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2016
Gene expression elucidates functional impact of polygenic risk for schizophrenia.Fromer, M., Roussos P., Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A., Shah HR, Klei LL, Kramer R., Pinto D., Gümüş ZH, Cicek AE, Dang KK, Browne A., Lu C., Xie L., Readhead B., et al. Nature neuroscience, 2016/09/26, (2016) Read More / View Supplemental Materials
Abstract
Analysis of protein-coding genetic variation in 60,706 humans.Lek, M., Karczewski KJ, Minikel EV, Samocha KE, Banks E., Fennell T., O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T., Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K., Zhao F., Zou J., Pierce-Hoffman E., Berghout J., Cooper DN, et al. Nature, 2016/08/17, Volume 536, Issue 7616, p.285-91, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia.Legge, SE, Hamshere ML, Ripke S., Pardinas AF, Goldstein JI, Rees E., Richards AL, Leonenko G., Jorskog LF, Clozapine-Induced Agranulocytosis Consortium, Chambert KD, Collier DA, Genovese G., Giegling I., Holmans P., Jonasdottir A., Kirov G., McCarroll SA, MacCabe JH, Mantripragada K., et al. Molecular psychiatry, 2016/07/12, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.Power, RA, Tansey KE, Buttenschøn HN, Cohen-Woods S., Bigdeli T., Hall LS, Kutalik Z., Lee SH, Ripke S., Steinberg S., Teumer A., Viktorin A., Wray NR, Arolt V., Baune BT, Boomsma DI, Børglum AD, Byrne EM, Castelao E., Craddock N., et al. Biological psychiatry, 2016/05/24, (2016) Read More / View Supplemental Materials
Abstract
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.Ruderfer, DM, Charney AW, Readhead B., Kidd BA, Kähler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, and Sklar P. The lancet. Psychiatry, 2016/04/01, Volume 3, Issue 4, p.350-7, (2016) Read More / View Supplemental Materials
Abstract
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.Singh, T., Kurki MI, Curtis D., Purcell SM, Crooks L., McRae J., Suvisaari J., Chheda H., Blackwood D., Breen G., Pietiläinen O., Gerety SS, Ayub M., Blyth M., Cole T., Collier D., Coomber EL, Craddock N., Daly M. J., Danesh J., et al. Nature neuroscience, 2016/04/01, Volume 19, Issue 4, p.571-7, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.Pers, TH, Timshel P., Ripke S., Lent S., Sullivan PF, O'Donovan MC, Franke L., Hirschhorn JN, and Schizophrenia Working Group of the Psychiatric Genomics Consortium Human molecular genetics, 2016/03/15, Volume 25, Issue 6, p.1247-54, (2016) Read More / View Supplemental Materials
Abstract
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.Franke, B., Stein JL, Ripke S., Anttila V., Hibar DP, van Hulzen KJ, Arias-Vasquez A., Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P., McMahon FJ, Meyer-Lindenberg A., Mattheisen M., Andreassen OA, Gruber O., Sachdev PS, Roiz-Santiañez R., Saykin AJ, et al. Nature neuroscience, 2016/03/01, Volume 19, Issue 3, p.420-31, (2016) Read More / View Supplemental Materials
Abstract
Integrative approaches for large-scale transcriptome-wide association studies.Gusev, A., Ko A., Shi H., Bhatia G., Chung W., Penninx BW, Jansen R., de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E., Alvarez M., Civelek M., Lusis AJ, Lehtimäki T., Raitoharju E., Kähönen M., Seppälä I., Raitakari OT, et al. Nature genetics, 2016/02/08, (2016) Read More / View Supplemental Materials
Abstract
