New Publications

Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers.
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
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Expression of the p53 Target CDIP Correlates with Sensitivity to TNFα-Induced Apoptosis in Cancer Cells.
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Absolute quantification of somatic DNA alterations in human cancer.
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RNA-SeQC: RNA-seq metrics for quality control and process optimization.
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Scientific Publications

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2012

Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency.Wei, G., Margolin AA, Haery L., Brown E., Cucolo L., Julian B., Shehata S., Kung AL, Beroukhim R., and Golub T. R. Cancer cell, 2012/04/17, Volume 21, Issue 4, p.547-62, (2012) Read More / View Supplemental Materials

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Barretina, J., Caponigro G., Stransky N., Venkatesan K., Margolin AA, Kim S., Wilson CJ, Lehár J., Kryukov GV, Sonkin D., Reddy A., Liu M., Murray L., Berger MF, Monahan JE, Morais P., Meltzer J., Korejwa A., Jané-Valbuena J., Mapa FA, et al. Nature, 2012/03/28, Volume 483, Issue 7391, p.603-7, (2012) Read More / View Supplemental Materials

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.Luo, T., Masson K., Jaffe JD, Silkworth W., Ross NT, Scherer CA, Scholl C., Fröhling S., Carr SA, Stern AM, Schreiber SL, and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2012/02/21, Volume 109, Issue 8, p.2860-5, (2012) Read More / View Supplemental Materials

2011

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.Wang, L., Lawrence MS, Wan Y., Stojanov P., Sougnez C., Stevenson K., Werner L., Sivachenko A., Deluca DS, Zhang L., Zhang W., Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, Cibulskis K., Tesar B., Sievers QL, Shefler E., Gabriel S., et al. The New England journal of medicine, 2011/12/29, Volume 365, Issue 26, p.2497-506, (2011) Read More / View Supplemental Materials

A method for high-throughput gene expression signature analysis.Peck, D., Crawford ED, Ross KN, Stegmaier K., Golub T. R., and Lamb J. Genome biology, 2011/12/08, Volume 7, Issue 7, p.R61, (2011) Read More / View Supplemental Materials

Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers.Cheung, HW, Du J., Boehm JS, He F., Weir BA, Wang X., Butaney M., Sequist LV, Luo B., Engelman JA, Root DE, Meyerson M., Golub T. R., Jänne PA, and Hahn WC Cancer discovery, 2011/12/01, Volume 1, Issue 7, p.608-25, (2011) Read More / View Supplemental Materials

Stem cell gene expression programs influence clinical outcome in human leukemia.Eppert, K., Takenaka K., Lechman ER, Waldron L., Nilsson B., van Galen P., Metzeler KH, Poeppl A., Ling V., Beyene J., Canty AJ, Danska JS, Bohlander SK, Buske C., Minden MD, Golub T. R., Jurisica I., Ebert BL, and Dick JE Nature medicine, 2011/08/28, Volume 17, Issue 9, p.1086-93, (2011) Read More / View Supplemental Materials

The mutational landscape of head and neck squamous cell carcinoma.Stransky, N., Egloff AM, Tward AD, Kostic AD, Cibulskis K., Sivachenko A., Kryukov GV, Lawrence MS, Sougnez C., McKenna A., Shefler E., Ramos AH, Stojanov P., Carter SL, Voet D., Cortés ML, Auclair D., Berger MF, Saksena G., Guiducci C., et al. Science (New York, N.Y.), 2011/08/26, Volume 333, Issue 6046, p.1157-60, (2011) Read More / View Supplemental Materials

Humanized mice with ectopic artificial liver tissues.Chen, AA, Thomas DK, Ong LL, Schwartz RE, Golub T. R., and Bhatia SN Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11842-7, (2011) Read More / View Supplemental Materials

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials

mRNA expression signature of Gleason grade predicts lethal prostate cancer.Penney, KL, Sinnott JA, Fall K., Pawitan Y., Hoshida Y., Kraft P., Stark JR, Fiorentino M., Perner S., Finn S., Calza S., Flavin R., Freedman ML, Setlur S., Sesso HD, Andersson SO, Martin N., Kantoff PW, Johansson JE, Adami HO, et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/06/10, Volume 29, Issue 17, p.2391-6, (2011) Read More / View Supplemental Materials

Initial genome sequencing and analysis of multiple myeloma.Chapman, MA, Lawrence MS, Keats JJ, Cibulskis K., Sougnez C., Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M., Anderson KC, Ardlie KG, Auclair D., Baker A., Bergsagel PL, Bernstein BE, Drier Y., Fonseca R., Gabriel SB, Hofmeister CC, et al. Nature, 2011/03/24, Volume 471, Issue 7339, p.467-72, (2011) Read More / View Supplemental Materials

Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.Green, MR, Monti S., Dalla-Favera R., Pasqualucci L., Walsh NC, Schmidt-Supprian M., Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K., Golub T. R., Alt F. W., Shipp M. A., and Manis J. P. Proceedings of the National Academy of Sciences of the United States of America, 2011/02/15, Volume 108, Issue 7, p.2873-8, (2011) Read More / View Supplemental Materials

The genomic complexity of primary human prostate cancer.Berger, MF, Lawrence MS, Demichelis F., Drier Y., Cibulskis K., Sivachenko AY, Sboner A., Esgueva R., Pflueger D., Sougnez C., Onofrio R., Carter SL, Park K., Habegger L., Ambrogio L., Fennell T., Parkin M., Saksena G., Voet D., Ramos AH, et al. Nature, 2011/02/10, Volume 470, Issue 7333, p.214-20, (2011) Read More / View Supplemental Materials

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.Ding, Z., Wu CJ, Chu GC, Xiao Y., Ho D., Zhang J., Perry SR, Labrot ES, Wu X., Lis R., Hoshida Y., Hiller D., Hu B., Jiang S., Zheng H., Stegh AH, Scott KL, Signoretti S., Bardeesy N., Wang YA, et al. Nature, 2011/02/10, Volume 470, Issue 7333, p.269-73, (2011) Read More / View Supplemental Materials

Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Novershtern, N., Subramanian A., Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N., Yosef N., Chang CY, Shay T., Frampton GM, Drake AC, Leskov I., Nilsson B., Preffer F., Dombkowski D., Evans JW, Liefeld T., Smutko JS, Chen J., et al. Cell, 2011/01/21, Volume 144, Issue 2, p.296-309, (2011) Read More / View Supplemental Materials

2010

MicroRNA miR-125a controls hematopoietic stem cell number.Guo, S., Lu J., Schlanger R., Zhang H., Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B., Merkenschlager M., Golub T. R., and Scadden DT Proceedings of the National Academy of Sciences of the United States of America, 2010/08/10, Volume 107, Issue 32, p.14229-34, (2010) Read More / View Supplemental Materials

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials

The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.Zimmer, M., Lamb J., Ebert BL, Lynch M., Neil C., Schmidt E., Golub T. R., and Iliopoulos O. Cancer research, 2010/04/15, Volume 70, Issue 8, p.3071-9, (2010) Read More / View Supplemental Materials

Molecular sampling of prostate cancer: a dilemma for predicting disease progression.Sboner, A., Demichelis F., Calza S., Pawitan Y., Setlur SR, Hoshida Y., Perner S., Adami HO, Fall K., Mucci LA, Kantoff PW, Stampfer M., Andersson SO, Varenhorst E., Johansson JE, Gerstein MB, Golub T. R., Rubin MA, and Andrén O. BMC medical genomics, 2010/03/16, Volume 3, p.8, (2010) Read More / View Supplemental Materials

The landscape of somatic copy-number alteration across human cancers.Beroukhim, R., Mermel CH, Porter D., Wei G., Raychaudhuri S., Donovan J., Barretina J., Boehm JS, Dobson J., Urashima M., Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L., Greulich H., Reich M., Winckler W., Lawrence MS, Weir BA, et al. Nature, 2010/02/18, Volume 463, Issue 7283, p.899-905, (2010) Read More / View Supplemental Materials

2009

Dicer1 functions as a haploinsufficient tumor suppressor.Kumar, MS, Pester RE, Chen CY, Lane K., Chin C., Lu J., Kirsch DG, Golub T. R., and Jacks T. Genes & development, 2009/12/01, Volume 23, Issue 23, p.2700-4, (2009) Read More / View Supplemental Materials

Empirical Bayes analysis of quantitative proteomics experiments.Margolin, AA, Ong SE, Schenone M., Gould R., Schreiber SL, Carr SA, and Golub T. R. PloS one, 2009/10/14, Volume 4, Issue 10, p.e7454, (2009) Read More / View Supplemental Materials

Proteomic and genetic approaches identify Syk as an AML target.Hahn, CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K., Schinzel AC, Ross L., Galinsky I., Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M., Hahn WC, Carr SA, Golub T. R., Kung AL, and Stegmaier K. Cancer cell, 2009/10/06, Volume 16, Issue 4, p.281-94, (2009) Read More / View Supplemental Materials

Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.Hoshida, Y., Nijman SM, Kobayashi M., Chan JA, Brunet JP, Chiang DY, Villanueva A., Newell P., Ikeda K., Hashimoto M., Watanabe G., Gabriel S., Friedman SL, Kumada H., Llovet JM, and Golub T. R. Cancer research, 2009/09/15, Volume 69, Issue 18, p.7385-92, (2009) Read More / View Supplemental Materials

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.Olson, P., Lu J., Zhang H., Shai A., Chun MG, Wang Y., Libutti SK, Nakakura EK, Golub T. R., and Hanahan D. Genes & development, 2009/09/15, Volume 23, Issue 18, p.2152-65, (2009) Read More / View Supplemental Materials

microRNA expression during trophectoderm specification.Viswanathan, SR, Mermel CH, Lu J., Lu CW, Golub T. R., and Daley GQ PloS one, 2009/07/03, Volume 4, Issue 7, p.e6143, (2009) Read More / View Supplemental Materials

Lin28 promotes transformation and is associated with advanced human malignancies.Viswanathan, SR, Powers JT, Einhorn W., Hoshida Y., Ng TL, Toffanin S., O'Sullivan M., Lu J., Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R., Azam M., Teixeira J., Meyerson M., Hughes TP, Llovet JM, Radich J., et al. Nature genetics, 2009/07/01, Volume 41, Issue 7, p.843-8, (2009) Read More / View Supplemental Materials

Identification of AML1-ETO modulators by chemical genomics.Corsello, SM, Roti G., Ross KN, Chow KT, Galinsky I., DeAngelo DJ, Stone RM, Kung AL, Golub T. R., and Stegmaier K. Blood, 2009/06/11, Volume 113, Issue 24, p.6193-205, (2009) Read More / View Supplemental Materials

MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes.Ikeda, S., He A., Kong SW, Lu J., Bejar R., Bodyak N., Lee KH, Ma Q., Kang PM, Golub T. R., and Pu WT Molecular and cellular biology, 2009/04/01, Volume 29, Issue 8, p.2193-204, (2009) Read More / View Supplemental Materials

Identifying the proteins to which small-molecule probes and drugs bind in cells.Ong, SE, Schenone M., Margolin AA, Li X., Do K., Doud MK, Mani D. R., Kuai L., Wang X., Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub T. R., Gould RJ, Schreiber SL, and Carr SA Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4617-22, (2009) Read More / View Supplemental Materials

Prolonged therapy for hepatitis C with low-dose peginterferon.Hoshida, Y., and Golub T. R. The New England journal of medicine, 2009/03/12, Volume 360, Issue 11, p.1152; author reply 1152-3, (2009) Read More / View Supplemental Materials

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.Du, J., Bernasconi P., Clauser KR, Mani D. R., Finn SP, Beroukhim R., Burns M., Julian B., Peng XP, Hieronymus H., Maglathlin RL, Lewis TA, Liau LM, Nghiemphu P., Mellinghoff IK, Louis DN, Loda M., Carr SA, Kung AL, and Golub T. R. Nature biotechnology, 2009/01/01, Volume 27, Issue 1, p.77-83, (2009) Read More / View Supplemental Materials

2008

Highly parallel identification of essential genes in cancer cells.Luo, B., Cheung HW, Subramanian A., Sharifnia T., Okamoto M., Yang X., Hinkle G., Boehm JS, Beroukhim R., Weir BA, Mermel C., Barbie DA, Awad T., Zhou X., Nguyen T., Piqani B., Li C., Golub T. R., Meyerson M., Hacohen N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/12/23, Volume 105, Issue 51, p.20380-5, (2008) Read More / View Supplemental Materials

Gene expression in fixed tissues and outcome in hepatocellular carcinoma.Hoshida, Y., Villanueva A., Kobayashi M., Peix J., Chiang DY, Camargo A., Gupta S., Moore J., Wrobel MJ, Lerner J., Reich M., Chan JA, Glickman JN, Ikeda K., Hashimoto M., Watanabe G., Daidone MG, Roayaie S., Schwartz M., Thung S., et al. The New England journal of medicine, 2008/11/06, Volume 359, Issue 19, p.1995-2004, (2008) Read More / View Supplemental Materials

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.Li, Z., Lu J., Sun M., Mi S., Zhang H., Luo RT, Chen P., Wang Y., Yan M., Qian Z., Neilly MB, Jin J., Zhang Y., Bohlander SK, Zhang DE, Larson RA, Le Beau MM, Thirman MJ, Golub T. R., Rowley JD, et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/10/07, Volume 105, Issue 40, p.15535-40, (2008) Read More / View Supplemental Materials

