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2016
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.Nott, A., Cheng J., Gao F., Lin YT, Gjoneska E., Ko T., Minhas P., Zamudio AV, Meng J., Zhang F., Jin P., and Tsai LH Nature neuroscience, 2016/07/18, (2016) Read More / View Supplemental Materials
Abstract
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.Abudayyeh, OO, Gootenberg JS, Konermann S., Joung J., Slaymaker IM, Cox DB, Shmakov S., Makarova KS, Semenova E., Minakhin L., Severinov K., Regev A., Lander E. S., Koonin EV, and Zhang F. Science (New York, N.Y.), 2016/06/02, (2016) Read More / View Supplemental Materials
Abstract
An RNA-aptamer-based two-color CRISPR labeling system.Wang, S., Hsu J., Zhang F., and Zhuang X. Scientific reports, 2016/05/27, Volume 6, p.26857, (2016) Read More / View Supplemental Materials
Abstract
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.Yamano, T., Nishimasu H., Zetsche B., Hirano H., Slaymaker IM, Li Y., Fedorova I., Nakane T., Makarova KS, Koonin EV, Ishitani R., Zhang F., and Nureki O. Cell, 2016/04/21, (2016) Read More / View Supplemental Materials
Abstract
Hypoxia as a therapy for mitochondrial disease.Jain, IH, Zazzeron L., Goli R., Alexa K., Schatzman-Bone S., Dhillon H., Goldberger O., Peng J., Shalem O., Sanjana NE, Zhang F., Goessling W., Zapol WM, and Mootha VK Science (New York, N.Y.), 2016/02/25, (2016) Read More / View Supplemental Materials
Abstract
Structure and Engineering of Francisella novicida Cas9.Hirano, H., Gootenberg JS, Horii T., Abudayyeh OO, Kimura M., Hsu PD, Nakane T., Ishitani R., Hatada I., Zhang F., Nishimasu H., and Nureki O. Cell, 2016/02/10, (2016) Read More / View Supplemental Materials
Abstract
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.Zhou, Y., Kaiser T., Monteiro P., Zhang X., Van der Goes MS, Wang D., Barak B., Zeng M., Li C., Lu C., Wells M., Amaya A., Nguyen S., Lewis M., Sanjana N., Zhou Y., Zhang M., Zhang F., Fu Z., and Feng G. Neuron, 2016/01/06, Volume 89, Issue 1, p.147-62, (2016) Read More / View Supplemental Materials
Abstract
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Klionsky, DJ, Abdelmohsen K., Abe A., Abedin MJ, Abeliovich H., Acevedo Arozena A., Adachi H., Adams CM, Adams PD, Adeli K., Adhihetty PJ, Adler SG, Agam G., Agarwal R., Aghi MK, Agnello M., Agostinis P., Aguilar PV, Aguirre-Ghiso J., Airoldi EM, et al. Autophagy, 2016/01/02, Volume 12, Issue 1, p.1-222, (2016) Read More / View Supplemental Materials
Applications of CRISPR-Cas systems in neuroscience.Heidenreich, M., and Zhang F. Nature reviews. Neuroscience, 2016/01/01, Volume 17, Issue 1, p.36-44, (2016) Read More / View Supplemental Materials
Abstract
2015
In vivo gene editing in dystrophic mouse muscle and muscle stem cells.Tabebordbar, M., Zhu K., Cheng JK, Chew WL, Widrick JJ, Yan WX, Maesner C., Wu EY, Xiao R., Ran FA, Cong L., Zhang F., Vandenberghe LH, Church GM, and Wagers AJ Science (New York, N.Y.), 2015/12/31, (2015) Read More / View Supplemental Materials
Abstract
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.Nelson, CE, Hakim CH, Ousterout DG, Thakore PI, Moreb EA, Rivera RM, Madhavan S., Pan X., Ran FA, Yan WX, Asokan A., Zhang F., Duan D., and Gersbach CA Science (New York, N.Y.), 2015/12/31, (2015) Read More / View Supplemental Materials
Abstract
Rationally engineered Cas9 nucleases with improved specificity.Slaymaker, IM, Gao L., Zetsche B., Scott DA, Yan WX, and Zhang F. Science (New York, N.Y.), 2015/12/01, (2015) Read More / View Supplemental Materials
Abstract
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.Shmakov, S., Abudayyeh OO, Makarova KS, Wolf YI, Gootenberg JS, Semenova E., Minakhin L., Joung J., Konermann S., Severinov K., Zhang F., and Koonin EV Molecular cell, 2015/11/05, Volume 60, Issue 3, p.385-97, (2015) Read More / View Supplemental Materials
