstract
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.Ma, S., Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R., Lewis KN, Park TJ, Miller RA, Clish CB, and Gladyshev VN Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.332-43, (2015) Read More / View Supplemental Materials
Abstract
A roadmap for interpreting (13)C metabolite labeling patterns from cells.Buescher, JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H., Clish CB, DeBerardinis RJ, Feron O., Frezza C., Ghesquiere B., Gottlieb E., Hiller K., Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C., et al. Current opinion in biotechnology, 2015/08/01, Volume 34, p.189-201, (2015) Read More / View Supplemental Materials
Abstract
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.Graham, DB, Becker CE, Doan A., Goel G., Villablanca EJ, Knights D., Mok A., Ng AC, Doench JG, Root DE, Clish CB, and Xavier RJ Nature communications, 2015/07/21, Volume 6, p.7838, (2015) Read More / View Supplemental Materials
Abstract
Cross-sectional examination of metabolites and metabolic phenotypes in uremia.Kalim, S., Clish CB, Deferio JJ, Ortiz G., Moffet AS, Gerszten RE, Thadhani R., and Rhee EP BMC nephrology, 2015/07/07, Volume 16, p.98, (2015) Read More / View Supplemental Materials
Abstract
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.Mascanfroni, ID, Takenaka MC, Yeste A., Patel B., Wu Y., Kenison JE, Siddiqui S., Basso AS, Otterbein LE, Pardoll DM, Pan F., Priel A., Clish CB, Robson SC, and Quintana FJ Nature medicine, 2015/06/01, Volume 21, Issue 6, p.638-46, (2015) Read More / View Supplemental Materials
Abstract
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.Herman, JD, Pepper LR, Cortese JF, Estiu G., Galinsky K., Zuzarte-Luis V., Derbyshire ER, Ribacke U., Lukens AK, Santos SA, Patel V., Clish CB, Sullivan WJ Jr, Zhou H., Bopp SE, Schimmel P., Lindquist S., Clardy J., Mota MM, Keller TL, et al. Science translational medicine, 2015/05/20, Volume 7, Issue 288, p.288ra77, (2015) Read More / View Supplemental Materials
Abstract
Distinct metabolomic signatures are associated with longevity in humans.Cheng, S., Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A., Magnusson M., Souza AL, Deik AA, Pierce KA, Bullock K., O'Donnell CJ, Melander O., Clish CB, Vasan RS, Gerszten RE, and Wang TJ Nature communications, 2015/04/13, Volume 6, p.6791, (2015) Read More / View Supplemental Materials
Abstract
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.Miao, J., Ling AV, Croce KJ, and Clish CB Nature communications, 2015/04/07, Volume 6, p.6498, (2015) Read More / View Supplemental Materials
Abstract
The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.Kostic, AD, Gevers D., Siljander H., Vatanen T., Hyötyläinen T., Hämäläinen AM, Peet A., Tillmann V., Pöhö P., Mattila I., Lähdesmäki H., Franzosa EA, Vaarala O., de Goffau M., Harmsen H., Ilonen J., Virtanen SM, Clish CB, Orešič M., Huttenhower C., et al. Cell host & microbe, 2015/02/11, Volume 17, Issue 2, p.260-73, (2015) Read More / View Supplemental Materials
Abstract
Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.Lennerz, BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, and Mootha VK Molecular genetics and metabolism, 2015/01/01, Volume 114, Issue 1, p.73-9, (2015) Read More / View Supplemental Materials
Abstract
HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.Carroll, JB, Deik A., Fossale E., Weston RM, Guide JR, Arjomand J., Kwak S., Clish CB, and Macdonald ME PloS one, 2015/01/01, Volume 10, Issue 8, p.e0134465, (2015) Read More / View Supplemental Materials
Abstract
2014
Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension.Rhee, EP, Clish CB, Pierce KA, Saad A., Lerman LO, and Textor SC Journal of hypertension, 2014/12/08, (2014) Read More / View Supplemental Materials
Abstract
5-hydroxymethylcytosine is not present in appreciable quantities in Arabidopsis DNA.Erdmann, RM, Souza AL, Clish CB, and Gehring M. G3 (Bethesda, Md.), 2014/11/06, Volume 5, Issue 1, p.1-8, (2014) Read More / View Supplemental Materials
