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  • Showing 1-23 of 23 Results
2015
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.Lenz, TL, Deutsch AJ, Han B., Hu X., Okada Y., Eyre S., Knapp M., Zhernakova A., Huizinga TW, Abecasis G., Becker J., Boeckxstaens GE, Chen WM, Franke A., Gladman DD, Gockel I., Gutierrez-Achury J., Martin J., Nair RP, Nöthen MM, et al. Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Hu, X., Deutsch AJ, Lenz TL, Onengut-Gumuscu S., Han B., Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, and Raychaudhuri S. Nature genetics, 2015/07/13, (2015) Read More / View Supplemental Materials
Abstract
Directional dominance on stature and cognition in diverse human populations.Joshi, PK, Esko T., Mattsson H., Eklund N., Gandin I., Nutile T., Jackson AU, Schurmann C., Smith AV, Zhang W., Okada Y., Stančáková A., Faul JD, Zhao W., Bartz TM, Concas MP, Franceschini N., Enroth S., Vitart V., Trompet S., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Association of a 62 Variant Type 2 Diabetes Genetic Risk Score with Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.Dauriz, M., Porneala BC, Guo X., Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E., Bowden DW, Florez JC, Fornage M., Hivert MF, Jacobs DR Jr, Kabagambe EK, Lewis CE, Murabito JM, Rasmussen-Torvik LJ, Rich SS, Vassy JL, et al. Circulation. Cardiovascular genetics, 2015/03/24, (2015) Read More / View Supplemental Materials
Abstract
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Onengut-Gumuscu, S., Chen WM, Burren O., Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E., Bonnie JK, Szpak M., Schofield E., Achuthan P., Guo H., Fortune MD, Stevens H., Walker NM, Ward LD, Kundaje A., Kellis M., Daly M. J., Barrett JC, et al. Nature genetics, 2015/03/09, (2015) Read More / View Supplemental Materials
Abstract
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Wessel, J., Chu AY, Willems SM, Wang S., Yaghootkar H., Brody JA, Dauriz M., Hivert MF, Raghavan S., Lipovich L., Hidalgo B., Fox K., Huffman JE, An P., Lu Y., Rasmussen-Torvik LJ, Grarup N., Ehm MG, Li L., Baldridge AS, et al. Nature communications, 2015/01/29, Volume 6, p.5897, (2015) Read More / View Supplemental Materials
Abstract
Exome Sequencing in Suspected Monogenic Dyslipidemias.Stitziel, NO, Peloso GM, Abifadel M., Cefalù AB, Fouchier S., Motazacker MM, Tada H., Larach DB, Awan Z., Haller JF, Pullinger CR, Varret M., Rabès JP, Noto D., Tarugi P., Kawashiri MA, Nohara A., Yamagishi M., Risman M., Deo R., et al. Circulation. Cardiovascular genetics, 2015/01/27, (2015) Read More / View Supplemental Materials
Abstract
2014
Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.Palmer, ND, Goodarzi MO, Langefeld CD, Wang N., Guo X., Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, Haritunians T., Ziegler JT, Williams AH, Stefansovski D., Cui J., Mackay AW, Henkin LF, Bergman RN, Gao X., Gauderman J., et al. Diabetes, 2014/12/18, (2014) Read More / View Supplemental Materials
Abstract
Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans.Naik, RP, Derebail VK, Grams ME, Franceschini N., Auer PL, Peloso GM, Young BA, Lettre G., Peralta CA, Katz R., Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P., Rich SS, Smith JD, Boerwinkle E., Rosamond WD, Ito K., et al. JAMA, 2014/11/26, Volume 312, Issue 20, p.2115-2125, (2014) Read More / View Supplemental Materials
Abstract
Association of exome sequences with plasma C-reactive protein levels in >9000 participants.Schick, UM, Auer PL, Bis JC, Lin H., Wei P., Pankratz N., Lange LA, Brody J., Stitziel NO, Kim DS, Carlson CS, Fornage M., Haessler J., Hsu L., Jackson RD, Kooperberg C., Leal SM, Psaty BM, Boerwinkle E., Tracy R., et al. Human molecular genetics, 2014/09/03, (2014) Read More / View Supplemental Materials
Abstract
Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.Du, M., Auer PL, Jiao S., Haessler J., Altshuler D., Boerwinkle E., Carlson CS, Carty CL, Chen YD, Curtis K., Franceschini N., Hsu L., Jackson R., Lange LA, Lettre G., Monda KL, and National Heart, Lung Blood Institute(NHLBI) GO Exome Sequencing Project, Nickerson DA, Reiner AP, Rich SS, et al. Human molecular genetics, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.and TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung Blood Institute, Crosby J., Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y., Tang ZZ, Zhang H., Hindy G., Masca N., Stirrups K., Kanoni S., Do R., Jun G., Hu Y., Kang HM, Xue C., Goel A., et al. The New England journal of medicine, 2014/07/03, Volume 371, Issue 1, p.22-31, (2014) Read More / View Supplemental Materials