Quantifying prion disease penetrance using large population control cohorts.Minikel, EV, Vallabh SM, Lek M., Estrada K., Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LP, Gambetti P., Blevins J., Zhang S., Cohen Y., Chen W., Yamada M., Hamaguchi T., Sanjo N., Mizusawa H., Nakamura Y., Kitamoto T., et al. Science translational medicine, 2016/01/20, Volume 8, Issue 322, p.322ra9, (2016) Read More / View Supplemental Materials
Abstract
2015
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.McClay, JL, Shabalin AA, Dozmorov MG, Adkins DE, Kumar G., Nerella S., Clark SL, Bergen SE, Swedish Schizophrenia Consortium, Hultman CM, Magnusson PK, Sullivan PF, Aberg KA, and van den Oord EJ Genome biology, 2015/12/23, Volume 16, Issue 1, p.291, (2015) Read More / View Supplemental Materials
Abstract
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.Sellgren, CM, Kegel ME, Bergen SE, Ekman CJ, Olsson S., Larsson M., Vawter MP, Backlund L., Sullivan PF, Sklar P., Smoller JW, Magnusson PK, Hultman CM, Walther-Jallow L., Svensson CI, Lichtenstein P., Schalling M., Engberg G., Erhardt S., and Landén M. Molecular psychiatry, 2015/12/15, (2015) Read More / View Supplemental Materials
Abstract
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.Lee, SH, Byrne EM, Hultman CM, Kähler A., Vinkhuyzen AA, Ripke S., Andreassen OA, Frisell T., Gusev A., Hu X., Karlsson R., Mantzioris VX, McGrath JJ, Mehta D., Stahl EA, Zhao Q., Kendler KS, Sullivan PF, Price AL, O'Donovan M., et al. International journal of epidemiology, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.Clark, SL, Aberg KA, Nerella S., Kumar G., McClay JL, Chen W., Xie LY, Harada A., Shabalin AA, Gao G., Bergen SE, Hultman CM, Magnusson PK, Sullivan PF, and van den Oord EJ Alcoholism, clinical and experimental research, 2015/07/04, (2015) Read More / View Supplemental Materials
Abstract
Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.Agerbo, E., Sullivan PF, Vilhjálmsson BJ, Pedersen CB, Mors O., Børglum AD, Hougaard DM, Hollegaard MV, Meier S., Mattheisen M., Ripke S., Wray NR, and Mortensen PB JAMA psychiatry, 2015/04/01, (2015) Read More / View Supplemental Materials
Abstract
2014
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence.Genovese, G., Kähler AK, Handsaker RE, Lindberg J., Rose SA, Bakhoum SF, Chambert K., Mick E., Neale BM, Fromer M., Purcell SM, Svantesson O., Landén M., Höglund M., Lehmann S., Gabriel SB, Moran JL, Lander E. S., Sullivan PF, Sklar P., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
Abstract
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.Gusev, A., Lee SH, Trynka G., Finucane H., Vilhjálmsson BJ, Xu H., Zang C., Ripke S., Bulik-Sullivan B., Stahl E., Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M., Pasaniuc B., Sullivan PF, Neale BM, et al. American journal of human genetics, 2014/11/06, Volume 95, Issue 5, p.535-52, (2014) Read More / View Supplemental Materials
Abstract
No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia.Ruderfer, DM, Lim ET, Genovese G., Moran JL, Hultman CM, Sullivan PF, McCarroll SA, Holmans P., Sklar P., and Purcell SM European journal of human genetics : EJHG, 2014/11/05, (2014) Read More / View Supplemental Materials
Abstract
Genetic Studies of Major Depressive Disorder: Why Are There No Genome-wide Association Study Findings and What Can We Do About It?Levinson, DF, Mostafavi S., Milaneschi Y., Rivera M., Ripke S., Wray NR, and Sullivan PF Biological psychiatry, 2014/10/01, Volume 76, Issue 7, p.510-2, (2014) Read More / View Supplemental Materials
