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2016
Relation of genomic variants for Alzheimer disease dementia to common neuropathologies.Farfel, JM, Yu L., Buchman AS, Schneider JA, De Jager PL, and Bennett DA Neurology, 2016/07/01, (2016) Read More / View Supplemental Materials
Abstract
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.Matteini, AM, Tanaka T., Karasik D., Atzmon G., Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G., Evans DS, Holtfreter B., Lohman K., Lunetta KL, Mangino M., Smith AV, Smith JA, Teumer A., Yu L., Arking DE, et al. Aging cell, 2016/06/21, (2016) Read More / View Supplemental Materials
Abstract
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.Ali, YO, Allen HM, Yu L., Li-Kroeger D., Bakhshizadehmahmoudi D., Hatcher A., McCabe C., Xu J., Bjorklund N., Taglialatela G., Bennett DA, De Jager PL, Shulman JM, Bellen HJ, and Lu HC PLoS biology, 2016/06/01, Volume 14, Issue 6, p.e1002472, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association study identifies 74 loci associated with educational attainment.Okbay, A., Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P., Chen GB, Emilsson V., Meddens SF, Oskarsson S., Pickrell JK, Thom K., Timshel P., de Vlaming R., Abdellaoui A., Ahluwalia TS, Bacelis J., Baumbach C., Bjornsdottir G., et al. Nature, 2016/05/11, Volume 533, Issue 7604, p.539-42, (2016) Read More / View Supplemental Materials
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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.Okbay, A., Baselmans BM, De Neve JE, Turley P., Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J., Gratten J., Lee JJ, Liu JZ, de Vlaming R., Ahluwalia TS, Buchwald J., Cavadino A., Frazier-Wood AC, Furlotte NA, Garfield V., et al. Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.Allen, GI, Amoroso N., Anghel C., Balagurusamy V., Bare CJ, Beaton D., Bellotti R., Bennett DA, Boehme K., Boutros PC, Caberlotto L., Caloian C., Campbell F., Neto EC, Chang YC, Chen B., Chen CY, Chien TY, Clark T., Das S., et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/04/11, (2016) Read More / View Supplemental Materials
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Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.Roostaei, T., Nazeri A., Felsky D., De Jager PL, Schneider JA, Pollock BG, Bennett DA, Voineskos AN, and Alzheimer’s Disease Neuroimaging Initiative(ADNI) Molecular psychiatry, 2016/03/29, (2016) Read More / View Supplemental Materials
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Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology.Yu, L., Chibnik L., Yang J., McCabe C., Xu J., Schneider JA, De Jager PL, and Bennett DA Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/03/23, (2016) Read More / View Supplemental Materials
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Lu, Y., Day FR, Gustafsson S., Buchkovich ML, Na J., Bataille V., Cousminer DL, Dastani Z., Drong AW, Esko T., Evans DM, Falchi M., Feitosa MF, Ferreira T., Hedman Å. K., Haring R., Hysi PG, Iles MM, Justice AE, Kanoni S., et al. Nature communications, 2016/02/01, Volume 7, p.10495, (2016) Read More / View Supplemental Materials
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Higher brain BDNF gene expression is associated with slower cognitive decline in older adults.Buchman, AS, Yu L., Boyle PA, Schneider JA, De Jager PL, and Bennett DA Neurology, 2016/01/27, (2016) Read More / View Supplemental Materials
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Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.Felsky, D., De Jager PL, Schneider JA, Arfanakis K., Fleischman DA, Arvanitakis Z., Honer WG, Pouget JG, Mizrahi R., Pollock BG, Kennedy JL, Bennett DA, Voineskos AN, and authors of the Alzheimer’s Disease Neuroimaging Initiative Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016/01/13, (2016) Read More / View Supplemental Materials
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2015
Common Variants in DRD2 are Associated with Sleep Duration: The CARe Consortium.Cade, BE, Gottlieb DJ, Lauderdale DS, Bennett DA, Buchman AS, Buxbaum SG, De Jager PL, Evans DS, Fülöp T., Gharib SA, Johnson WC, Im HK, Larkin EK, Lee SK, Lim AS, Punjabi NM, Shin C., Stone KL, Tranah GJ, Weng J., et al. Human molecular genetics, 2015/10/13, (2015) Read More / View Supplemental Materials
Abstract
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.Winkler, TW, Justice AE, Graff M., Barata L., Feitosa MF, Chu S., Czajkowski J., Esko T., Fall T., Kilpeläinen TO, Lu Y., Mägi R., Mihailov E., Pers TH, Rüeger S., Teumer A., Ehret GB, Ferreira T., Heard-Costa NL, Karjalainen J., et al. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005378, (2015) Read More / View Supplemental Materials
Abstract
Association of APOE with tau-tangle pathology with and without β-amyloid.Farfel, JM, Yu L., De Jager PL, Schneider JA, and Bennett DA Neurobiology of aging, 2015/09/28, (2015) Read More / View Supplemental Materials
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CD33 modulates TREM2: convergence of Alzheimer loci.Chan, G., White CC, Winn PA, Cimpean M., Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, and De Jager PL Nature neuroscience, 2015/09/28, (2015) Read More / View Supplemental Materials
Abstract
Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.Ghani, M., Reitz C., Cheng R., Vardarajan BN, Jun G., Sato C., Naj A., Rajbhandary R., Wang LS, Valladares O., Lin CF, Larson EB, Graff-Radford NR, Evans D., De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T., Ertekin-Taner N., et al. JAMA neurology, 2015/09/14, (2015) Read More / View Supplemental Materials
Abstract
APOE and cerebral amyloid angiopathy in community-dwelling older persons.Yu, L., Boyle PA, Nag S., Leurgans S., Buchman AS, Wilson RS, Arvanitakis Z., Farfel JM, De Jager PL, Bennett DA, and Schneider JA Neurobiology of aging, 2015/08/15, (2015) Read More / View Supplemental Materials
Abstract
GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Ramanan, VK, Risacher SL, Nho K., Kim S., Shen L., McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S., Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, et al. Brain : a journal of neurology, 2015/08/11, (2015) Read More / View Supplemental Materials
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Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.Hohman, TJ, Cooke-Bailey JN, Reitz C., Jun G., Naj A., Beecham GW, Liu Z., Carney RM, Vance JM, Cuccaro ML, Rajbhandary R., Vardarajan BN, Wang LS, Valladares O., Lin CF, Larson EB, Graff-Radford NR, Evans D., De Jager PL, Crane PK, et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2015/06/16, (2015) Read More / View Supplemental Materials
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Alzheimer's loci: epigenetic associations and interaction with genetic factors.Chibnik, LB, Yu L., Eaton ML, Srivastava G., Schneider JA, Kellis M., Bennett DA, and De Jager PL Annals of clinical and translational neurology, 2015/06/01, Volume 2, Issue 6, p.636-47, (2015) Read More / View Supplemental Materials
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Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies.Yang, J., Yu L., Gaiteri C., Srivastava GP, Chibnik LB, Leurgans SE, Schneider JA, Meissner A., De Jager PL, and Bennett DA The international journal of biochemistry & cell biology, 2015/05/21, (2015) Read More / View Supplemental Materials
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A novel Alzheimer disease locus located near the gene encoding tau protein.Jun, G., Ibrahim-Verbaas CA, Vronskaya M., Lambert JC, Chung J., Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C., Harold D., Lunetta KL, Destefano AL, Grenier-Boley B., Sims R., Beecham GW, Smith AV, Chouraki V., Hamilton-Nelson KL, Ikram MA, et al. Molecular psychiatry, 2015/03/17, (2015) Read More / View Supplemental Materials
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The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Yu, L., De Jager PL, Yang J., Trojanowski JQ, Bennett DA, and Schneider JA Neurology, 2015/02/04, (2015) Read More / View Supplemental Materials
Abstract
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949).Davies, G., Armstrong N., Bis JC, Bressler J., Chouraki V., Giddaluru S., Hofer E., Ibrahim-Verbaas CA, Kirin M., Lahti J., van der Lee SJ, Le Hellard S., Liu T., Marioni RE, Oldmeadow C., Postmus I., Smith AV, Smith JA, Thalamuthu A., Thomson R., et al. Molecular psychiatry, 2015/02/03, (2015) Read More / View Supplemental Materials
Abstract
2014
Title (78 characters): A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.Replogle, JM, Chan G., White CC, Raj T., Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, and De Jager PL Annals of neurology, 2014/12/26, (2014) Read More / View Supplemental Materials
Abstract
FASTKD2 is associated with memory and hippocampal structure in older adults.Ramanan, VK, Nho K., Shen L., Risacher SL, Kim S., McDonald BC, Farlow MR, Foroud TM, Gao S., Soininen H., Kłoszewska I., Mecocci P., Tsolaki M., Vellas B., Lovestone S., Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, et al. Molecular psychiatry, 2014/11/11, (2014) Read More / View Supplemental Materials
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Association of Brain DNA Methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 With Pathological Diagnosis of Alzheimer Disease.Yu, L., Chibnik LB, Srivastava GP, Pochet N., Yang J., Xu J., Kozubek J., Obholzer N., Leurgans SE, Schneider JA, Meissner A., De Jager PL, and Bennett DA JAMA neurology, 2014/11/03, (2014) Read More / View Supplemental Materials
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24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex.Lim, AS, Srivastava GP, Yu L., Chibnik LB, Xu J., Buchman AS, Schneider JA, Myers AJ, Bennett DA, and De Jager PL PLoS genetics, 2014/11/01, Volume 10, Issue 11, p.e1004792, (2014) Read More / View Supplemental Materials
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Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study.Naj, AC, Jun G., Reitz C., Kunkle BW, Perry W., Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E., Barmada MM, et al. JAMA neurology, 2014/09/08, (2014) Read More / View Supplemental Materials
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GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.Broer, L., Buchman AS, Deelen J., Evans DS, Faul JD, Lunetta KL, Sebastiani P., Smith JA, Smith AV, Tanaka T., Yu L., Arnold AM, Aspelund T., Benjamin EJ, De Jager PL, Eirkisdottir G., Evans DA, Garcia ME, Hofman A., Kaplan RC, et al. The journals of gerontology. Series A, Biological sciences and medical sciences, 2014/09/08, (2014) Read More / View Supplemental Materials