Abstract
Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells.Hu, X., Im HK, Raj T., Brennan PJ, Trynka G., Teslovich N., Slowikowski K., Chen WM, Onengut S., Baecher-Allan C., De Jager PL, Rich SS, Stranger BE, Brenner MB, and Raychaudhuri S. PLoS genetics, 2014/06/01, Volume 10, Issue 6, p.e1004404, (2014) Read More / View Supplemental Materials
Abstract
A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups.Weng, LC, Tang W., Rich SS, Smith NL, Redline S., O'Donnell CJ, Basu S., Reiner AP, Delaney JA, Tracy RP, Palmer CD, Young T., Yang Q., Folsom AR, and Cushman M. Thrombosis research, 2014/05/20, (2014) Read More / View Supplemental Materials
Abstract
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.Peloso, GM, Auer PL, Bis JC, Voorman A., Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M., Isaacs A., Jakobsdottir J., Feitosa MF, Davies G., Huffman JE, Manichaikul A., Davis B., Lohman K., Joon AY, Smith AV, et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.223-32, (2014) Read More / View Supplemental Materials
Abstract
Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.Lange, LA, Hu Y., Zhang H., Xue C., Schmidt EM, Tang ZZ, Bizon C., Lange EM, Smith JD, Turner EH, Jun G., Kang HM, Peloso G., Auer P., Li KP, Flannick J., Zhang J., Fuchsberger C., Gaulton K., Lindgren C., et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.233-45, (2014) Read More / View Supplemental Materials
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2013
Common variants associated with plasma triglycerides and risk for coronary artery disease.Do, R., Willer CJ, Schmidt EM, Sengupta S., Gao C., Peloso GM, Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich ML, Mora S., Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A., Den Hertog HM, Donnelly LA, Ehret GB, Esko T., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1345-52, (2013) Read More / View Supplemental Materials
Abstract
Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes.Meschia, JF, Arnett DK, Ay H., Brown RD Jr, Benavente OR, Cole JW, de Bakker PI, Dichgans M., Doheny KF, Fornage M., Grewal RP, Gwinn K., Jern C., Conde JJ, Johnson JA, Jood K., Laurie CC, Lee JM, Lindgren A., Markus HS, et al. Stroke; a journal of cerebral circulation, 2013/10/01, Volume 44, Issue 10, p.2694-702, (2013) Read More / View Supplemental Materials
Abstract
2012
Autoimmunity: insights from human genomics.Raychaudhuri, S., and Rich SS Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.513-5, (2012) Read More / View Supplemental Materials
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci.Saxena, R., Elbers CC, Guo Y., Peter I., Gaunt TR, Mega JL, Lanktree MB, Tare A., Castillo BA, Li YR, Johnson T., Bruinenberg M., Gilbert-Diamond D., Rajagopalan R., Voight BF, Balasubramanyam A., Barnard J., Bauer F., Baumert J., Bhangale T., et al. American journal of human genetics, 2012/03/09, Volume 90, Issue 3, p.410-425, (2012) Read More / View Supplemental Materials
Abstract
Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project.Musunuru, K., Romaine SP, Lettre G., Wilson JG, Volcik KA, Tsai MY, Taylor HA Jr, Schreiner PJ, Rotter JI, Rich SS, Redline S., Psaty BM, Papanicolaou GJ, Ordovas JM, Liu K., Krauss RM, Glazer NL, Gabriel SB, Fornage M., Cupples LA, et al. PloS one, 2012/01/01, Volume 7, Issue 5, p.e36473, (2012) Read More / View Supplemental Materials
Abstract
2011
Genome-wide Association of Copy-Number Variation Reveals an Association between Short Stature and the Presence of Low-Frequency Genomic Deletions.Dauber, A., Yu Y., Turchin MC, Chiang CW, Meng YA, Demerath EW, Patel SR, Rich SS, Rotter JI, Schreiner PJ, Wilson JG, Shen Y., Wu BL, and Hirschhorn JN American journal of human genetics, 2011/12/09, Volume 89, Issue 6, p.751-9, (2011) Read More / View Supplemental Materials
Abstract
2010
Candidate gene association resource (CARe): design, methods, and proof of concept.Musunuru, K., Lettre G., Young T., Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q., Chen MH, Lapchyk N., Crenshaw A., Ziaugra L., Rachupka A., Benjamin EJ, Cupples LA, Fornage M., Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C., et al. Circulation. Cardiovascular genetics, 2010/06/01, Volume 3, Issue 3, p.267-75, (2010) Read More / View Supplemental Materials
Abstract
  • Showing 1-23 of 23 Results