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2014
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.Swiech, L., Heidenreich M., Banerjee A., Habib N., Li Y., Trombetta J., Sur M., and Zhang F. Nature biotechnology, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.Platt, RJ, Chen S., Zhou Y., Yim MJ, Swiech L., Kempton HR, Dahlman JE, Parnas O., Eisenhaure TM, Jovanovic M., Graham DB, Jhunjhunwala S., Heidenreich M., Xavier RJ, Langer R., Anderson DG, Hacohen N., Regev A., Feng G., Sharp PA, et al. Cell, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.Wagner, JC, Platt RJ, Goldfless SJ, Zhang F., and Niles JC Nature methods, 2014/08/10, (2014) Read More / View Supplemental Materials
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CRISPR-mediated direct mutation of cancer genes in the mouse liver.Xue, W., Chen S., Yin H., Tammela T., Papagiannakopoulos T., Joshi NS, Cai W., Yang G., Bronson R., Crowley DG, Zhang F., Anderson DG, Sharp PA, and Jacks T. Nature, 2014/08/06, (2014) Read More / View Supplemental Materials
Abstract
Improved vectors and genome-wide libraries for CRISPR screening.Sanjana, NE, Shalem O., and Zhang F. Nature methods, 2014/07/30, Volume 11, Issue 8, p.783-4, (2014) Read More / View Supplemental Materials
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites.Schwartz, S., Mumbach MR, Jovanovic M., Wang T., Maciag K., Bushkin GG, Mertins P., Ter-Ovanesyan D., Habib N., Cacchiarelli D., Sanjana NE, Freinkman E., Pacold ME, Satija R., Mikkelsen TS, Hacohen N., Zhang F., Carr SA, Lander E. S., and Regev A. Cell reports, 2014/06/25, (2014) Read More / View Supplemental Materials
Abstract
Development and Applications of CRISPR-Cas9 for Genome Engineering.Hsu, PD, Lander E. S., and Zhang F. Cell, 2014/06/05, Volume 157, Issue 6, p.1262-1278, (2014) Read More / View Supplemental Materials
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Global microRNA depletion suppresses tumor angiogenesis.Chen, S., Xue Y., Wu X., Le C., Bhutkar A., Bell EL, Zhang F., Langer R., and Sharp PA Genes & development, 2014/05/15, Volume 28, Issue 10, p.1054-67, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.Wu, X., Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S., Chen S., Jaenisch R., Zhang F., and Sharp PA Nature biotechnology, 2014/04/20, (2014) Read More / View Supplemental Materials
Abstract
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
Abstract
Crystal structure of cas9 in complex with guide RNA and target DNA.Nishimasu, H., Ran FA, Hsu PD, Konermann S., Shehata SI, Dohmae N., Ishitani R., Zhang F., and Nureki O. Cell, 2014/02/27, Volume 156, Issue 5, p.935-49, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
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RNA-Guided Genome Editing of Mammalian Cells.Pyzocha, NK, Ran FA, Hsu PD, and Zhang F. Methods in molecular biology (Clifton, N.J.), 2014/01/01, Volume 1114, p.269-77, (2014) Read More / View Supplemental Materials
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2013
Genome engineering using the CRISPR-Cas9 system.Ran, FA, Hsu PD, Wright J., Agarwala V., Scott DA, and Zhang F. Nature protocols, 2013/11/01, Volume 8, Issue 11, p.2281-308, (2013) Read More / View Supplemental Materials
Abstract
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity.Ran, FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S., Trevino AE, Scott DA, Inoue A., Matoba S., Zhang Y., and Zhang F. Cell, 2013/09/12, Volume 154, Issue 6, p.1380-9, (2013) Read More / View Supplemental Materials
Abstract
Optical control of mammalian endogenous transcription and epigenetic states.Konermann, S., Brigham MD, Trevino AE, Hsu PD, Heidenreich M., Cong L., Platt RJ, Scott DA, Church GM, and Zhang F. Nature, 2013/08/22, Volume 500, Issue 7463, p.472-6, (2013) Read More / View Supplemental Materials
Abstract
DNA targeting specificity of RNA-guided Cas9 nucleases.Hsu, PD, Scott DA, Weinstein JA, Ran FA, Konermann S., Agarwala V., Li Y., Fine EJ, Wu X., Shalem O., Cradick TJ, Marraffini LA, Bao G., and Zhang F. Nature biotechnology, 2013/07/21, (2013) Read More / View Supplemental Materials
Abstract
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.Bikard, D., Jiang W., Samai P., Hochschild A., Zhang F., and Marraffini LA Nucleic acids research, 2013/06/12, (2013) Read More / View Supplemental Materials
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Multiplex Genome Engineering Using CRISPR/Cas Systems.Cong, L., Ran FA, Cox D., Lin S., Barretto R., Habib N., Hsu PD, Wu X., Jiang W., Marraffini LA, and Zhang F. Science (New York, N.Y.), 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
2012
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains.Cong, L., Zhou R., Kuo YC, Cunniff M., and Zhang F. Nature communications, 2012/07/24, Volume 3, p.968, (2012) Read More / View Supplemental Materials
Abstract
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers.Briggs, AW, Rios X., Chari R., Yang L., Zhang F., Mali P., and Church GM Nucleic acids research, 2012/06/26, (2012) Read More / View Supplemental Materials
Abstract
A transcription activator-like effector toolbox for genome engineering.Sanjana, NE, Cong L., Zhou Y., Cunniff MM, Feng G., and Zhang F. Nature protocols, 2012/01/05, Volume 7, Issue 1, p.171-92, (2012) Read More / View Supplemental Materials
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2011
The microbial opsin family of optogenetic tools.Zhang, F., Vierock J., Yizhar O., Fenno LE, Tsunoda S., Kianianmomeni A., Prigge M., Berndt A., Cushman J., Polle J., Magnuson J., Hegemann P., and Deisseroth K. Cell, 2011/12/23, Volume 147, Issue 7, p.1446-57, (2011) Read More / View Supplemental Materials
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  • Showing 1-23 of 23 Results