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2008
Somatic mutations affect key pathways in lung adenocarcinoma.Ding, L., Getz G., Wheeler DA, Mardis ER, McLellan MD, Cibulskis K., Sougnez C., Greulich H., Muzny DM, Morgan MB, Fulton L., Fulton RS, Zhang Q., Wendl MC, Lawrence MS, Larson DE, Chen K., Dooling DJ, Sabo A., Hawes AC, et al. Nature, 2008/10/23, Volume 455, Issue 7216, p.1069-75, (2008) Read More / View Supplemental Materials
Abstract
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.Ku, M., Koche RP, Rheinbay E., Mendenhall EM, Endoh M., Mikkelsen TS, Presser A., Nusbaum C., Xie X., Chi AS, Adli M., Kasif S., Ptaszek LM, Cowan CA, Lander E. S., Koseki H., and Bernstein BE PLoS genetics, 2008/10/01, Volume 4, Issue 10, p.e1000242, (2008) Read More / View Supplemental Materials
Abstract
Genome-scale DNA methylation maps of pluripotent and differentiated cells.Meissner, A., Mikkelsen TS, Gu H., Wernig M., Hanna J., Sivachenko A., Zhang X., Bernstein BE, Nusbaum C., Jaffe DB, Gnirke A., Jaenisch R., and Lander E. S. Nature, 2008/08/07, Volume 454, Issue 7205, p.766-70, (2008) Read More / View Supplemental Materials
Abstract
Dissecting direct reprogramming through integrative genomic analysis.Mikkelsen, TS, Hanna J., Zhang X., Ku M., Wernig M., Schorderet P., Bernstein BE, Jaenisch R., Lander E. S., and Meissner A. Nature, 2008/07/03, Volume 454, Issue 7200, p.49-55, (2008) Read More / View Supplemental Materials
Abstract
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways.Onder, TT, Gupta PB, Mani SA, Yang J., Lander E. S., and Weinberg R. A. Cancer research, 2008/05/15, Volume 68, Issue 10, p.3645-54, (2008) Read More / View Supplemental Materials
Abstract
ALLPATHS: de novo assembly of whole-genome shotgun microreads.Butler, J., Maccallum I., Kleber M., Shlyakhter IA, Belmonte MK, Lander E. S., Nusbaum C., and Jaffe DB Genome research, 2008/05/01, Volume 18, Issue 5, p.810-20, (2008) Read More / View Supplemental Materials
Abstract
Quality scores and SNP detection in sequencing-by-synthesis systems.Brockman, W., Alvarez P., Young S., Garber M., Giannoukos G., Lee WL, Russ C., Lander E. S., Nusbaum C., and Jaffe DB Genome research, 2008/05/01, Volume 18, Issue 5, p.763-70, (2008) Read More / View Supplemental Materials
Abstract
2007
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.Beroukhim, R., Getz G., Nghiemphu L., Barretina J., Hsueh T., Linhart D., Vivanco I., Lee JC, Huang JH, Alexander S., Du J., Kau T., Thomas RK, Shah K., Soto H., Perner S., Prensner J., Debiasi RM, Demichelis F., Hatton C., et al. Proceedings of the National Academy of Sciences of the United States of America, 2007/12/11, Volume 104, Issue 50, p.20007-12, (2007) Read More / View Supplemental Materials
Abstract
Characterizing the cancer genome in lung adenocarcinoma.Weir, BA, Woo MS, Getz G., Perner S., Ding L., Beroukhim R., Lin WM, Province MA, Kraja A., Johnson LA, Shah K., Sato M., Thomas RK, Barletta JA, Borecki IB, Broderick S., Chang AC, Chiang DY, Chirieac LR, Cho J., et al. Nature, 2007/12/06, Volume 450, Issue 7171, p.893-8, (2007) Read More / View Supplemental Materials
Abstract
Distinguishing protein-coding and noncoding genes in the human genome.Clamp, M., Fry B., Kamal M., Xie X., Cuff J., Lin MF, Kellis M., Lindblad-Toh K., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2007/12/04, Volume 104, Issue 49, p.19428-33, (2007) Read More / View Supplemental Materials
Abstract
28-way vertebrate alignment and conservation track in the UCSC Genome Browser.Miller, W., Rosenbloom K., Hardison RC, Hou M., Taylor J., Raney B., Burhans R., King DC, Baertsch R., Blankenberg D., Kosakovsky Pond SL, Nekrutenko A., Giardine B., Harris RS, Tyekucheva S., Diekhans M., Pringle TH, Murphy WJ, Lesk A., Weinstock GM, et al. Genome research, 2007/12/01, Volume 17, Issue 12, p.1797-808, (2007) Read More / View Supplemental Materials
