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2015
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.Hayes, MG, Urbanek M., Ehrmann DA, Armstrong LL, Lee JY, Sisk R., Karaderi T., Barber TM, McCarthy MI, Franks S., Lindgren CM, Welt CK, Diamanti-Kandarakis E., Panidis D., Goodarzi MO, Azziz R., Zhang Y., James RG, Olivier M., Kissebah AH, et al. Nature communications, 2015/08/18, Volume 6, p.7502, (2015) Read More / View Supplemental Materials
Abstract
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.Horikoshi, M., Mӓgi R., van de Bunt M., Surakka I., Sarin AP, Mahajan A., Marullo L., Thorleifsson G., Hӓgg S., Hottenga JJ, Ladenvall C., Ried JS, Winkler TW, Willems SM, Pervjakova N., Esko T., Beekman M., Nelson CP, Willenborg C., Wiltshire S., et al. PLoS genetics, 2015/07/01, Volume 11, Issue 7, p.e1005230, (2015) Read More / View Supplemental Materials
Abstract
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.Usher, CL, Handsaker RE, Esko T., Tuke MA, Weedon MN, Hastie AR, Cao H., Moon JE, Kashin S., Fuchsberger C., Metspalu A., Pato CN, Pato MT, McCarthy MI, Boehnke M., Altshuler DM, Frayling TM, Hirschhorn JN, and McCarroll SA Nature genetics, 2015/06/22, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Draisma, HH, Pool R., Kobl M., Jansen R., Petersen AK, Vaarhorst AA, Yet I., Haller T., Demirkan A., Esko T., Zhu G., Böhringer S., Beekman M., van Klinken JB, Römisch-Margl W., Prehn C., Adamski J., de Craen AJ, van Leeuwen EM, Amin N., et al. Nature communications, 2015/06/12, Volume 6, p.7208, (2015) Read More / View Supplemental Materials
Abstract
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study.Hägg, S., Fall T., Ploner A., Mägi R., Fischer K., Draisma HH, Kals M., de Vries PS, Dehghan A., Willems SM, Sarin AP, Kristiansson K., Nuotio ML, Havulinna AS, de Bruijn RF, Ikram MA, Kuningas M., Stricker BH, Franco OH, Benyamin B., et al. International journal of epidemiology, 2015/05/27, (2015) Read More / View Supplemental Materials
Abstract
The impact of low-frequency and rare variants on lipid levels.Surakka, I., Horikoshi M., Mägi R., Sarin AP, Mahajan A., Lagou V., Marullo L., Ferreira T., Miraglio B., Timonen S., Kettunen J., Pirinen M., Karjalainen J., Thorleifsson G., Hägg S., Hottenga JJ, Isaacs A., Ladenvall C., Beekman M., Esko T., et al. Nature genetics, 2015/05/11, (2015) Read More / View Supplemental Materials
Abstract
Human genomics. Effect of predicted protein-truncating genetic variants on the human transcriptome.Rivas, MA, Pirinen M., Conrad DF, Lek M., Tsang EK, Karczewski KJ, Maller JB, Kukurba KR, Deluca DS, Fromer M., Ferreira PG, Smith KS, Zhang R., Zhao F., Banks E., Poplin R., Ruderfer DM, Purcell SM, Tukiainen T., Minikel EV, et al. Science (New York, N.Y.), 2015/05/08, Volume 348, Issue 6235, p.666-9, (2015) Read More / View Supplemental Materials
Abstract
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.Moutsianas, L., Agarwala V., Fuchsberger C., Flannick J., Rivas MA, Gaulton KJ, Albers PK, GoT2D Consortium, McVean G., Boehnke M., Altshuler D., and McCarthy MI PLoS genetics, 2015/04/01, Volume 11, Issue 4, p.e1005165, (2015) Read More / View Supplemental Materials
Abstract
Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals.Nead, KT, Li A., Wehner MR, Neupane B., Gustafsson S., Butterworth A., Engert JC, Davis AD, Hegele RA, Miller R., den Hoed M., Khaw KT, Kilpeläinen TO, Wareham N., Edwards TL, Hallmans G., Varga TV, Kardia SL, Smith JA, Zhao W., et al. Human molecular genetics, 2015/03/17, (2015) Read More / View Supplemental Materials
Abstract
Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.Fall, T., Hägg S., Ploner A., Mägi R., Fischer K., Draisma HH, Sarin AP, Benyamin B., Ladenvall C., Åkerlund M., Kals M., Esko T., Nelson CP, Kaakinen M., Huikari V., Mangino M., Meirhaeghe A., Kristiansson K., Nuotio ML, Kobl M., et al. Diabetes, 2015/02/23, (2015) Read More / View Supplemental Materials
Abstract
Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
Abstract
New genetic loci link adipose and insulin biology to body fat distribution.Shungin, D., Winkler TW, Croteau-Chonka DC, Ferreira T., Locke AE, Mägi R., Strawbridge RJ, Pers TH, Fischer K., Justice AE, Workalemahu T., Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C., Gustafsson S., Day FR, Esko T., et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.187-96, (2015) Read More / View Supplemental Materials
Abstract
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.Mahajan, A., Sim X., Ng HJ, Manning A., Rivas MA, Highland HM, Locke AE, Grarup N., Im HK, Cingolani P., Flannick J., Fontanillas P., Fuchsberger C., Gaulton KJ, Teslovich TM, Rayner NW, Robertson NR, Beer NL, Rundle JK, Bork-Jensen J., et al. PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004876, (2015) Read More / View Supplemental Materials
Abstract
2014
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.Jaiswal, S., Fontanillas P., Flannick J., Manning A., Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N., Chavez A., Higgins JM, Moltchanov V., Kuo FC, Kluk MJ, Henderson B., Kinnunen L., Koistinen HA, Ladenvall C., Getz G., Correa A., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
Abstract
Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
Abstract
A novel common variant in DCST2 is associated with length in early life and height in adulthood.van der Valk, RJ, Kreiner-Møller E., Kooijman MN, Guxens M., Stergiakouli E., Sääf A., Bradfield JP, Geller F., Hayes MG, Cousminer DL, Körner A., Thiering E., Curtin JA, Myhre R., Huikari V., Joro R., Kerkhof M., Warrington NM, Pitkänen N., Ntalla I., et al. Human molecular genetics, 2014/10/03, (2014) Read More / View Supplemental Materials
Abstract
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.Perry, JR, Day F., Elks CE, Sulem P., Thompson DJ, Ferreira T., He C., Chasman DI, Esko T., Thorleifsson G., Albrecht E., Ang WQ, Corre T., Cousminer DL, Feenstra B., Franceschini N., Ganna A., Johnson AD, Kjellqvist S., Lunetta KL, et al. Nature, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.Lim, ET, Würtz P., Havulinna AS, Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem RM, Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004494, (2014) Read More / View Supplemental Materials
Abstract
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.Vimaleswaran, KS, Cavadino A., Berry DJ, investigators LifeLines Cohort Study, Jorde R., Dieffenbach AK, Lu C., Alves AC, Heerspink HJ, Tikkanen E., Eriksson J., Wong A., Mangino M., Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D., Zgaga L., et al. The lancet. Diabetes & endocrinology, 2014/06/25, (2014) Read More / View Supplemental Materials
Abstract
A Central Role for GRB10 in Regulation of Islet Function in Man.Prokopenko, I., Poon W., Mägi R., Prasad B R., Salehi SA, Almgren P., Osmark P., Bouatia-Naji N., Wierup N., Fall T., Stančáková A., Barker A., Lagou V., Osmond C., Xie W., Lahti J., Jackson AU, Cheng YC, Liu J., O'Connell JR, et al. PLoS genetics, 2014/04/01, Volume 10, Issue 4, p.e1004235, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Flannick, J., Thorleifsson G., Beer NL, Jacobs SB, Grarup N., Burtt NP, Mahajan A., Fuchsberger C., Atzmon G., Benediktsson R., Blangero J., Bowden DW, Brandslund I., Brosnan J., Burslem F., Chambers J., Cho YS, Christensen C., Douglas DA, Duggirala R., et al. Nature genetics, 2014/04/01, Volume 46, Issue 4, p.357-63, (2014) Read More / View Supplemental Materials
Abstract
A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.Damotte, V., Guillot-Noel L., Patsopoulos NA, Madireddy L., El Behi M., International Multiple Sclerosis Genetics Consortium, Ban M., Baranzini S., Barcellos L., Beecham G., Beecham A., Bernardinelli L., Booth D., Bos S., Buck D., Bush W., Comabella M., Compston A., Cotsapas C., Cournu-Rebeix I., et al. Genes and immunity, 2014/01/16, (2014) Read More / View Supplemental Materials
