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2015
miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction.Guda, S., Brendel C., Renella R., Du P., Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J., De Boer H., Root DE, Milsom MD, Orkin SH, Gregory RI, and Williams DA Molecular therapy : the journal of the American Society of Gene Therapy, 2015/06/17, (2015) Read More / View Supplemental Materials
Abstract
Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions.Xu, J., Shao Z., Li D., Xie H., Kim W., Huang J., Taylor JE, Pinello L., Glass K., Jaffe JD, Yuan GC, and Orkin SH Molecular cell, 2015/01/07, (2015) Read More / View Supplemental Materials
Abstract
2014
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.Perry, JA, Kiezun A., Tonzi P., Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E., Pedamallu CS, Helman E., Taylor-Weiner A., McKenna A., Deluca DS, Lawrence MS, Ambrogio L., Sougnez C., Sivachenko A., Walensky LD, Wagle N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
A comparative encyclopedia of DNA elements in the mouse genome.Yue, F., Cheng Y., Breschi A., Vierstra J., Wu W., Ryba T., Sandstrom R., Ma Z., Davis C., Pope BD, Shen Y., Pervouchine DD, Djebali S., Thurman RE, Kaul R., Rynes E., Kirilusha A., Marinov GK, Williams BA, Trout D., et al. Nature, 2014/11/20, Volume 515, Issue 7527, p.355-64, (2014) Read More / View Supplemental Materials
Abstract
2013
Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis.Sankaran, VG, and Orkin SH Current opinion in genetics & development, 2013/03/07, (2013) Read More / View Supplemental Materials
Abstract
2012
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.Sankaran, VG, Ludwig LS, Sicinska E., Xu J., Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y., Orkin SH, Sicinski P., Lander E. S., and Lodish HF Genes & development, 2012/09/15, Volume 26, Issue 18, p.2075-87, (2012) Read More / View Supplemental Materials
Abstract
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia.Sankaran, VG, Ghazvinian R., Do R., Thiru P., Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander E. S., and Gazda HT The Journal of clinical investigation, 2012/07/02, Volume 122, Issue 7, p.2439-43, (2012) Read More / View Supplemental Materials
Abstract
2011
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.Sankaran, VG, Menne TF, Šćepanović D., Vergilio JA, Ji P., Kim J., Thiru P., Orkin SH, Lander E. S., and Lodish HF Proceedings of the National Academy of Sciences of the United States of America, 2011/01/25, Volume 108, Issue 4, p.1519-24, (2011) Read More / View Supplemental Materials
Abstract
2008
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.Lettre, G., Sankaran VG, Bezerra MA, Araújo AS, Uda M., Sanna S., Cao A., Schlessinger D., Costa FF, Hirschhorn JN, and Orkin SH Proceedings of the National Academy of Sciences of the United States of America, 2008/08/19, Volume 105, Issue 33, p.11869-74, (2008) Read More / View Supplemental Materials
Abstract
2006
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.Bourquin, JP, Subramanian A., Langebrake C., Reinhardt D., Bernard O., Ballerini P., Baruchel A., Cavé H., Dastugue N., Hasle H., Kaspers GL, Lessard M., Michaux L., Vyas P., van Wering E., Zwaan CM, Golub T. R., and Orkin SH Proceedings of the National Academy of Sciences of the United States of America, 2006/02/28, Volume 103, Issue 9, p.3339-44, (2006) Read More / View Supplemental Materials
Abstract
  • Showing 1-10 of 10 Results