Abstract
Efficient mapping of mendelian traits in dogs through genome-wide association.Karlsson, EK, Baranowska I., Wade CM, Salmon Hillbertz NH, Zody MC, Anderson N., Biagi TM, Patterson N., Pielberg GR, Kulbokas EJ 3rd, Comstock KE, Keller ET, Mesirov J. P., von Euler H., Kämpe O., Hedhammar A., Lander E. S., Andersson G., Andersson L., and Lindblad-Toh K. Nature genetics, 2007/11/01, Volume 39, Issue 11, p.1321-8, (2007) Read More / View Supplemental Materials
Abstract
Genome-wide detection and characterization of positive selection in human populations.Sabeti, PC, Varilly P., Fry B., Lohmueller J., Hostetter E., Cotsapas C., Xie X., Byrne EH, McCarroll SA, Gaudet R., Schaffner SF, Lander E. S., International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, et al. Nature, 2007/10/18, Volume 449, Issue 7164, p.913-8, (2007) Read More / View Supplemental Materials
Abstract
Comment on "The consensus coding sequences of human breast and colorectal cancers".Getz, G., Höfling H., Mesirov J. P., Golub T. R., Meyerson M., Tibshirani R., and Lander E. S. Science (New York, N.Y.), 2007/09/14, Volume 317, Issue 5844, p.1500, (2007) Read More / View Supplemental Materials
Abstract
Risk alleles for multiple sclerosis identified by a genomewide study.International Multiple Sclerosis Genetics, Consortium, Hafler DA, Compston A., Sawcer S., Lander E. S., Daly M. J., De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B., Oksenberg JR, and Hauser SL The New England journal of medicine, 2007/08/30, Volume 357, Issue 9, p.851-62, (2007) Read More / View Supplemental Materials
Abstract
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.Mikkelsen, TS, Ku M., Jaffe DB, Issac B., Lieberman E., Giannoukos G., Alvarez P., Brockman W., Kim TK, Koche RP, Lee W., Mendenhall E., O'Donovan A., Presser A., Russ C., Xie X., Meissner A., Wernig M., Jaenisch R., Nusbaum C., et al. Nature, 2007/08/02, Volume 448, Issue 7153, p.553-60, (2007) Read More / View Supplemental Materials
Abstract
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.Boehm, JS, Zhao JJ, Yao J., Kim SY, Firestein R., Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S., Richardson AL, Greulich H., Stewart CJ, Mulvey LA, Shen RR, Ambrogio L., Hirozane-Kishikawa T., Hill DE, Vidal M., Meyerson M., Grenier JK, et al. Cell, 2007/06/15, Volume 129, Issue 6, p.1065-79, (2007) Read More / View Supplemental Materials
Abstract
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.ENCODE Project, Consortium, Birney E., Stamatoyannopoulos JA, Dutta A., Guigó R., Gingeras TR, Margulies EH, Weng Z., Snyder M., Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S., Koch CM, Asthana S., Malhotra A., Adzhubei I., Greenbaum JA, Andrews RM, et al. Nature, 2007/06/14, Volume 447, Issue 7146, p.799-816, (2007) Read More / View Supplemental Materials
Abstract
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome.Margulies, EH, Cooper GM, Asimenos G., Thomas DJ, Dewey CN, Siepel A., Birney E., Keefe D., Schwartz AS, Hou M., Taylor J., Nikolaev S., Montoya-Burgos JI, Löytynoja A., Whelan S., Pardi F., Massingham T., Brown JB, Bickel P., Holmes I., et al. Genome research, 2007/06/01, Volume 17, Issue 6, p.760-74, (2007) Read More / View Supplemental Materials
Abstract
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.Mikkelsen, TS, Wakefield MJ, Aken B., Amemiya CT, Chang JL, Duke S., Garber M., Gentles AJ, Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle SM, Sharpe T., Baker ML, Batzer MA, Benos PV, Belov K., Clamp M., et al. Nature, 2007/05/10, Volume 447, Issue 7141, p.167-77, (2007) Read More / View Supplemental Materials