Abstract
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease.Dahlman, JE, Abudayyeh OO, Joung J., Gootenberg JS, Zhang F., and Konermann S. Nature biotechnology, 2015/10/05, (2015) Read More / View Supplemental Materials
Abstract
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System.Zetsche, B., Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P., Volz SE, Joung J., van der Oost J., Regev A., Koonin EV, and Zhang F. Cell, 2015/09/23, (2015) Read More / View Supplemental Materials
Abstract
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.Canver, MC, Smith EC, Sher F., Pinello L., Sanjana NE, Shalem O., Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S., Kurita R., Nakamura Y., Fujiwara Y., Maeda T., Yuan GC, Zhang F., Orkin SH, and Bauer DE Nature, 2015/09/16, (2015) Read More / View Supplemental Materials
Abstract
Crystal Structure of Staphylococcus aureus Cas9.Nishimasu, H., Cong L., Yan WX, Ran FA, Zetsche B., Li Y., Kurabayashi A., Ishitani R., Zhang F., and Nureki O. Cell, 2015/08/27, Volume 162, Issue 5, p.1113-26, (2015) Read More / View Supplemental Materials
Abstract
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.Parnas, O., Jovanovic M., Eisenhaure TM, Herbst RH, Dixit A., Ye CJ, Przybylski D., Platt RJ, Tirosh I., Sanjana NE, Shalem O., Satija R., Raychowdhury R., Mertins P., Carr SA, Zhang F., Hacohen N., and Regev A. Cell, 2015/07/30, Volume 162, Issue 3, p.675-86, (2015) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9: Prospects and Challenges.Zhang, F. Human gene therapy, 2015/07/01, Volume 26, Issue 7, p.409-10, (2015) Read More / View Supplemental Materials
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.Ramanan, V., Shlomai A., Cox DB, Schwartz RE, Michailidis E., Bhatta A., Scott DA, Zhang F., Rice CM, and Bhatia SN Scientific reports, 2015/06/02, Volume 5, p.10833, (2015) Read More / View Supplemental Materials
Abstract
Brains, Genes, and Primates.Belmonte, JC, Callaway EM, Churchland P., Caddick SJ, Feng G., Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S., Moutri AR, Movshon JA, Okano H., Reynolds JH, Ringach D., Sejnowski TJ, Silva AC, Strick PL, Wu J., et al. Neuron, 2015/05/06, Volume 86, Issue 3, p.617-631, (2015) Read More / View Supplemental Materials
Abstract
CRISPR germline engineering--the community speaks.Bosley, KS, Botchan M., Bredenoord AL, Carroll D., Charo RA, Charpentier E., Cohen R., Corn J., Doudna J., Feng G., Greely HT, Isasi R., Ji W., Kim JS, Knoppers B., Lanphier E., Li J., Lovell-Badge R., Martin GS, Moreno J., et al. Nature biotechnology, 2015/05/01, Volume 33, Issue 5, p.478-86, (2015) Read More / View Supplemental Materials
Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.Van Allen, EM, Lui VW, Egloff AM, Goetz EM, Li H., Johnson JT, Duvvuri U., Bauman JE, Stransky N., Zeng Y., Gilbert BR, Pendleton KP, Wang L., Chiosea S., Sougnez C., Wagle N., Zhang F., Du Y., Close D., Johnston PA, et al. JAMA oncology, 2015/05/01, Volume 1, Issue 2, p.238-44, (2015) Read More / View Supplemental Materials
Abstract
High-throughput functional genomics using CRISPR-Cas9.Shalem, O., Sanjana NE, and Zhang F. Nature reviews. Genetics, 2015/05/01, Volume 16, Issue 5, p.299-311, (2015) Read More / View Supplemental Materials
Abstract
In vivo genome editing using Staphylococcus aureus Cas9.Ran, FA, Cong L., Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B., Shalem O., Wu X., Makarova KS, Koonin EV, Sharp PA, and Zhang F. Nature, 2015/04/09, Volume 520, Issue 7546, p.186-91, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.Chen, S., Sanjana NE, Zheng K., Shalem O., Lee K., Shi X., Scott DA, Song J., Pan JQ, Weissleder R., Lee H., Zhang F., and Sharp PA Cell, 2015/03/12, Volume 160, Issue 6, p.1246-60, (2015) Read More / View Supplemental Materials
