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2014
Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells.Chen, WW, Birsoy K., Mihaylova MM, Snitkin H., Stasinski I., Yucel B., Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, and Sabatini DM Cell reports, 2014/04/10, Volume 7, Issue 1, p.27-34, (2014) Read More / View Supplemental Materials
Abstract
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Birsoy, K., Possemato R., Lorbeer FK, Bayraktar EC, Thiru P., Yucel B., Wang T., Chen WW, Clish CB, and Sabatini DM Nature, 2014/04/03, Volume 508, Issue 7494, p.108-12, (2014) Read More / View Supplemental Materials
Abstract
Regulation of mTORC1 by amino acids.Bar-Peled, L., and Sabatini DM Trends in cell biology, 2014/03/31, (2014) Read More / View Supplemental Materials
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Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib.Wagle, N., Grabiner BC, Van Allen EM, Hodis E., Jacobus S., Supko JG, Stewart M., Choueiri TK, Gandhi L., Cleary JM, Elfiky AA, Taplin ME, Stack EC, Signoretti S., Loda M., Shapiro GI, Sabatini DM, Lander E. S., Gabriel SB, Kantoff PW, et al. Cancer discovery, 2014/03/27, (2014) Read More / View Supplemental Materials
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Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer.Mihaylova, MM, Sabatini DM, and Yilmaz OH Cell stem cell, 2014/03/06, Volume 14, Issue 3, p.292-305, (2014) Read More / View Supplemental Materials
Abstract
ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State.Chudnovsky, Y., Kim D., Zheng S., Whyte WA, Bansal M., Bray MA, Gopal S., Theisen MA, Bilodeau S., Thiru P., Muffat J., Yilmaz OH, Mitalipova M., Woolard K., Lee J., Nishimura R., Sakata N., Fine HA, Carpenter AE, Silver SJ, et al. Cell reports, 2014/01/15, (2014) Read More / View Supplemental Materials
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2013
A Central Role for mTOR in Lipid Homeostasis.Lamming, DW, and Sabatini DM Cell metabolism, 2013/10/01, Volume 18, Issue 4, p.465-469, (2013) Read More / View Supplemental Materials
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Nutrients and growth factors in mTORC1 activation.Efeyan, A., and Sabatini DM Biochemical Society transactions, 2013/08/01, Volume 41, Issue 4, p.902-5, (2013) Read More / View Supplemental Materials
Abstract
Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.Lamming, DW, Ye L., Astle CM, Baur JA, Sabatini DM, and Harrison DE Aging cell, 2013/05/04, (2013) Read More / View Supplemental Materials
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2012
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.Efeyan, A., Zoncu R., Chang S., Gumper I., Snitkin H., Wolfson RL, Kirak O., Sabatini DD, and Sabatini DM Nature, 2012/12/23, (2012) Read More / View Supplemental Materials
Abstract
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Birsoy, K., Wang T., Possemato R., Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y., Peterson TR, Carette JE, Brummelkamp TR, Clish CB, and Sabatini DM Nature genetics, 2012/12/16, Volume 45, Issue 1, p.104-8, (2012) Read More / View Supplemental Materials
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Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.Birsoy, K., Sabatini DM, and Possemato R. Nature medicine, 2012/07/06, Volume 18, Issue 7, p.1022-3, (2012) Read More / View Supplemental Materials
Amino acids and mTORC1: from lysosomes to disease.Efeyan, A., Zoncu R., and Sabatini DM Trends in molecular medicine, 2012/06/27, (2012) Read More / View Supplemental Materials
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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.Yilmaz, OH, Katajisto P., Lamming DW, Gültekin Y., Bauer-Rowe KE, Sengupta S., Birsoy K., Dursun A., Yilmaz VO, Selig M., Nielsen GP, Mino-Kenudson M., Zukerberg LR, Bhan AK, Deshpande V., and Sabatini DM Nature, 2012/05/20, (2012) Read More / View Supplemental Materials
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2011
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.Reiling, JH, Clish CB, Carette JE, Varadarajan M., Brummelkamp TR, and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11756-65, (2011) Read More / View Supplemental Materials
Abstract
2010
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.Boulbes, D., Chen CH, Shaikenov T., Agarwal NK, Peterson TR, Addona TA, Keshishian H., Carr SA, Magnuson MA, Sabatini DM, and Sarbassov dos D. Molecular cancer research : MCR, 2010/06/01, Volume 8, Issue 6, p.896-906, (2010) Read More / View Supplemental Materials
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2009
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.Barbie, DA, Tamayo P., Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P., Meylan E., Scholl C., Fröhling S., Chan EM, Sos ML, Michel K., Mermel C., Silver SJ, Weir BA, Reiling JH, Sheng Q., Gupta PB, et al. Nature, 2009/11/05, Volume 462, Issue 7269, p.108-12, (2009) Read More / View Supplemental Materials
Abstract
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning.Jones, TR, Carpenter AE, Lamprecht MR, Moffat J., Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P., and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2009/02/10, Volume 106, Issue 6, p.1826-31, (2009) Read More / View Supplemental Materials
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2008
Highly parallel identification of essential genes in cancer cells.Luo, B., Cheung HW, Subramanian A., Sharifnia T., Okamoto M., Yang X., Hinkle G., Boehm JS, Beroukhim R., Weir BA, Mermel C., Barbie DA, Awad T., Zhou X., Nguyen T., Piqani B., Li C., Golub T. R., Meyerson M., Hacohen N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/12/23, Volume 105, Issue 51, p.20380-5, (2008) Read More / View Supplemental Materials
Abstract
CellProfiler Analyst: data exploration and analysis software for complex image-based screens.Jones, TR, Kang IH, Wheeler DB, Lindquist RA, Papallo A., Sabatini DM, Golland P., and Carpenter AE BMC bioinformatics, 2008/11/15, Volume 9, p.482, (2008) Read More / View Supplemental Materials
Abstract
2007
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.Sancak, Y., Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E., Carr SA, and Sabatini DM Molecular cell, 2007/03/23, Volume 25, Issue 6, p.903-15, (2007) Read More / View Supplemental Materials
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2006
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.Frias, MA, Thoreen CC, Jaffe JD, Schroder W., Sculley T., Carr SA, and Sabatini DM Current biology : CB, 2006/09/19, Volume 16, Issue 18, p.1865-70, (2006) Read More / View Supplemental Materials
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Genome-scale loss-of-function screening with a lentiviral RNAi library.Root, DE, Hacohen N., Hahn WC, Lander E. S., and Sabatini DM Nature methods, 2006/09/01, Volume 3, Issue 9, p.715-9, (2006) Read More / View Supplemental Materials
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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.Moffat, J., Grueneberg DA, Yang X., Kim SY, Kloepfer AM, Hinkle G., Piqani B., Eisenhaure TM, Luo B., Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N., Hahn WC, Lander E. S., Sabatini DM, and Root DE Cell, 2006/03/24, Volume 124, Issue 6, p.1283-98, (2006) Read More / View Supplemental Materials
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