Abstract
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites.Xie, X., Mikkelsen TS, Gnirke A., Lindblad-Toh K., Kellis M., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2007/04/24, Volume 104, Issue 17, p.7145-50, (2007) Read More / View Supplemental Materials
Abstract
A second major histocompatibility complex susceptibility locus for multiple sclerosis.Yeo, TW, De Jager PL, Gregory SG, Barcellos LF, Walton A., Goris A., Fenoglio C., Ban M., Taylor CJ, Goodman RS, Walsh E., Wolfish CS, Horton R., Traherne J., Beck S., Trowsdale J., Caillier SJ, Ivinson AJ, Green T., Pobywajlo S., et al. Annals of neurology, 2007/03/01, Volume 61, Issue 3, p.228-36, (2007) Read More / View Supplemental Materials
Abstract
The mammalian epigenome.Bernstein, BE, Meissner A., and Lander E. S. Cell, 2007/02/23, Volume 128, Issue 4, p.669-81, (2007) Read More / View Supplemental Materials
Abstract
Sleep-related epilepsy in the A/J mouse.Strohl, KP, Gallaugher L., Lynn A., Friedman L., Hill A., Singer JB, Lander E. S., and Nadeau J. Sleep, 2007/02/01, Volume 30, Issue 2, p.169-76, (2007) Read More / View Supplemental Materials
Abstract
A genome-wide map of diversity in Plasmodium falciparum.Volkman, SK, Sabeti PC, DeCaprio D., Neafsey DE, Schaffner SF, Milner DA Jr, Daily JP, Sarr O., Ndiaye D., Ndir O., Mboup S., Duraisingh MT, Lukens A., Derr A., Stange-Thomann N., Waggoner S., Onofrio R., Ziaugra L., Mauceli E., Gnerre S., et al. Nature genetics, 2007/01/01, Volume 39, Issue 1, p.113-9, (2007) Read More / View Supplemental Materials
Abstract
2006
A second fatty acid amide hydrolase with variable distribution among placental mammals.Wei, BQ, Mikkelsen TS, McKinney MK, Lander E. S., and Cravatt BF The Journal of biological chemistry, 2006/12/01, Volume 281, Issue 48, p.36569-78, (2006) Read More / View Supplemental Materials
Abstract
Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida.Bourlat, SJ, Juliusdottir T., Lowe CJ, Freeman R., Aronowicz J., Kirschner M., Lander E. S., Thorndyke M., Nakano H., Kohn AB, Heyland A., Moroz LL, Copley RR, and Telford MJ Nature, 2006/11/02, Volume 444, Issue 7115, p.85-8, (2006) Read More / View Supplemental Materials
Abstract
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.Lamb, J., Crawford ED, Peck D., Modell JW, Blat IC, Wrobel MJ, Lerner J., Brunet JP, Subramanian A., Ross KN, Reich M., Hieronymus H., Wei G., Armstrong SA, Haggarty SJ, Clemons PA, Wei R., Carr SA, Lander E. S., and Golub T. R. Science (New York, N.Y.), 2006/09/29, Volume 313, Issue 5795, p.1929-35, (2006) Read More / View Supplemental Materials
Abstract
Genome-scale loss-of-function screening with a lentiviral RNAi library.Root, DE, Hacohen N., Hahn WC, Lander E. S., and Sabatini DM Nature methods, 2006/09/01, Volume 3, Issue 9, p.715-9, (2006) Read More / View Supplemental Materials
Abstract
A family of conserved noncoding elements derived from an ancient transposable element.Xie, X., Kamal M., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2006/08/01, Volume 103, Issue 31, p.11659-64, (2006) Read More / View Supplemental Materials
Abstract
Genetic evidence for complex speciation of humans and chimpanzees.Patterson, N., Richter DJ, Gnerre S., Lander E. S., and Reich D. Nature, 2006/06/29, Volume 441, Issue 7097, p.1103-8, (2006) Read More / View Supplemental Materials
Abstract
Positive natural selection in the human lineage.Sabeti, PC, Schaffner SF, Fry B., Lohmueller J., Varilly P., Shamovsky O., Palma A., Mikkelsen TS, Altshuler D., and Lander E. S. Science (New York, N.Y.), 2006/06/16, Volume 312, Issue 5780, p.1614-20, (2006) Read More / View Supplemental Materials
Abstract