Abstract
Therapeutic genome editing: prospects and challenges.Cox, DB, Platt RJ, and Zhang F. Nature medicine, 2015/02/05, Volume 21, Issue 2, p.121-131, (2015) Read More / View Supplemental Materials
Abstract
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.Liu, H., Irwanto A., Fu X., Yu G., Yu Y., Sun Y., Wang C., Wang Z., Okada Y., Low H., Li Y., Liany H., Chen M., Bao F., Li J., You J., Zhang Q., Liu J., Chu T., Andiappan AK, et al. Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
Abstract
A split-Cas9 architecture for inducible genome editing and transcription modulation.Zetsche, B., Volz SE, and Zhang F. Nature biotechnology, 2015/02/02, Volume 33, Issue 2, p.139-142, (2015) Read More / View Supplemental Materials
Genome Engineering Using CRISPR-Cas9 System.Cong, L., and Zhang F. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1239, p.197-217, (2015) Read More / View Supplemental Materials
Abstract
2014
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.Konermann, S., Brigham MD, Trevino AE, Joung J., Abudayyeh OO, Barcena C., Hsu PD, Habib N., Gootenberg JS, Nishimasu H., Nureki O., and Zhang F. Nature, 2014/12/10, (2014) Read More / View Supplemental Materials
Abstract
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.Swiech, L., Heidenreich M., Banerjee A., Habib N., Li Y., Trombetta J., Sur M., and Zhang F. Nature biotechnology, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9 knockin mice for genome editing and cancer modeling.Platt, RJ, Chen S., Zhou Y., Yim MJ, Swiech L., Kempton HR, Dahlman JE, Parnas O., Eisenhaure TM, Jovanovic M., Graham DB, Jhunjhunwala S., Heidenreich M., Xavier RJ, Langer R., Anderson DG, Hacohen N., Regev A., Feng G., Sharp PA, et al. Cell, 2014/10/09, Volume 159, Issue 2, p.440-55, (2014) Read More / View Supplemental Materials
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Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.Wagner, JC, Platt RJ, Goldfless SJ, Zhang F., and Niles JC Nature methods, 2014/08/10, (2014) Read More / View Supplemental Materials
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CRISPR-mediated direct mutation of cancer genes in the mouse liver.Xue, W., Chen S., Yin H., Tammela T., Papagiannakopoulos T., Joshi NS, Cai W., Yang G., Bronson R., Crowley DG, Zhang F., Anderson DG, Sharp PA, and Jacks T. Nature, 2014/08/06, (2014) Read More / View Supplemental Materials
Abstract
Improved vectors and genome-wide libraries for CRISPR screening.Sanjana, NE, Shalem O., and Zhang F. Nature methods, 2014/08/01, Volume 11, Issue 8, p.783-4, (2014) Read More / View Supplemental Materials
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites.Schwartz, S., Mumbach MR, Jovanovic M., Wang T., Maciag K., Bushkin GG, Mertins P., Ter-Ovanesyan D., Habib N., Cacchiarelli D., Sanjana NE, Freinkman E., Pacold ME, Satija R., Mikkelsen TS, Hacohen N., Zhang F., Carr SA, Lander E. S., and Regev A. Cell reports, 2014/06/25, (2014) Read More / View Supplemental Materials
Abstract
Development and Applications of CRISPR-Cas9 for Genome Engineering.Hsu, PD, Lander E. S., and Zhang F. Cell, 2014/06/05, Volume 157, Issue 6, p.1262-1278, (2014) Read More / View Supplemental Materials
Abstract
Global microRNA depletion suppresses tumor angiogenesis.Chen, S., Xue Y., Wu X., Le C., Bhutkar A., Bell EL, Zhang F., Langer R., and Sharp PA Genes & development, 2014/05/15, Volume 28, Issue 10, p.1054-67, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.Wu, X., Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S., Chen S., Jaenisch R., Zhang F., and Sharp PA Nature biotechnology, 2014/04/20, (2014) Read More / View Supplemental Materials