Abstract
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.Mayers, JR, Wu C., Clish CB, Kraft P., Torrence ME, Fiske BP, Yuan C., Bao Y., Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T., Yang A., Dayton TL, Ogino S., Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J., et al. Nature medicine, 2014/10/01, Volume 20, Issue 10, p.1193-8, (2014) Read More / View Supplemental Materials
Abstract
Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.Wang, YH, Israelsen WJ, Lee D., Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, and Scadden DT Cell, 2014/09/11, Volume 158, Issue 6, p.1309-23, (2014) Read More / View Supplemental Materials
Abstract
Identification of small compound biomarkers of pituitary adenoma: a bilateral inferior petrosal sinus sampling study.Oklu, R., Deipolyi AR, Wicky S., Ergul E., Deik AA, Chen JW, Hirsch JA, Wojtkiewicz GR, and Clish CB Journal of neurointerventional surgery, 2014/09/01, Volume 6, Issue 7, p.541-6, (2014) Read More / View Supplemental Materials
Abstract
Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.Di Nardo, A., Wertz MH, Kwiatkowski E., Tsai PT, Leech JD, Greene-Colozzi E., Goto J., Dilsiz P., Talos DM, Clish CB, Kwiatkowski DJ, and Sahin M. Human molecular genetics, 2014/07/15, Volume 23, Issue 14, p.3865-74, (2014) Read More / View Supplemental Materials
Abstract
Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.Hung, CM, Calejman CM, Sanchez-Gurmaches J., Li H., Clish CB, Hettmer S., Wagers AJ, and Guertin DA Cell reports, 2014/07/10, Volume 8, Issue 1, p.256-71, (2014) Read More / View Supplemental Materials
Abstract
Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.Ren, JG, Seth P., Clish CB, Lorkiewicz PK, Higashi RM, Lane AN, Fan TW, and Sukhatme VP Scientific reports, 2014/06/24, Volume 4, p.5414, (2014) Read More / View Supplemental Materials
Abstract
Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.Avanesov, AS, Ma S., Pierce KA, Yim SH, Lee BC, Clish CB, and Gladyshev VN eLife, 2014/04/29, Volume 3, p.e02077, (2014) Read More / View Supplemental Materials
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A systematic survey of lipids across mouse tissues.Jain, M., Ngoy S., Sheth SA, Swanson RA, Rhee EP, Liao R., Clish CB, Mootha VK, and Nilsson R. American journal of physiology. Endocrinology and metabolism, 2014/04/15, Volume 306, Issue 8, p.E854-68, (2014) Read More / View Supplemental Materials
Abstract
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.Chen, WW, Birsoy K., Mihaylova MM, Snitkin H., Stasinski I., Yucel B., Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, and Sabatini DM Cell reports, 2014/04/10, Volume 7, Issue 1, p.27-34, (2014) Read More / View Supplemental Materials
Abstract
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Birsoy, K., Possemato R., Lorbeer FK, Bayraktar EC, Thiru P., Yucel B., Wang T., Chen WW, Clish CB, and Sabatini DM Nature, 2014/04/03, Volume 508, Issue 7494, p.108-12, (2014) Read More / View Supplemental Materials
Abstract
Regulation of ferroptotic cancer cell death by GPX4.Yang, WS, Sriramaratnam R., Welsch ME, Shimada K., Skouta R., Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, and Stockwell BR Cell, 2014/01/16, Volume 156, Issue 1-2, p.317-31, (2014) Read More / View Supplemental Materials
Abstract
β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.Roberts, LD, Boström P., O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A., Lee YK, Palma MJ, Calhoun S., Georgiadi A., Chen MH, Ramachandran VS, Larson MG, Bouchard C., Rankinen T., Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, et al. Cell metabolism, 2014/01/07, Volume 19, Issue 1, p.96-108, (2014) Read More / View Supplemental Materials
Abstract
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria.Herman, JD, Rice DP, Ribacke U., Silterra J., Deik AA, Moss EL, Broadbent KM, Neafsey DE, Desai MM, Clish CB, Mazitschek R., and Wirth DF Genome biology, 2014/01/01, Volume 15, Issue 11, p.511, (2014) Read More / View Supplemental Materials