Abstract
Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci.Service, SK, Teslovich TM, Fuchsberger C., Ramensky V., Yajnik P., Koboldt DC, Larson DE, Zhang Q., Lin L., Welch R., Ding L., McLellan MD, O'Laughlin M., Fronick C., Fulton LL, Magrini V., Swift A., Elliott P., Jarvelin MR, Kaakinen M., et al. PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004147, (2014) Read More / View Supplemental Materials
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2013
Common variants associated with plasma triglycerides and risk for coronary artery disease.Do, R., Willer CJ, Schmidt EM, Sengupta S., Gao C., Peloso GM, Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich ML, Mora S., Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A., Den Hertog HM, Donnelly LA, Ehret GB, Esko T., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1345-52, (2013) Read More / View Supplemental Materials
Abstract
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.Ripke, S., O'Dushlaine C., Chambert K., Moran JL, Kähler AK, Akterin S., Bergen SE, Collins AL, Crowley JJ, Fromer M., Kim Y., Lee SH, Magnusson PK, Sanchez N., Stahl EA, Williams S., Wray NR, Xia K., Bettella F., Borglum AD, et al. Nature genetics, 2013/10/01, Volume 45, Issue 10, p.1150-9, (2013) Read More / View Supplemental Materials
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2012
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.Voight, BF, Kang HM, Ding J., Palmer CD, Sidore C., Chines PS, Burtt NP, Fuchsberger C., Li Y., Erdmann J., Frayling TM, Heid IM, Jackson AU, Johnson T., Kilpeläinen TO, Lindgren CM, Morris AP, Prokopenko I., Randall JC, Saxena R., et al. PLoS genetics, 2012/08/01, Volume 8, Issue 8, p.e1002793, (2012) Read More / View Supplemental Materials
Abstract
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Manning, AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N., Chen H., Rybin D., Liu CT, Bielak LF, Prokopenko I., Amin N., Barnes D., Cadby G., Hottenga JJ, Ingelsson E., Jackson AU, Johnson T., Kanoni S., Ladenvall C., Lagou V., et al. Nature genetics, 2012/05/13, Volume 44, Issue 6, p.659-669, (2012) Read More / View Supplemental Materials
Abstract
2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Speliotes, EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G., Jackson AU, Allen HL, Lindgren CM, Luan J., Mägi R., Randall JC, Vedantam S., Winkler TW, Qi L., Workalemahu T., Heid IM, Steinthorsdottir V., Stringham HM, Weedon MN, Wheeler E., et al. Nature genetics, 2010/11/01, Volume 42, Issue 11, p.937-48, (2010) Read More / View Supplemental Materials
Abstract
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Voight, BF, Scott LJ, Steinthorsdottir V., Morris AP, Dina C., Welch RP, Zeggini E., Huth C., Aulchenko YS, Thorleifsson G., McCulloch LJ, Ferreira T., Grallert H., Amin N., Wu G., Willer CJ, Raychaudhuri S., McCarroll SA, Langenberg C., Hofmann OM, et al. Nature genetics, 2010/07/01, Volume 42, Issue 7, p.579-89, (2010) Read More / View Supplemental Materials
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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Saxena, R., Hivert MF, Langenberg C., Tanaka T., Pankow JS, Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson AU, Kao WH, Li M., Glazer NL, Manning AK, Luan J., Stringham HM, Prokopenko I., Johnson T., Grarup N., Boesgaard TW, et al. Nature genetics, 2010/02/01, Volume 42, Issue 2, p.142-8, (2010) Read More / View Supplemental Materials
Abstract
2007
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.Winckler, W., Weedon MN, Graham RR, McCarroll SA, Purcell S., Almgren P., Tuomi T., Gaudet D., Boström KB, Walker M., Hitman G., Hattersley AT, McCarthy MI, Ardlie KG, Hirschhorn JN, Daly M. J., Frayling TM, Groop L., and Altshuler D. Diabetes, 2007/03/01, Volume 56, Issue 3, p.685-93, (2007) Read More / View Supplemental Materials
Abstract
  • Showing 1-31 of 31 Results