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.De Jager, PL, Srivastava G., Lunnon K., Burgess J., Schalkwyk LC, Yu L., Eaton ML, Keenan BT, Ernst J., McCabe C., Tang A., Raj T., Replogle J., Brodeur W., Gabriel S., Chai HS, Younkin C., Younkin SG, Zou F., Szyf M., et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1156-1163, (2014) Read More / View Supplemental Materials
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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.Lunnon, K., Smith R., Hannon E., De Jager PL, Srivastava G., Volta M., Troakes C., Al-Sarraj S., Burrage J., Macdonald R., Condliffe D., Harries LW, Katsel P., Haroutunian V., Kaminsky Z., Joachim C., Powell J., Lovestone S., Bennett DA, Schalkwyk LC, et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1164-1170, (2014) Read More / View Supplemental Materials
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Epigenomics of Alzheimer's disease.Bennett, DA, Yu L., Yang J., Srivastava GP, Aubin C., and De Jager PL Translational research : the journal of laboratory and clinical medicine, 2014/05/16, (2014) Read More / View Supplemental Materials
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Life Extension Factor Klotho Enhances Cognition.Dubal, DB, Yokoyama JS, Zhu L., Broestl L., Worden K., Wang D., Sturm VE, Kim D., Klein E., Yu GQ, Ho K., Eilertson KE, Yu L., Kuro-O M., De Jager PL, Coppola G., Small GW, Bennett DA, Kramer JH, Abraham CR, et al. Cell reports, 2014/05/07, (2014) Read More / View Supplemental Materials
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Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease.Bennett, DA, Yu L., and De Jager PL Biochemical pharmacology, 2014/02/06, (2014) Read More / View Supplemental Materials
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Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.Escott-Price, V., Bellenguez C., Wang LS, Choi SH, Harold D., Jones L., Holmans P., Gerrish A., Vedernikov A., Richards A., Destefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R., Jun G., Bis JC, Beecham GW, Grenier-Boley B., Russo G., et al. PloS one, 2014/01/01, Volume 9, Issue 6, p.e94661, (2014) Read More / View Supplemental Materials
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2013
Charting a dynamic DNA methylation landscape of the human genome.Ziller, MJ, Gu H., Müller F., Donaghey J., Tsai LT, Kohlbacher O., De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A., and Meissner A. Nature, 2013/08/22, Volume 500, Issue 7463, p.477-81, (2013) Read More / View Supplemental Materials
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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.Bradshaw, EM, Chibnik LB, Keenan BT, Ottoboni L., Raj T., Tang A., Rosenkrantz LL, Imboywa S., Lee M., Von Korff A., Alzheimer Disease Neuroimaging Initiative, Morris MC, Evans DA, Johnson K., Sperling RA, Schneider JA, Bennett DA, and De Jager PL Nature neuroscience, 2013/07/01, Volume 16, Issue 7, p.848-50, (2013) Read More / View Supplemental Materials
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Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues.Zhu, J., Adli M., Zou JY, Verstappen G., Coyne M., Zhang X., Durham T., Miri M., Deshpande V., De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R., Cowan CA, Meissner A., Epstein CB, Shoresh N., and Bernstein BE Cell, 2013/01/31, Volume 152, Issue 3, p.642-54, (2013) Read More / View Supplemental Materials
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2012
Alzheimer Disease Susceptibility Loci: Evidence for a Protein Network under Natural Selection.Raj, T., Shulman JM, Keenan BT, Chibnik LB, Evans DA, Bennett DA, Stranger BE, and De Jager PL American journal of human genetics, 2012/04/06, Volume 90, Issue 4, p.720-6, (2012) Read More / View Supplemental Materials
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Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.Biffi, A., Shulman JM, Jagiella JM, Cortellini L., Ayres AM, Schwab K., Brown DL, Silliman SL, Selim M., Worrall BB, Meschia JF, Slowik A., De Jager PL, Greenberg SM, Schneider JA, Bennett DA, and Rosand J. Neurology, 2012/01/18, (2012) Read More / View Supplemental Materials
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2011
The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease.Yu, L., Shulman JM, Chibnik L., Leurgans S., Schneider JA, De Jager PL, and Bennett DA Aging cell, 2011/11/28, (2011) Read More / View Supplemental Materials
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A genome-wide scan for common variants affecting the rate of age-related cognitive decline.De Jager, PL, Shulman JM, Chibnik LB, Keenan BT, Raj T., Wilson RS, Yu L., Leurgans SE, Tran D., Aubin C., Anderson CD, Biffi A., Corneveaux JJ, Huentelman MJ, Alzheimer's Disease Neuroimaging Initiative, Rosand J., Daly M. J., Myers AJ, Reiman EM, Bennett DA, et al. Neurobiology of aging, 2011/11/03, (2011) Read More / View Supplemental Materials
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  • Showing 1-43 of 43 Results