Abstract
2013
Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism.Gohil, VM, Zhu L., Baker CD, Cracan V., Yaseen A., Jain M., Clish CB, Brookes PS, Bakovic M., and Mootha VK The Journal of biological chemistry, 2013/12/06, Volume 288, Issue 49, p.35387-95, (2013) Read More / View Supplemental Materials
Abstract
A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients.Kalim, S., Clish CB, Wenger J., Elmariah S., Yeh RW, Deferio JJ, Pierce K., Deik A., Gerszten RE, Thadhani R., and Rhee EP Journal of the American Heart Association, 2013/12/05, Volume 2, Issue 6, p.e000542, (2013) Read More / View Supplemental Materials
Abstract
Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus.Walford, GA, Davis J., Warner AS, Ackerman RJ, Billings LK, Chamarthi B., Fanelli RR, Hernandez AM, Huang C., Khan SQ, Littleton KR, Lo J., McCarthy RM, Rhee EP, Deik A., Stolerman E., Taylor A., Hudson MS, Wang TJ, Altshuler D., et al. Metabolism: clinical and experimental, 2013/12/01, Volume 62, Issue 12, p.1772-8, (2013) Read More / View Supplemental Materials
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Reproducibility of metabolomic profiles among men and women in 2 large cohort studies.Townsend, MK, Clish CB, Kraft P., Wu C., Souza AL, Deik AA, Tworoger SS, and Wolpin BM Clinical chemistry, 2013/11/01, Volume 59, Issue 11, p.1657-67, (2013) Read More / View Supplemental Materials
Abstract
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.Israelsen, WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G., Li J., Yu Y., Sasaki M., Horner JW, Burga LN, Xie J., Jurczak MJ, Depinho RA, Clish CB, Jacks T., Kibbey RG, Wulf GM, Di Vizio D., Mills GB, et al. Cell, 2013/10/10, Volume 155, Issue 2, p.397-409, (2013) Read More / View Supplemental Materials
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2-Aminoadipic acid is a biomarker for diabetes risk.Wang, TJ, Ngo D., Psychogios N., Dejam A., Larson MG, Vasan RS, Ghorbani A., O'Sullivan J., Cheng S., Rhee EP, Sinha S., McCabe E., Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M., Pierce KA, Souza AL, Yu Y., et al. The Journal of clinical investigation, 2013/10/01, Volume 123, Issue 10, p.4309-17, (2013) Read More / View Supplemental Materials
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Metabolite profiles during oral glucose challenge.Ho, JE, Larson MG, Vasan RS, Ghorbani A., Cheng S., Rhee EP, Florez JC, Clish CB, Gerszten RE, and Wang TJ Diabetes, 2013/08/01, Volume 62, Issue 8, p.2689-98, (2013) Read More / View Supplemental Materials
Abstract
A combined epidemiologic and metabolomic approach improves CKD prediction.Rhee, EP, Clish CB, Ghorbani A., Larson MG, Elmariah S., McCabe E., Yang Q., Cheng S., Pierce K., Deik A., Souza AL, Farrell L., Domos C., Yeh RW, Palacios I., Rosenfield K., Vasan RS, Florez JC, Wang TJ, Fox CS, et al. Journal of the American Society of Nephrology : JASN, 2013/07/01, Volume 24, Issue 8, p.1330-8, (2013) Read More / View Supplemental Materials
Abstract
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.Jiang, D., Zhao L., Clish CB, and Clapham DE Proceedings of the National Academy of Sciences of the United States of America, 2013/06/11, Volume 110, Issue 24, p.E2249-54, (2013) Read More / View Supplemental Materials
Abstract
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.Jeong, SM, Xiao C., Finley LW, Lahusen T., Souza AL, Pierce K., Li YH, Wang X., Laurent G., German NJ, Xu X., Li C., Wang RH, Lee J., Csibi A., Cerione R., Blenis J., Clish CB, Kimmelman A., Deng CX, et al. Cancer cell, 2013/04/15, Volume 23, Issue 4, p.450-63, (2013) Read More / View Supplemental Materials
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PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.Vazquez, F., Lim JH, Chim H., Bhalla K., Girnun G., Pierce K., Clish CB, Granter SR, Widlund HR, Spiegelman BM, and Puigserver P. Cancer cell, 2013/03/18, Volume 23, Issue 3, p.287-301, (2013) Read More / View Supplemental Materials