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.Bernstein, BE, Mikkelsen TS, Xie X., Kamal M., Huebert DJ, Cuff J., Fry B., Meissner A., Wernig M., Plath K., Jaenisch R., Wagschal A., Feil R., Schreiber SL, and Lander E. S. Cell, 2006/04/21, Volume 125, Issue 2, p.315-26, (2006) Read More / View Supplemental Materials
Abstract
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.Zody, MC, Garber M., Adams DJ, Sharpe T., Harrow J., Lupski JR, Nicholson C., Searle SM, Wilming L., Young SK, Abouelleil A., Allen NR, Bi W., Bloom T., Borowsky ML, Bugalter BE, Butler J., Chang JL, Chen CK, Cook A., et al. Nature, 2006/04/20, Volume 440, Issue 7087, p.1045-9, (2006) Read More / View Supplemental Materials
Abstract
Reactive oxygen species have a causal role in multiple forms of insulin resistance.Houstis, N., Rosen ED, and Lander E. S. Nature, 2006/04/13, Volume 440, Issue 7086, p.944-8, (2006) Read More / View Supplemental Materials
Abstract
Identification and classification of conserved RNA secondary structures in the human genome.Pedersen, JS, Bejerano G., Siepel A., Rosenbloom K., Lindblad-Toh K., Lander E. S., Kent J., Miller W., and Haussler D. PLoS computational biology, 2006/04/01, Volume 2, Issue 4, p.e33, (2006) Read More / View Supplemental Materials
Abstract
Analysis of the DNA sequence and duplication history of human chromosome 15.Zody, MC, Garber M., Sharpe T., Young SK, Rowen L., O'Neill K., Whittaker CA, Kamal M., Chang JL, Cuomo CA, Dewar K., FitzGerald MG, Kodira CD, Madan A., Qin S., Yang X., Abbasi N., Abouelleil A., Arachchi HM, Baradarani L., et al. Nature, 2006/03/30, Volume 440, Issue 7084, p.671-5, (2006) Read More / View Supplemental Materials
Abstract
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.Moffat, J., Grueneberg DA, Yang X., Kim SY, Kloepfer AM, Hinkle G., Piqani B., Eisenhaure TM, Luo B., Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N., Hahn WC, Lander E. S., Sabatini DM, and Root DE Cell, 2006/03/24, Volume 124, Issue 6, p.1283-98, (2006) Read More / View Supplemental Materials
Abstract
Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor, TD, Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim DW, She X., Barlow KF, Bloom T., Bruford E., Chang JL, Cuomo CA, Eichler E., FitzGerald MG, Jaffe DB, LaButti K., et al. Nature, 2006/03/23, Volume 440, Issue 7083, p.497-500, (2006) Read More / View Supplemental Materials
Abstract
Searching for signals of evolutionary selection in 168 genes related to immune function.Walsh, EC, Sabeti P., Hutcheson HB, Fry B., Schaffner SF, de Bakker PI, Varilly P., Palma AA, Roy J., Cooper R., Winkler C., Zeng Y., de The G., Lander E. S., O'Brien S., and Altshuler D. Human genetics, 2006/03/01, Volume 119, Issue 1-2, p.92-102, (2006) Read More / View Supplemental Materials
Abstract
A large family of ancient repeat elements in the human genome is under strong selection.Kamal, M., Xie X., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2006/02/21, Volume 103, Issue 8, p.2740-5, (2006) Read More / View Supplemental Materials
Abstract
DNA sequence and analysis of human chromosome 8.Nusbaum, C., Mikkelsen TS, Zody MC, Asakawa S., Taudien S., Garber M., Kodira CD, Schueler MG, Shimizu A., Whittaker CA, Chang JL, Cuomo CA, Dewar K., FitzGerald MG, Yang X., Allen NR, Anderson S., Asakawa T., Blechschmidt K., Bloom T., et al. Nature, 2006/01/19, Volume 439, Issue 7074, p.331-5, (2006) Read More / View Supplemental Materials
Abstract
2005
Genome sequence, comparative analysis and haplotype structure of the domestic dog.Lindblad-Toh, K., Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M., Clamp M., Chang JL, Kulbokas EJ 3rd, Zody MC, Mauceli E., Xie X., Breen M., Wayne RK, Ostrander EA, Ponting CP, Galibert F., Smith DR, de Jong PJ, Kirkness E., et al. Nature, 2005/12/08, Volume 438, Issue 7069, p.803-19, (2005) Read More / View Supplemental Materials
