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2015
Steroid sex hormones, sex hormone binding globulin and diabetes incidence in the Diabetes Prevention Program.Mather, KM, Kim C., Christophi CA, Aroda VR, Knowler WC, Edelstein SE, Florez JC, Labrie F., Kahn SE, Goldberg RB, Barrett-Connor E., and Diabetes Prevention Program Research Group The Journal of clinical endocrinology and metabolism, 2015/07/22, p.jc20152328, (2015) Read More / View Supplemental Materials
Abstract
Therapeutic challenges in diabetes prevention: "We have not found the exercise pill".Srinivasan, S., and Florez JC Clinical pharmacology and therapeutics, 2015/05/13, (2015) Read More / View Supplemental Materials
Association of a 62 Variant Type 2 Diabetes Genetic Risk Score with Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.Dauriz, M., Porneala BC, Guo X., Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E., Bowden DW, Florez JC, Fornage M., Hivert MF, Jacobs DR Jr, Kabagambe EK, Lewis CE, Murabito JM, Rasmussen-Torvik LJ, Rich SS, Vassy JL, et al. Circulation. Cardiovascular genetics, 2015/03/24, (2015) Read More / View Supplemental Materials
Abstract
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Wessel, J., Chu AY, Willems SM, Wang S., Yaghootkar H., Brody JA, Dauriz M., Hivert MF, Raghavan S., Lipovich L., Hidalgo B., Fox K., Huffman JE, An P., Lu Y., Rasmussen-Torvik LJ, Grarup N., Ehm MG, Li L., Baldridge AS, et al. Nature communications, 2015/01/29, Volume 6, p.5897, (2015) Read More / View Supplemental Materials
Abstract
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.Mahajan, A., Sim X., Ng HJ, Manning A., Rivas MA, Highland HM, Locke AE, Grarup N., Im HK, Cingolani P., Flannick J., Fontanillas P., Fuchsberger C., Gaulton KJ, Teslovich TM, Rayner NW, Robertson NR, Beer NL, Rundle JK, Bork-Jensen J., et al. PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004876, (2015) Read More / View Supplemental Materials
Abstract
The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes.Walford, GA, Colomo N., Todd JN, Billings LK, Fernandez M., Chamarthi B., Warner AS, Davis J., Littleton KR, Hernandez AM, Fanelli RR, Lanier A., Barbato C., Ackerman RJ, Khan SQ, Bui R., Garber L., Stolerman ES, Moore AF, Huang C., et al. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0121553, (2015) Read More / View Supplemental Materials
Abstract
2014
Pathways targeted by anti-diabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.Segrè, AV, Wei N., DIAGRAM Consortium, investigators MAGIC, Altshuler D., and Florez JC Diabetes, 2014/11/03, (2014) Read More / View Supplemental Materials
Abstract
Effect of phosphodiesterase inhibition on insulin resistance in obese individuals.Ho, JE, Arora P., Walford GA, Ghorbani A., Guanaga DP, Dhakal BP, Nathan DI, Buys ES, Florez JC, Newton-Cheh C., Lewis GD, and Wang TJ Journal of the American Heart Association, 2014/09/11, Volume 3, Issue 5, (2014) Read More / View Supplemental Materials
Abstract
Metformin pharmacogenomics: current status and future directions.Pawlyk, AC, Giacomini KM, McKeon C., Shuldiner AR, and Florez JC Diabetes, 2014/08/01, Volume 63, Issue 8, p.2590-9, (2014) Read More / View Supplemental Materials
Abstract
Effects of Weight Loss, Weight Cycling, and Weight Loss Maintenance on Diabetes Incidence and Change in Cardiometabolic Traits in the Diabetes Prevention Program.Delahanty, LM, Pan Q., Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L., Franks PW, and for the Diabetes Prevention Program Research Group Diabetes care, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.Vimaleswaran, KS, Cavadino A., Berry DJ, investigators LifeLines Cohort Study, Jorde R., Dieffenbach AK, Lu C., Alves AC, Heerspink HJ, Tikkanen E., Eriksson J., Wong A., Mangino M., Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D., Zgaga L., et al. The lancet. Diabetes & endocrinology, 2014/06/25, (2014) Read More / View Supplemental Materials
