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2014
Pathways targeted by anti-diabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.Segrè, AV, Wei N., DIAGRAM Consortium, investigators MAGIC, Altshuler D., and Florez JC Diabetes, 2014/11/03, (2014) Read More / View Supplemental Materials
Abstract
Effect of phosphodiesterase inhibition on insulin resistance in obese individuals.Ho, JE, Arora P., Walford GA, Ghorbani A., Guanaga DP, Dhakal BP, Nathan DI, Buys ES, Florez JC, Newton-Cheh C., Lewis GD, and Wang TJ Journal of the American Heart Association, 2014/09/11, Volume 3, Issue 5, (2014) Read More / View Supplemental Materials
Abstract
Metformin pharmacogenomics: current status and future directions.Pawlyk, AC, Giacomini KM, McKeon C., Shuldiner AR, and Florez JC Diabetes, 2014/08/01, Volume 63, Issue 8, p.2590-9, (2014) Read More / View Supplemental Materials
Abstract
Effects of Weight Loss, Weight Cycling, and Weight Loss Maintenance on Diabetes Incidence and Change in Cardiometabolic Traits in the Diabetes Prevention Program.Delahanty, LM, Pan Q., Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L., Franks PW, and for the Diabetes Prevention Program Research Group Diabetes care, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.Vimaleswaran, KS, Cavadino A., Berry DJ, investigators LifeLines Cohort Study, Jorde R., Dieffenbach AK, Lu C., Alves AC, Heerspink HJ, Tikkanen E., Eriksson J., Wong A., Mangino M., Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D., Zgaga L., et al. The lancet. Diabetes & endocrinology, 2014/06/25, (2014) Read More / View Supplemental Materials
Abstract
Metabolite Traits and Genetic Risk Provide Complementary Information for the Prediction of Future Type 2 Diabetes.Walford, GA, Porneala BC, Dauriz M., Vassy JL, Cheng S., Rhee EP, Wang TJ, Meigs JB, Gerszten RE, and Florez JC Diabetes care, 2014/06/19, (2014) Read More / View Supplemental Materials
Abstract
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.Consortium, SIGMA Type Diabetes 2, Estrada K., Aukrust I., Bjørkhaug L., Burtt NP, Mercader JM, García-Ortiz H., Huerta-Chagoya A., Moreno-Macías H., Walford G., Flannick J., Williams AL, Gómez-Vázquez MJ, Fernandez-Lopez JC, Martínez-Hernández A., Centeno-Cruz F., Mendoza-Caamal E., Revilla-Monsalve C., Islas-Andrade S., Córdova EJ, et al. JAMA : the journal of the American Medical Association, 2014/06/11, Volume 311, Issue 22, p.2305-14, (2014) Read More / View Supplemental Materials
Abstract
Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes.Florez, JC JAMA : the journal of the American Medical Association, 2014/01/15, Volume 311, Issue 3, p.249-51, (2014) Read More / View Supplemental Materials
2013
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.The SIGMA Type 2 Diabetes, Consortium, team Writing, Williams AL, Jacobs SB, Moreno-Macías H., Huerta-Chagoya A., Churchhouse C., Márquez-Luna C., García-Ortíz H., José Gómez-Vázquez M., Burtt NP, Aguilar-Salinas CA, González-Villalpando C., Florez JC, Orozco L., Haiman CA, Tusié-Luna T., Altshuler D., team Analysis, Williams AL, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
Abstract
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.Flannick, J., Beer NL, Bick AG, Agarwala V., Molnes J., Gupta N., Burtt NP, Florez JC, Meigs JB, Taylor H., Lyssenko V., Irgens H., Fox E., Burslem F., Johansson S., Brosnan MJ, Trimmer JK, Newton-Cheh C., Tuomi T., Molven A., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1380-5, (2013) Read More / View Supplemental Materials
Abstract
A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort.Rhee, EP, Ho JE, Chen MH, Shen D., Cheng S., Larson MG, Ghorbani A., Shi X., Helenius IT, O'Donnell CJ, Souza AL, Deik A., Pierce KA, Bullock K., Walford GA, Vasan RS, Florez JC, Clish C., Yeh JR, Wang TJ, et al. Cell metabolism, 2013/07/02, Volume 18, Issue 1, p.130-43, (2013) Read More / View Supplemental Materials