Abstract
The case for selection at CCR5-Delta32.Sabeti, PC, Walsh E., Schaffner SF, Varilly P., Fry B., Hutcheson HB, Cullen M., Mikkelsen TS, Roy J., Patterson N., Cooper R., Reich D., Altshuler D., O'Brien S., and Lander E. S. PLoS biology, 2005/11/01, Volume 3, Issue 11, p.e378, (2005) Read More / View Supplemental Materials
Abstract
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Subramanian, A., Tamayo P., Mootha VK, Mukherjee S., Ebert BL, Gillette MA, Paulovich A., Pomeroy SL, Golub T. R., Lander E. S., and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25, Volume 102, Issue 43, p.15545-50, (2005) Read More / View Supplemental Materials
Abstract
DNA sequence and analysis of human chromosome 18.Nusbaum, C., Zody MC, Borowsky ML, Kamal M., Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K., FitzGerald MG, Yang X., Abouelleil A., Allen NR, Anderson S., Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., et al. Nature, 2005/09/22, Volume 437, Issue 7058, p.551-5, (2005) Read More / View Supplemental Materials
Abstract
A high-density screen for linkage in multiple sclerosis.Sawcer, S., Ban M., Maranian M., Yeo TW, Compston A., Kirby A., Daly M. J., De Jager PL, Walsh E., Lander E. S., Rioux JD, Hafler DA, Ivinson A., Rimmler J., Gregory SG, Schmidt S., Pericak-Vance MA, Akesson E., Hillert J., Datta P., et al. American journal of human genetics, 2005/09/01, Volume 77, Issue 3, p.454-67, (2005) Read More / View Supplemental Materials
Abstract
Assembly of polymorphic genomes: algorithms and application to Ciona savignyi.Vinson, JP, Jaffe DB, O'Neill K., Karlsson EK, Stange-Thomann N., Anderson S., Mesirov J. P., Satoh N., Satou Y., Nusbaum C., Birren B., Galagan JE, and Lander E. S. Genome research, 2005/08/01, Volume 15, Issue 8, p.1127-35, (2005) Read More / View Supplemental Materials
Abstract
A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.Miretti, MM, Walsh EC, Ke X., Delgado M., Griffiths M., Hunt S., Morrison J., Whittaker P., Lander E. S., Cardon LR, Bentley DR, Rioux JD, Beck S., and Deloukas P. American journal of human genetics, 2005/04/01, Volume 76, Issue 4, p.634-46, (2005) Read More / View Supplemental Materials
Abstract
An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing.Margulies, EH, Vinson JP, NISC Comparative Sequencing Program, Miller W., Jaffe DB, Lindblad-Toh K., Chang JL, Green ED, Lander E. S., Mullikin JC, and Clamp M. Proceedings of the National Academy of Sciences of the United States of America, 2005/03/29, Volume 102, Issue 13, p.4795-800, (2005) Read More / View Supplemental Materials
Abstract
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.Xie, X., Lu J., Kulbokas E. J., Golub T. R., Mootha V., Lindblad-Toh K., Lander E. S., and Kellis M. Nature, 2005/03/17, Volume 434, Issue 7031, p.338-45, (2005) Read More / View Supplemental Materials
Abstract
Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.Singer, JB, Hill AE, Nadeau JH, and Lander E. S. Genetics, 2005/02/01, Volume 169, Issue 2, p.855-62, (2005) Read More / View Supplemental Materials
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Genomic maps and comparative analysis of histone modifications in human and mouse.Bernstein, BE, Kamal M., Lindblad-Toh K., Bekiranov S., Bailey DK, Huebert DJ, McMahon S., Karlsson EK, Kulbokas EJ 3rd, Gingeras TR, Schreiber SL, and Lander E. S. Cell, 2005/01/28, Volume 120, Issue 2, p.169-81, (2005) Read More / View Supplemental Materials
Abstract
2004
A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.Poirier, C., Qin Y., Adams CP, Anaya Y., Singer JB, Hill AE, Lander E. S., Nadeau JH, and Bishop CE Genetics, 2004/11/01, Volume 168, Issue 3, p.1557-62, (2004) Read More / View Supplemental Materials
