Scientific Publications

Global nucleosome occupancy in yeast.Bernstein, BE, Liu CL, Humphrey EL, Perlstein EO, and Schreiber SL Genome biology, 2011/12/08, Volume 5, Issue 9, p.R62, (2011) Read More / View Supplemental Materials

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Abstract

Using expression and genotype to predict drug response in yeast.Ruderfer, DM, Roberts DC, Schreiber SL, Perlstein EO, and Kruglyak L. PloS one, 2009/09/04, Volume 4, Issue 9, p.e6907, (2009) Read More / View Supplemental Materials

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Abstract

Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast.de Bivort, BL, Perlstein EO, Kunes S., and Schreiber SL Journal of molecular evolution, 2009/05/01, Volume 68, Issue 5, p.490-7, (2009) Read More / View Supplemental Materials

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Abstract

Evolutionarily conserved optimization of amino acid biosynthesis.Perlstein, EO, de Bivort BL, Kunes S., and Schreiber SL Journal of molecular evolution, 2007/08/01, Volume 65, Issue 2, p.186-96, (2007) Read More / View Supplemental Materials

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Abstract

Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations.Perlstein, EO, Deeds EJ, Ashenberg O., Shakhnovich EI, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2007/06/19, Volume 104, Issue 25, p.10553-8, (2007) Read More / View Supplemental Materials

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Abstract

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.Sarkar, S., Perlstein EO, Imarisio S., Pineau S., Cordenier A., Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, and Rubinsztein DC Nature chemical biology, 2007/06/01, Volume 3, Issue 6, p.331-8, (2007) Read More / View Supplemental Materials

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Abstract

Genetic basis of individual differences in the response to small-molecule drugs in yeast.Perlstein, EO, Ruderfer DM, Roberts DC, Schreiber SL, and Kruglyak L. Nature genetics, 2007/04/01, Volume 39, Issue 4, p.496-502, (2007) Read More / View Supplemental Materials

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Abstract

Revealing complex traits with small molecules and naturally recombinant yeast strains.Perlstein, EO, Ruderfer DM, Ramachandran G., Haggarty SJ, Kruglyak L., and Schreiber SL Chemistry & biology, 2006/03/01, Volume 13, Issue 3, p.319-27, (2006) Read More / View Supplemental Materials

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Abstract

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.Butcher, RA, Bhullar BS, Perlstein EO, Marsischky G., LaBaer J., and Schreiber SL Nature chemical biology, 2006/02/01, Volume 2, Issue 2, p.103-9, (2006) Read More / View Supplemental Materials

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Abstract

A library of spirooxindoles based on a stereoselective three-component coupling reaction.Lo, MM, Neumann CS, Nagayama S., Perlstein EO, and Schreiber SL Journal of the American Chemical Society, 2004/12/15, Volume 126, Issue 49, p.16077-86, (2004) Read More / View Supplemental Materials

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Abstract

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.Floto, RA, Sarkar S., Perlstein EO, Kampmann B., Schreiber SL, and Rubinsztein DC Autophagy, 1969/12/31, Volume 3, Issue 6, p.620-2, (1969) Read More / View Supplemental Materials

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Abstract