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Goldstein, JI, Fredrik Jarskog L., Hilliard C., Alfirevic A., Duncan L., Fourches D., Huang H., Lek M., Neale BM, Ripke S., Shianna K., Szatkiewicz JP, Tropsha A., van den Oord EJ, Cascorbi I., Dettling M., Gazit E., Goff DC, Holden AL, Kelly DL, et al. Nature communications, 2014/09/04, Volume 5, p.4757, (2014) Read More / View Supplemental Materials
Abstract
Copy number variation in schizophrenia in Sweden.Szatkiewicz, JP, O'Dushlaine C., Chen G., Chambert K., Moran JL, Neale BM, Fromer M., Ruderfer D., Akterin S., Bergen SE, Kähler A., Magnusson PK, Kim Y., Crowley JJ, Rees E., Kirov G., O'Donovan MC, Owen MJ, Walters J., Scolnick E., et al. Molecular psychiatry, 2014/07/01, Volume 19, Issue 7, p.762-73, (2014) Read More / View Supplemental Materials
Abstract
Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.Bergen, SE, O'Dushlaine CT, Lee PH, Fanous AH, Ruderfer DM, Ripke S., International Schizophrenia Consortium, Swedish Schizophrenia Consortium, Sullivan PF, Smoller JW, Purcell SM, and Corvin A. Schizophrenia research, 2014/04/01, Volume 154, Issue 1-3, p.48-53, (2014) Read More / View Supplemental Materials
Abstract
A polygenic burden of rare disruptive mutations in schizophrenia.Purcell, SM, Moran JL, Fromer M., Ruderfer D., Solovieff N., Roussos P., O'Dushlaine C., Chambert K., Bergen SE, Kähler A., Duncan L., Stahl E., Genovese G., Fernández E., Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E., Shakir K., et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.185-90, (2014) Read More / View Supplemental Materials
Abstract
Comorbidity of Severe Psychotic Disorders With Measures of Substance Use.Hartz, SM, Pato CN, Medeiros H., Cavazos-Rehg P., Sobell JL, Knowles JA, Bierut LJ, Pato MT, for the Genomic Psychiatry Cohort Consortium, Abbott C., Azevedo MH, Belliveau R., Bevilacqua E., Bromet EJ, Buckley PF, Dewan MJ, Escamilla MA, Fanous AH, Fochtmann LJ, Kinkead R., et al. JAMA psychiatry, 2014/01/01, (2014) Read More / View Supplemental Materials
Abstract
Evidence that duplications of 22q11.2 protect against schizophrenia.Rees, E., Kirov G., Sanders A., Walters JT, Chambert KD, Shi J., Szatkiewicz J., O'Dushlaine C., Richards AL, Green EK, Jones I., Davies G., Legge SE, Moran JL, Pato C., Pato M., Genovese G., Levinson D., Duan J., Moy W., et al. Molecular psychiatry, 2014/01/01, Volume 19, Issue 1, p.37-40, (2014) Read More / View Supplemental Materials
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2013
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.Ruderfer, DM, Fanous AH, Ripke S., McQuillin A., Amdur RL, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Gejman PV, O'Donovan MC, Andreassen OA, Djurovic S., Hultman CM, Kelsoe JR, Jamain S., Landén M., Leboyer M., Nimgaonkar V., Nurnberger J., Smoller JW, et al. Molecular psychiatry, 2013/11/26, (2013) Read More / View Supplemental Materials
Abstract
Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'Robinson, EB, Howrigan D., Yang J., Ripke S., Anttila V., Duncan LE, Jostins L., Barrett JC, Medland SE, Macarthur DG, Breen G., O'Donovan MC, Wray NR, Devlin B., Daly M. J., Visscher PM, Sullivan PF, and Neale BM Molecular psychiatry, 2013/10/22, (2013) Read More / View Supplemental Materials