Abstract
Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study.de Miguel-Yanes, JM, Porneala B., Pencina MJ, Fox CS, Florez JC, Siscovick DS, Dupuis J., and Meigs JB Journal of hypertension, 2013/02/19, (2013) Read More / View Supplemental Materials
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2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Manning, AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N., Chen H., Rybin D., Liu CT, Bielak LF, Prokopenko I., Amin N., Barnes D., Cadby G., Hottenga JJ, Ingelsson E., Jackson AU, Johnson T., Kanoni S., Ladenvall C., Lagou V., et al. Nature genetics, 2012/05/13, Volume 44, Issue 6, p.659-669, (2012) Read More / View Supplemental Materials
Abstract
Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.Mather, KJ, Christophi CA, Jablonski KA, Knowler WC, Goldberg RB, Kahn SE, Spector T., Dastani Z., Waterworth D., Richards JB, Funahashi T., Pi-Sunyer FX, Pollin TI, Florez JC, Franks PW, and for the Diabetes Prevention Program Research Group Diabetic medicine : a journal of the British Diabetic Association, 2012/03/24, (2012) Read More / View Supplemental Materials
Abstract
Effects of genetic variants previously associated with fasting glucose and insulin in the diabetes prevention program.Florez, JC, Jablonski KA, McAteer JB, Franks PW, Mason CC, Mather K., Horton E., Goldberg R., Dabelea D., Kahn SE, Arakaki RF, Shuldiner AR, Knowler WC, and Diabetes Prevention Program Research Group PloS one, 2012/01/01, Volume 7, Issue 9, p.e44424, (2012) Read More / View Supplemental Materials
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2011
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.Rhee, EP, Cheng S., Larson MG, Walford GA, Lewis GD, McCabe E., Yang E., Farrell L., Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, and Gerszten RE The Journal of clinical investigation, 2011/04/01, Volume 121, Issue 4, p.1402-11, (2011) Read More / View Supplemental Materials
Abstract
Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials
Abstract
2010
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Voight, BF, Scott LJ, Steinthorsdottir V., Morris AP, Dina C., Welch RP, Zeggini E., Huth C., Aulchenko YS, Thorleifsson G., McCulloch LJ, Ferreira T., Grallert H., Amin N., Wu G., Willer CJ, Raychaudhuri S., McCarroll SA, Langenberg C., Hofmann OM, et al. Nature genetics, 2010/07/01, Volume 42, Issue 7, p.579-89, (2010) Read More / View Supplemental Materials
Abstract
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Saxena, R., Hivert MF, Langenberg C., Tanaka T., Pankow JS, Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson AU, Kao WH, Li M., Glazer NL, Manning AK, Luan J., Stringham HM, Prokopenko I., Johnson T., Grarup N., Boesgaard TW, et al. Nature genetics, 2010/02/01, Volume 42, Issue 2, p.142-8, (2010) Read More / View Supplemental Materials
Abstract
2007
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.and of Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes BioMedical Rese, Saxena R., Voight BF, Lyssenko V., Burtt NP, de Bakker PI, Chen H., Roix JJ, Kathiresan S., Hirschhorn JN, Daly M. J., Hughes TE, Groop L., Altshuler D., Almgren P., Florez JC, Meyer J., Ardlie K., Bengtsson Boström K., Isomaa B., et al. Science (New York, N.Y.), 2007/06/01, Volume 316, Issue 5829, p.1331-6, (2007) Read More / View Supplemental Materials
Abstract
2006
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.Saxena, R., Gianniny L., Burtt NP, Lyssenko V., Giuducci C., Sjögren M., Florez JC, Almgren P., Isomaa B., Orho-Melander M., Lindblad U., Daly M. J., Tuomi T., Hirschhorn JN, Ardlie KG, Groop LC, and Altshuler D. Diabetes, 2006/10/01, Volume 55, Issue 10, p.2890-5, (2006) Read More / View Supplemental Materials
Abstract
  • Showing 1-21 of 21 Results