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Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.McCormack, SE, Shaham O., McCarthy MA, Deik AA, Wang TJ, Gerszten RE, Clish CB, Mootha VK, Grinspoon SK, and Fleischman A. Pediatric obesity, 2013/02/01, Volume 8, Issue 1, p.52-61, (2013) Read More / View Supplemental Materials
Abstract
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Birsoy, K., Wang T., Possemato R., Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y., Peterson TR, Carette JE, Brummelkamp TR, Clish CB, and Sabatini DM Nature genetics, 2013/01/01, Volume 45, Issue 1, p.104-8, (2013) Read More / View Supplemental Materials
Abstract
2012
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.Dominy JE, Jr, Lee Y., Jedrychowski MP, Chim H., Jurczak MJ, Camporez JP, Ruan HB, Feldman J., Pierce K., Mostoslavsky R., Denu JM, Clish CB, Yang X., Shulman GI, Gygi SP, and Puigserver P. Molecular cell, 2012/12/28, Volume 48, Issue 6, p.900-13, (2012) Read More / View Supplemental Materials
Abstract
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.Kalaitzidis, D., Sykes SM, Wang Z., Punt N., Tang Y., Ragu C., Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D., Gilliland DG, Scadden DT, Guertin DA, and Armstrong SA Cell stem cell, 2012/09/07, Volume 11, Issue 3, p.429-39, (2012) Read More / View Supplemental Materials
Abstract
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.Jain, M., Nilsson R., Sharma S., Madhusudhan N., Kitami T., Souza AL, Kafri R., Kirschner MW, Clish CB, and Mootha VK Science (New York, N.Y.), 2012/05/25, Volume 336, Issue 6084, p.1040-4, (2012) Read More / View Supplemental Materials
Abstract
Metabolite profiling identifies pathways associated with metabolic risk in humans.Cheng, S., Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D., Palma MJ, Roberts LD, Dejam A., Souza AL, Deik AA, Magnusson M., Fox CS, O'Donnell CJ, Vasan RS, Melander O., Clish CB, Gerszten RE, and Wang TJ Circulation, 2012/05/08, Volume 125, Issue 18, p.2222-31, (2012) Read More / View Supplemental Materials
Abstract
Targeted metabolomics.Roberts, LD, Souza AL, Gerszten RE, and Clish CB Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], 2012/04/01, Volume Chapter 30, p.Unit 30.2.1-24, (2012) Read More / View Supplemental Materials
Abstract
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.Leoni, V., Strittmatter L., Zorzi G., Zibordi F., Dusi S., Garavaglia B., Venco P., Caccia C., Souza AL, Deik A., Clish CB, Rimoldi M., Ciusani E., Bertini E., Nardocci N., Mootha VK, and Tiranti V. Molecular genetics and metabolism, 2012/03/01, Volume 105, Issue 3, p.463-71, (2012) Read More / View Supplemental Materials
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Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction.Finley, LW, Lee J., Souza A., Desquiret-Dumas V., Bullock K., Rowe GC, Procaccio V., Clish CB, Arany Z., and Haigis MC Proceedings of the National Academy of Sciences of the United States of America, 2012/02/21, Volume 109, Issue 8, p.2931-6, (2012) Read More / View Supplemental Materials
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Programming human pluripotent stem cells into white and brown adipocytes.Ahfeldt, T., Schinzel RT, Lee YK, Hendrickson D., Kaplan A., Lum DH, Camahort R., Xia F., Shay J., Rhee EP, Clish CB, Deo RC, Shen T., Lau FH, Cowley A., Mowrer G., Al-Siddiqi H., Nahrendorf M., Musunuru K., Gerszten RE, et al. Nature cell biology, 2012/01/15, Volume 14, Issue 2, p.209-19, (2012) Read More / View Supplemental Materials
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2011
Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.Dong, CK, Urgaonkar S., Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V., Ross L., Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M., Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J., and Mazitschek R. Chemistry & biology, 2011/12/23, Volume 18, Issue 12, p.1602-10, (2011) Read More / View Supplemental Materials