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Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.Rioux, JD, Karinen H., Kocher K., McMahon SG, Kärkkäinen P., Janatuinen E., Heikkinen M., Julkunen R., Pihlajamäki J., Naukkarinen A., Kosma VM, Daly M. J., Lander E. S., and Laakso M. American journal of medical genetics. Part A, 2004/11/01, Volume 130A, Issue 4, p.345-50, (2004) Read More / View Supplemental Materials
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Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype.Jaillon, O., Aury JM, Brunet F., Petit JL, Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M., Levy M., Boudet N., et al. Nature, 2004/10/21, Volume 431, Issue 7011, p.946-57, (2004) Read More / View Supplemental Materials
Abstract
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.Michalkiewicz, M., Michalkiewicz T., Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B., MacMurray AJ, Kwitek AE, Jacob HJ, Lander E. S., and Lernmark A. Physiological genomics, 2004/10/04, Volume 19, Issue 2, p.228-32, (2004) Read More / View Supplemental Materials
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Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains.Krewson, TD, Supelak PJ, Hill AE, Singer JB, Lander E. S., Nadeau JH, and Palmert MR Endocrinology, 2004/10/01, Volume 145, Issue 10, p.4447-51, (2004) Read More / View Supplemental Materials
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Transcriptional regulatory code of a eukaryotic genome.Harbison, CT, Gordon DB, Lee TI, Rinaldi NJ, Macisaac KD, Danford TW, Hannett NM, Tagne JB, Reynolds DB, Yoo J., Jennings EG, Zeitlinger J., Pokholok DK, Kellis M., Rolfe PA, Takusagawa KT, Lander E. S., Gifford DK, Fraenkel E., and Young RA Nature, 2004/09/02, Volume 431, Issue 7004, p.99-104, (2004) Read More / View Supplemental Materials
Abstract
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.Sawcer, SJ, Maranian M., Singlehurst S., Yeo T., Compston A., Daly M. J., De Jager PL, Gabriel S., Hafler DA, Ivinson AJ, Lander E. S., Rioux JD, Walsh E., Gregory SG, Schmidt S., Pericak-Vance MA, Barcellos L., Hauser SL, Oksenberg JR, Kenealy SJ, et al. Human molecular genetics, 2004/09/01, Volume 13, Issue 17, p.1943-9, (2004) Read More / View Supplemental Materials
Abstract
Eric S. Lander.Lander, E. S. Nature reviews. Drug discovery, 2004/09/01, Volume 3, Issue 9, p.730, (2004) Read More / View Supplemental Materials
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.Mootha, VK, Handschin C., Arlow D., Xie X., St Pierre J., Sihag S., Yang W., Altshuler D., Puigserver P., Patterson N., Willy PJ, Schulman IG, Heyman RA, Lander E. S., and Spiegelman BM Proceedings of the National Academy of Sciences of the United States of America, 2004/04/27, Volume 101, Issue 17, p.6570-5, (2004) Read More / View Supplemental Materials
Abstract
Genetic dissection of complex traits with chromosome substitution strains of mice.Singer, JB, Hill AE, Burrage LC, Olszens KR, Song J., Justice M., O'Brien WE, Conti DV, Witte JS, Lander E. S., and Nadeau JH Science (New York, N.Y.), 2004/04/16, Volume 304, Issue 5669, p.445-8, (2004) Read More / View Supplemental Materials
Abstract
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae.Kellis, M., Birren BW, and Lander E. S. Nature, 2004/04/08, Volume 428, Issue 6983, p.617-24, (2004) Read More / View Supplemental Materials
Abstract
Assessing the impact of population stratification on genetic association studies.Freedman, ML, Reich D., Penney KL, McDonald GJ, Mignault AA, Patterson N., Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander E. S., Sklar P., Henderson B., Hirschhorn JN, and Altshuler D. Nature genetics, 2004/04/01, Volume 36, Issue 4, p.388-93, (2004) Read More / View Supplemental Materials
