Scientific Publications

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.Graham, RR, Kyogoku C., Sigurdsson S., Vlasova IA, Davies LR, Baechler EC, Plenge RM, Koeuth T., Ortmann WA, Hom G., Bauer JW, Gillett C., Burtt N., Cunninghame Graham DS, Onofrio R., Petri M., Gunnarsson I., Svenungsson E., Rönnblom L., Nordmark G., et al. Proceedings of the National Academy of Sciences of the United States of America, 2007/04/17, Volume 104, Issue 16, p.6758-63, (2007) Read More / View Supplemental Materials

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Abstract

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.Graham, RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW, Ortmann WA, Koeuth T., González Escribano MF, Argentine and Spanish Collaborative Groups, Pons-Estel B., Petri M., Daly M., Gregersen PK, Martín J., Altshuler D., Behrens TW, and Alarcón-Riquelme ME Nature genetics, 2006/05/01, Volume 38, Issue 5, p.550-5, (2006) Read More / View Supplemental Materials

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Abstract