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.Ripke, S., O'Dushlaine C., Chambert K., Moran JL, Kähler AK, Akterin S., Bergen SE, Collins AL, Crowley JJ, Fromer M., Kim Y., Lee SH, Magnusson PK, Sanchez N., Stahl EA, Williams S., Wray NR, Xia K., Bettella F., Borglum AD, et al. Nature genetics, 2013/10/01, Volume 45, Issue 10, p.1150-9, (2013) Read More / View Supplemental Materials
Abstract
Mosaic copy number variation in schizophrenia.Ruderfer, DM, Chambert K., Moran J., Talkowski M., Chen ES, Gigek C., Gusella JF, Blackwood DH, Corvin A., Gurling HM, Hultman CM, Kirov G., Magnusson P., O'Donovan MC, Owen MJ, Pato C., St Clair D., Sullivan PF, Purcell SM, Sklar P., et al. European journal of human genetics : EJHG, 2013/01/16, (2013) Read More / View Supplemental Materials
Abstract
2012
Discovery and Statistical Genotyping of Copy-Number Variation from Whole-Exome Sequencing Depth.Fromer, M., Moran JL, Chambert K., Banks E., Bergen SE, Ruderfer DM, Handsaker RE, McCarroll SA, O'Donovan MC, Owen MJ, Kirov G., Sullivan PF, Hultman CM, Sklar P., and Purcell SM American journal of human genetics, 2012/10/05, Volume 91, Issue 4, p.597-607, (2012) Read More / View Supplemental Materials
Abstract
zCall: A Rare Variant Caller for Array-based Genotyping.Goldstein, JI, Crenshaw A., Carey J., Grant G., Maguire J., Fromer M., O'Dushlaine C., Moran JL, Chambert K., Stevens C., Swedish Schizophrenia Consortium, ARRA Autism Sequencing Consortium, Sklar P., Hultman CM, Purcell S., McCarroll S., Sullivan PF, Daly M. J., and Neale BM Bioinformatics (Oxford, England), 2012/07/27, (2012) Read More / View Supplemental Materials
Abstract
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.Bergen, SE, O'Dushlaine CT, Ripke S., Lee PH, Ruderfer DM, Akterin S., Moran JL, Chambert KD, Handsaker RE, Backlund L., Osby U., McCarroll S., Landen M., Scolnick EM, Magnusson PK, Lichtenstein P., Hultman CM, Purcell SM, Sklar P., and Sullivan PF Molecular psychiatry, 2012/06/12, (2012) Read More / View Supplemental Materials
Abstract
Exome sequencing and the genetic basis of complex traits.Kiezun, A., Garimella K., Do R., Stitziel NO, Neale BM, McLaren PJ, Gupta N., Sklar P., Sullivan PF, Moran JL, Hultman CM, Lichtenstein P., Magnusson P., Lehner T., Shugart YY, Price AL, de Bakker PI, Purcell SM, and Sunyaev SR Nature genetics, 2012/05/29, Volume 44, Issue 6, p.623-30, (2012) Read More / View Supplemental Materials
Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.Pasaniuc, B., Rohland N., McLaren PJ, Garimella K., Zaitlen N., Li H., Gupta N., Neale BM, Daly M. J., Sklar P., Sullivan PF, Bergen S., Moran JL, Hultman CM, Lichtenstein P., Magnusson P., Purcell SM, Haas DW, Liang L., Sunyaev S., et al. Nature genetics, 2012/05/20, Volume 44, Issue 6, p.631-5, (2012) Read More / View Supplemental Materials
Abstract
2007
New models of collaboration in genome-wide association studies: the Genetic Association Information Network.GAIN Collaborative Research, Group, Manolio TA, Rodriguez LL, Brooks L., Abecasis G., Collaborative Association Study of Psoriasis, Ballinger D., Daly M., Donnelly P., Faraone SV, International Multi-Center ADHD Genetics Project, Frazer K., Gabriel S., Gejman P., Molecular Genetics of Schizophrenia Collaboration, Guttmacher A., Harris EL, Insel T., Kelsoe JR, Bipolar Genome Study, et al. Nature genetics, 2007/09/01, Volume 39, Issue 9, p.1045-51, (2007) Read More / View Supplemental Materials
Abstract
  • Showing 1-35 of 35 Results