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A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.Reiling, JH, Clish CB, Carette JE, Varadarajan M., Brummelkamp TR, and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11756-65, (2011) Read More / View Supplemental Materials
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A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like.Kelly, TJ, Souza AL, Clish CB, and Puigserver P. Molecular and cellular biology, 2011/07/01, Volume 31, Issue 13, p.2696-706, (2011) Read More / View Supplemental Materials
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Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.Rhee, EP, Cheng S., Larson MG, Walford GA, Lewis GD, McCabe E., Yang E., Farrell L., Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, and Gerszten RE The Journal of clinical investigation, 2011/04/01, Volume 121, Issue 4, p.1402-11, (2011) Read More / View Supplemental Materials
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Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials
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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.Finley, LW, Carracedo A., Lee J., Souza A., Egia A., Zhang J., Teruya-Feldstein J., Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, and Haigis MC Cancer cell, 2011/03/08, Volume 19, Issue 3, p.416-28, (2011) Read More / View Supplemental Materials
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2010
Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.Ren, JG, Seth P., Everett P., Clish CB, and Sukhatme VP PloS one, 2010/09/02, Volume 5, Issue 9, (2010) Read More / View Supplemental Materials
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Activation of a metabolic gene regulatory network downstream of mTOR complex 1.Düvel, K., Yecies JL, Menon S., Raman P., Lipovsky AI, Souza AL, Triantafellow E., Ma Q., Gorski R., Cleaver S., Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, and Manning BD Molecular cell, 2010/07/30, Volume 39, Issue 2, p.171-83, (2010) Read More / View Supplemental Materials
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Metabolite profiling identifies markers of uremia.Rhee, EP, Souza A., Farrell L., Pollak MR, Lewis GD, Steele DJ, Thadhani R., Clish CB, Greka A., and Gerszten RE Journal of the American Society of Nephrology : JASN, 2010/06/01, Volume 21, Issue 6, p.1041-1051, (2010) Read More / View Supplemental Materials
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Metabolic signatures of exercise in human plasma.Lewis, GD, Farrell L., Wood MJ, Martinovic M., Arany Z., Rowe GC, Souza A., Cheng S., McCabe EL, Yang E., Shi X., Deo R., Roth FP, Asnani A., Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, et al. Science translational medicine, 2010/05/26, Volume 2, Issue 33, p.33ra37, (2010) Read More / View Supplemental Materials
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Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.Gohil, VM, Sheth SA, Nilsson R., Wojtovich AP, Lee JH, Perocchi F., Chen W., Clish CB, Ayata C., Brookes PS, and Mootha VK Nature biotechnology, 2010/03/01, Volume 28, Issue 3, p.249-55, (2010) Read More / View Supplemental Materials
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A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells.Shaham, O., Slate NG, Goldberger O., Xu Q., Ramanathan A., Souza AL, Clish CB, Sims KB, and Mootha VK Proceedings of the National Academy of Sciences of the United States of America, 2010/01/26, Volume 107, Issue 4, p.1571-5, (2010) Read More / View Supplemental Materials
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The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Zhong, L., D'Urso A., Toiber D., Sebastian C., Henry RE, Vadysirisack DD, Guimaraes A., Marinelli B., Wikstrom JD, Nir T., Clish CB, Vaitheesvaran B., Iliopoulos O., Kurland I., Dor Y., Weissleder R., Shirihai OS, Ellisen LW, Espinosa JM, and Mostoslavsky R. Cell, 2010/01/22, Volume 140, Issue 2, p.280-93, (2010) Read More / View Supplemental Materials
Abstract
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