Abstract
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
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Crystal structure of cas9 in complex with guide RNA and target DNA.Nishimasu, H., Ran FA, Hsu PD, Konermann S., Shehata SI, Dohmae N., Ishitani R., Zhang F., and Nureki O. Cell, 2014/02/27, Volume 156, Issue 5, p.935-49, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
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Genome editing using cas9 nickases.Trevino, AE, and Zhang F. Methods in enzymology, 2014/01/01, Volume 546, p.161-74, (2014) Read More / View Supplemental Materials
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RNA-Guided Genome Editing of Mammalian Cells.Pyzocha, NK, Ran FA, Hsu PD, and Zhang F. Methods in molecular biology (Clifton, N.J.), 2014/01/01, Volume 1114, p.269-77, (2014) Read More / View Supplemental Materials
Abstract
2013
Genome engineering using the CRISPR-Cas9 system.Ran, FA, Hsu PD, Wright J., Agarwala V., Scott DA, and Zhang F. Nature protocols, 2013/11/01, Volume 8, Issue 11, p.2281-308, (2013) Read More / View Supplemental Materials
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Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity.Ran, FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S., Trevino AE, Scott DA, Inoue A., Matoba S., Zhang Y., and Zhang F. Cell, 2013/09/12, Volume 154, Issue 6, p.1380-9, (2013) Read More / View Supplemental Materials
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Optical control of mammalian endogenous transcription and epigenetic states.Konermann, S., Brigham MD, Trevino AE, Hsu PD, Heidenreich M., Cong L., Platt RJ, Scott DA, Church GM, and Zhang F. Nature, 2013/08/22, Volume 500, Issue 7463, p.472-6, (2013) Read More / View Supplemental Materials
Abstract
DNA targeting specificity of RNA-guided Cas9 nucleases.Hsu, PD, Scott DA, Weinstein JA, Ran FA, Konermann S., Agarwala V., Li Y., Fine EJ, Wu X., Shalem O., Cradick TJ, Marraffini LA, Bao G., and Zhang F. Nature biotechnology, 2013/07/21, (2013) Read More / View Supplemental Materials
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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.Bikard, D., Jiang W., Samai P., Hochschild A., Zhang F., and Marraffini LA Nucleic acids research, 2013/06/12, (2013) Read More / View Supplemental Materials
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Multiplex Genome Engineering Using CRISPR/Cas Systems.Cong, L., Ran FA, Cox D., Lin S., Barretto R., Habib N., Hsu PD, Wu X., Jiang W., Marraffini LA, and Zhang F. Science (New York, N.Y.), 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
2012
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains.Cong, L., Zhou R., Kuo YC, Cunniff M., and Zhang F. Nature communications, 2012/07/24, Volume 3, p.968, (2012) Read More / View Supplemental Materials
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Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers.Briggs, AW, Rios X., Chari R., Yang L., Zhang F., Mali P., and Church GM Nucleic acids research, 2012/06/26, (2012) Read More / View Supplemental Materials
Abstract
A transcription activator-like effector toolbox for genome engineering.Sanjana, NE, Cong L., Zhou Y., Cunniff MM, Feng G., and Zhang F. Nature protocols, 2012/01/05, Volume 7, Issue 1, p.171-92, (2012) Read More / View Supplemental Materials
Abstract
2011
The microbial opsin family of optogenetic tools.Zhang, F., Vierock J., Yizhar O., Fenno LE, Tsunoda S., Kianianmomeni A., Prigge M., Berndt A., Cushman J., Polle J., Magnuson J., Hegemann P., and Deisseroth K. Cell, 2011/12/23, Volume 147, Issue 7, p.1446-57, (2011) Read More / View Supplemental Materials
Abstract
  • Showing 1-55 of 55 Results