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2016
Integrated genetic and pharmacologic interrogation of rare cancers.Hong, AL, Tseng YY, Cowley GS, Jonas O., Cheah JH, Kynnap BD, Doshi MB, Oh C., Meyer SC, Church AJ, Gill S., Bielski CM, Keskula P., Imamovic A., Howell S., Kryukov GV, Clemons PA, Tsherniak A., Vazquez F., Crompton BD, et al. Nature communications, 2016/06/22, Volume 7, p.11987, (2016) Read More / View Supplemental Materials
Abstract
Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting.Aguirre, AJ, Meyers RM, Weir BA, Vazquez F., Zhang CZ, Ben-David U., Cook A., Ha G., Harrington WF, Doshi MB, Kost-Alimova M., Gill S., Xu H., Ali LD, Jiang G., Pantel S., Lee Y., Goodale A., Cherniack AD, Oh C., et al. Cancer discovery, 2016/06/03, (2016) Read More / View Supplemental Materials
Abstract
2015
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.Kim, KH, Kim W., Howard TP, Vazquez F., Tsherniak A., Wu JN, Wang W., Haswell JR, Walensky LD, Hahn WC, Orkin SH, and Roberts CW Nature medicine, 2015/11/09, (2015) Read More / View Supplemental Materials
Abstract
2014
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.Perry, JA, Kiezun A., Tonzi P., Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E., Pedamallu CS, Helman E., Taylor-Weiner A., McKenna A., Deluca DS, Lawrence MS, Ambrogio L., Sougnez C., Sivachenko A., Walensky LD, Wagle N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences.Pugh, TJ, Yu W., Yang J., Field AL, Ambrogio L., Carter SL, Cibulskis K., Giannikopoulos P., Kiezun A., Kim J., McKenna A., Nickerson E., Getz G., Hoffher S., Messinger YH, Dehner LP, Roberts CW, Rodriguez-Galindo C., Williams GM, Rossi CT, et al. Oncogene, 2014/06/09, (2014) Read More / View Supplemental Materials
Abstract
ARID1B is a specific vulnerability in ARID1A-mutant cancers.Helming, KC, Wang X., Wilson BG, Vazquez F., Haswell JR, Manchester HE, Kim Y., Kryukov GV, Ghandi M., Aguirre AJ, Jagani Z., Wang Z., Garraway LA, Hahn WC, and Roberts CW Nature medicine, 2014/03/01, Volume 20, Issue 3, p.251-4, (2014) Read More / View Supplemental Materials
Abstract
Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation.Wilson, BG, Helming KC, Wang X., Kim Y., Vazquez F., Jagani Z., Hahn WC, and Roberts CW Molecular and cellular biology, 2014/03/01, Volume 34, Issue 6, p.1136-44, (2014) Read More / View Supplemental Materials
Abstract
2013
Mutational heterogeneity in cancer and the search for new cancer-associated genes.Lawrence, MS, Stojanov P., Polak P., Kryukov GV, Cibulskis K., Sivachenko A., Carter SL, Stewart C., Mermel CH, Roberts SA, Kiezun A., Hammerman PS, McKenna A., Drier Y., Zou L., Ramos AH, Pugh TJ, Stransky N., Helman E., Kim J., et al. Nature, 2013/07/11, Volume 499, Issue 7457, p.214-8, (2013) Read More / View Supplemental Materials
Abstract
2012
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.Lee, RS, Stewart C., Carter SL, Ambrogio L., Cibulskis K., Sougnez C., Lawrence MS, Auclair D., Mora J., Golub T. R., Biegel JA, Getz G., and Roberts CW The Journal of clinical investigation, 2012/07/16, (2012) Read More / View Supplemental Materials
Abstract
2007
Metagene projection for cross-platform, cross-species characterization of global transcriptional states.Tamayo, P., Scanfeld D., Ebert BL, Gillette MA, Roberts CW, and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2007/04/03, Volume 104, Issue 14, p.5959-64, (2007) Read More / View Supplemental Materials
Abstract
  • Showing 1-10 of 10 Results