Abstract
Metabolite Traits and Genetic Risk Provide Complementary Information for the Prediction of Future Type 2 Diabetes.Walford, GA, Porneala BC, Dauriz M., Vassy JL, Cheng S., Rhee EP, Wang TJ, Meigs JB, Gerszten RE, and Florez JC Diabetes care, 2014/06/19, (2014) Read More / View Supplemental Materials
Abstract
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.Consortium, SIGMA Type Diabetes 2, Estrada K., Aukrust I., Bjørkhaug L., Burtt NP, Mercader JM, García-Ortiz H., Huerta-Chagoya A., Moreno-Macías H., Walford G., Flannick J., Williams AL, Gómez-Vázquez MJ, Fernandez-Lopez JC, Martínez-Hernández A., Centeno-Cruz F., Mendoza-Caamal E., Revilla-Monsalve C., Islas-Andrade S., Córdova EJ, et al. JAMA : the journal of the American Medical Association, 2014/06/11, Volume 311, Issue 22, p.2305-14, (2014) Read More / View Supplemental Materials
Abstract
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.SIGMA Type 2 Diabetes, Consortium, Williams AL, Jacobs SB, Moreno-Macías H., Huerta-Chagoya A., Churchhouse C., Márquez-Luna C., García-Ortíz H., Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C., Florez JC, Orozco L., Haiman CA, Tusié-Luna T., and Altshuler D. Nature, 2014/02/06, Volume 506, Issue 7486, p.97-101, (2014) Read More / View Supplemental Materials
Abstract
Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes.Florez, JC JAMA : the journal of the American Medical Association, 2014/01/15, Volume 311, Issue 3, p.249-51, (2014) Read More / View Supplemental Materials
2013
Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus.Walford, GA, Davis J., Warner AS, Ackerman RJ, Billings LK, Chamarthi B., Fanelli RR, Hernandez AM, Huang C., Khan SQ, Littleton KR, Lo J., McCarthy RM, Rhee EP, Deik A., Stolerman E., Taylor A., Hudson MS, Wang TJ, Altshuler D., et al. Metabolism: clinical and experimental, 2013/12/01, Volume 62, Issue 12, p.1772-8, (2013) Read More / View Supplemental Materials
Abstract
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.Flannick, J., Beer NL, Bick AG, Agarwala V., Molnes J., Gupta N., Burtt NP, Florez JC, Meigs JB, Taylor H., Lyssenko V., Irgens H., Fox E., Burslem F., Johansson S., Brosnan MJ, Trimmer JK, Newton-Cheh C., Tuomi T., Molven A., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1380-5, (2013) Read More / View Supplemental Materials
Abstract
2-Aminoadipic acid is a biomarker for diabetes risk.Wang, TJ, Ngo D., Psychogios N., Dejam A., Larson MG, Vasan RS, Ghorbani A., O'Sullivan J., Cheng S., Rhee EP, Sinha S., McCabe E., Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M., Pierce KA, Souza AL, Yu Y., et al. The Journal of clinical investigation, 2013/10/01, Volume 123, Issue 10, p.4309-17, (2013) Read More / View Supplemental Materials
Abstract
Metabolite profiles during oral glucose challenge.Ho, JE, Larson MG, Vasan RS, Ghorbani A., Cheng S., Rhee EP, Florez JC, Clish CB, Gerszten RE, and Wang TJ Diabetes, 2013/08/01, Volume 62, Issue 8, p.2689-98, (2013) Read More / View Supplemental Materials
Abstract
A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort.Rhee, EP, Ho JE, Chen MH, Shen D., Cheng S., Larson MG, Ghorbani A., Shi X., Helenius IT, O'Donnell CJ, Souza AL, Deik A., Pierce KA, Bullock K., Walford GA, Vasan RS, Florez JC, Clish C., Yeh JR, Wang TJ, et al. Cell metabolism, 2013/07/02, Volume 18, Issue 1, p.130-43, (2013) Read More / View Supplemental Materials
Abstract
A combined epidemiologic and metabolomic approach improves CKD prediction.Rhee, EP, Clish CB, Ghorbani A., Larson MG, Elmariah S., McCabe E., Yang Q., Cheng S., Pierce K., Deik A., Souza AL, Farrell L., Domos C., Yeh RW, Palacios I., Rosenfield K., Vasan RS, Florez JC, Wang TJ, Fox CS, et al. Journal of the American Society of Nephrology : JASN, 2013/07/01, Volume 24, Issue 8, p.1330-8, (2013) Read More / View Supplemental Materials