Abstract
2001
Multiclass cancer diagnosis using tumor gene expression signaturesRamaswamy, S., Tamayo P., Rifkin R., Mukherjee S., Yeang C. H., Angelo M., Ladd C., Reich M., Latulippe E., Mesirov J. P., Poggio T., Gerald W., Loda M., Lander E. S., and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2001/12/18/, Volume 98, Issue 26, p.15149 - 54, (2001) Read More / View Supplemental Materials
Abstract
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclassesBhattacharjee, A., Richards W. G., Staunton J., Li C., Monti S., Vasa P., Ladd C., Beheshti J., Bueno R., Gillette M., Loda M., Weber G., Mark E. J., Lander E. S., Wong W., Johnson B. E., Golub T. R., Sugarbaker D. J., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2001/11/20/, Volume 98, Issue 24, p.13790 - 5, (2001) Read More / View Supplemental Materials
Abstract
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclassesBhattacharjee, A., Richards W. G., Staunton J., Li C., Monti S., Vasa P., Ladd C., Beheshti J., Bueno R., Gillette M., Loda M., Weber G., Mark E. J., Lander E. S., Wong W., Johnson B. E., Golub T. R., Sugarbaker D. J., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2001/11/20/, Volume 98, Issue 24, p.13790 - 5, (2001) Read More / View Supplemental Materials
Abstract
Chemosensitivity prediction by transcriptional profilingStaunton, J. E., Slonim D. K., Coller H. A., Tamayo P., Angelo M. J., Park J., Scherf U., Lee J. K., Reinhold W. O., Weinstein J. N., Mesirov J. P., Lander E. S., and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2001/09/11/, Volume 98, Issue 19, p.10787 - 92, (2001) Read More / View Supplemental Materials
Abstract
2000
Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arraysLindblad-Toh, K., Tanenbaum D. M., Daly M. J., Winchester E., Lui W. O., Villapakkam A., Stanton S. E., Larsson C., Hudson T. J., Johnson B. E., Lander E. S., and Meyerson M. Nature Biotechnology, 2000/09//, Volume 18, Issue 9, p.1001 - 5, (2000) Read More / View Supplemental Materials
Abstract
Genomic analysis of metastasis reveals an essential role for RhoCClark, E. A., Golub T. R., Lander E. S., and Hynes R. O. Nature, 2000/08/03/, Volume 406, Issue 6795, p.532 - 5, (2000) Read More / View Supplemental Materials
Abstract
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesionColler, H. A., Grandori C., Tamayo P., Colbert T., Lander E. S., Eisenman R. N., and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2000/03/28/, Volume 97, Issue 7, p.3260 - 5, (2000) Read More / View Supplemental Materials
Abstract
GENOMICS: Journey to the Center of BiologyLander, E. S., and Weinberg R. A. Science (New York, N.Y.), 2000/03/10/, Volume 287, Issue 5459, p.1777 - 82, (2000) Read More / View Supplemental Materials
1999
Molecular classification of cancer: class discovery and class prediction by gene expression monitoringGolub, T. R., Slonim D. K., Tamayo P., Huard C., Gaasenbeek M., Mesirov J. P., Coller H., Loh M. L., Downing J. R., Caligiuri M. A., Bloomfield C. D., and Lander E. S. Science (New York, N.Y.), 1999/10/15/, Volume 286, Issue 5439, p.531 - 7, (1999) Read More / View Supplemental Materials
Abstract
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genesFambrough, D., McClure K., Kazlauskas A., and Lander E. S. Cell, 1999/06/11/, Volume 97, Issue 6, p.727 - 41, (1999) Read More / View Supplemental Materials
Abstract
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiationTamayo, P., Slonim D., Mesirov J., Zhu Q., Kitareewan S., Dmitrovsky E., Lander E. S., and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 1999/03/16/, Volume 96, Issue 6, p.2907 - 12, (1999) Read More / View Supplemental Materials
Abstract
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