Abstract
Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study.de Miguel-Yanes, JM, Porneala B., Pencina MJ, Fox CS, Florez JC, Siscovick DS, Dupuis J., and Meigs JB Journal of hypertension, 2013/02/19, (2013) Read More / View Supplemental Materials
Abstract
2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Manning, AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N., Chen H., Rybin D., Liu CT, Bielak LF, Prokopenko I., Amin N., Barnes D., Cadby G., Hottenga JJ, Ingelsson E., Jackson AU, Johnson T., Kanoni S., Ladenvall C., Lagou V., et al. Nature genetics, 2012/05/13, Volume 44, Issue 6, p.659-669, (2012) Read More / View Supplemental Materials
Abstract
Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.Mather, KJ, Christophi CA, Jablonski KA, Knowler WC, Goldberg RB, Kahn SE, Spector T., Dastani Z., Waterworth D., Richards JB, Funahashi T., Pi-Sunyer FX, Pollin TI, Florez JC, Franks PW, and for the Diabetes Prevention Program Research Group Diabetic medicine : a journal of the British Diabetic Association, 2012/03/24, (2012) Read More / View Supplemental Materials
Abstract
Effects of genetic variants previously associated with fasting glucose and insulin in the diabetes prevention program.Florez, JC, Jablonski KA, McAteer JB, Franks PW, Mason CC, Mather K., Horton E., Goldberg R., Dabelea D., Kahn SE, Arakaki RF, Shuldiner AR, Knowler WC, and Diabetes Prevention Program Research Group PloS one, 2012/01/01, Volume 7, Issue 9, p.e44424, (2012) Read More / View Supplemental Materials
Abstract
2011
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.Rhee, EP, Cheng S., Larson MG, Walford GA, Lewis GD, McCabe E., Yang E., Farrell L., Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, and Gerszten RE The Journal of clinical investigation, 2011/04/01, Volume 121, Issue 4, p.1402-11, (2011) Read More / View Supplemental Materials
Abstract
Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials
Abstract
2010
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Voight, BF, Scott LJ, Steinthorsdottir V., Morris AP, Dina C., Welch RP, Zeggini E., Huth C., Aulchenko YS, Thorleifsson G., McCulloch LJ, Ferreira T., Grallert H., Amin N., Wu G., Willer CJ, Raychaudhuri S., McCarroll SA, Langenberg C., Hofmann OM, et al. Nature genetics, 2010/07/01, Volume 42, Issue 7, p.579-89, (2010) Read More / View Supplemental Materials
Abstract
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Saxena, R., Hivert MF, Langenberg C., Tanaka T., Pankow JS, Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson AU, Kao WH, Li M., Glazer NL, Manning AK, Luan J., Stringham HM, Prokopenko I., Johnson T., Grarup N., Boesgaard TW, et al. Nature genetics, 2010/02/01, Volume 42, Issue 2, p.142-8, (2010) Read More / View Supplemental Materials
Abstract
2007
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.and of Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes BioMedical Rese, Saxena R., Voight BF, Lyssenko V., Burtt NP, de Bakker PI, Chen H., Roix JJ, Kathiresan S., Hirschhorn JN, Daly M. J., Hughes TE, Groop L., Altshuler D., Almgren P., Florez JC, Meyer J., Ardlie K., Bengtsson Boström K., Isomaa B., et al. Science (New York, N.Y.), 2007/06/01, Volume 316, Issue 5829, p.1331-6, (2007) Read More / View Supplemental Materials
Abstract
2006
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.Saxena, R., Gianniny L., Burtt NP, Lyssenko V., Giuducci C., Sjögren M., Florez JC, Almgren P., Isomaa B., Orho-Melander M., Lindblad U., Daly M. J., Tuomi T., Hirschhorn JN, Ardlie KG, Groop LC, and Altshuler D. Diabetes, 2006/10/01, Volume 55, Issue 10, p.2890-5, (2006) Read More / View Supplemental Materials
Abstract
  • Showing 1-31 of 31 Results