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.Tam, WF, Gu TL, Chen J., Lee BH, Bullinger L., Fröhling S., Wang A., Monti S., Golub T. R., and Gilliland DG Blood, 2008/09/01, Volume 112, Issue 5, p.1981-92, (2008) Read More / View Supplemental Materials

Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.Haining, WN, Ebert BL, Subrmanian A., Wherry EJ, Eichbaum Q., Evans JW, Mak R., Rivoli S., Pretz J., Angelosanto J., Smutko JS, Walker BD, Kaech SM, Ahmed R., Nadler LM, and Golub T. R. Journal of immunology (Baltimore, Md. : 1950), 2008/08/01, Volume 181, Issue 3, p.1859-68, (2008) Read More / View Supplemental Materials

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation.Hahn, CK, Ross KN, Warrington IM, Mazitschek R., Kanegai CM, Wright RD, Kung AL, Golub T. R., and Stegmaier K. Proceedings of the National Academy of Sciences of the United States of America, 2008/07/15, Volume 105, Issue 28, p.9751-6, (2008) Read More / View Supplemental Materials

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.Setlur, SR, Mertz KD, Hoshida Y., Demichelis F., Lupien M., Perner S., Sboner A., Pawitan Y., Andrén O., Johnson LA, Tang J., Adami HO, Calza S., Chinnaiyan AM, Rhodes D., Tomlins S., Fall K., Mucci LA, Kantoff PW, Stampfer MJ, et al. Journal of the National Cancer Institute, 2008/06/04, Volume 100, Issue 11, p.815-25, (2008) Read More / View Supplemental Materials

MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.Lu, J., Guo S., Ebert BL, Zhang H., Peng X., Bosco J., Pretz J., Schlanger R., Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, and Golub T. R. Developmental cell, 2008/06/01, Volume 14, Issue 6, p.843-53, (2008) Read More / View Supplemental Materials

Large-scale chemical dissection of mitochondrial function.Wagner, BK, Kitami T., Gilbert TJ, Peck D., Ramanathan A., Schreiber SL, Golub T. R., and Mootha VK Nature biotechnology, 2008/03/01, Volume 26, Issue 3, p.343-51, (2008) Read More / View Supplemental Materials

An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.Ebert, BL, Galili N., Tamayo P., Bosco J., Mak R., Pretz J., Tanguturi S., Ladd-Acosta C., Stone R., Golub T. R., and Raza A. PLoS medicine, 2008/02/01, Volume 5, Issue 2, p.e35, (2008) Read More / View Supplemental Materials

Modeling genomic diversity and tumor dependency in malignant melanoma.Lin, WM, Baker AC, Beroukhim R., Winckler W., Feng W., Marmion JM, Laine E., Greulich H., Tseng H., Gates C., Hodi FS, Dranoff G., Sellers WR, Thomas RK, Meyerson M., Golub T. R., Dummer R., Herlyn M., Getz G., and Garraway LA Cancer research, 2008/02/01, Volume 68, Issue 3, p.664-73, (2008) Read More / View Supplemental Materials

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.Ebert, BL, Pretz J., Bosco J., Chang CY, Tamayo P., Galili N., Raza A., Root DE, Attar E., Ellis SR, and Golub T. R. Nature, 2008/01/17, Volume 451, Issue 7176, p.335-9, (2008) Read More / View Supplemental Materials

Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomasTakeyama, K., Monti S., Manis J. P., Cin Dal P., Getz G., Beroukhim R., Dutt S., Aster J. C., Alt F. W., Golub T. R., and Shipp M. A. Oncogene, 2008/01/10/, Volume 27, Issue 3, p.318 - 22, (2008) Read More / View Supplemental Materials

2007

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.Mi, S., Lu J., Sun M., Li Z., Zhang H., Neilly MB, Wang Y., Qian Z., Jin J., Zhang Y., Bohlander SK, Le Beau MM, Larson RA, Golub T. R., Rowley JD, and Chen J. Proceedings of the National Academy of Sciences of the United States of America, 2007/12/11, Volume 104, Issue 50, p.19971-6, (2007) Read More / View Supplemental Materials

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.Fröhling, S., Scholl C., Levine RL, Loriaux M., Boggon TJ, Bernard OA, Berger R., Döhner H., Döhner K., Ebert BL, Teckie S., Golub T. R., Jiang J., Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, et al. Cancer cell, 2007/12/01, Volume 12, Issue 6, p.501-13, (2007) Read More / View Supplemental Materials

Subclass mapping: identifying common subtypes in independent disease data sets.Hoshida, Y., Brunet JP, Tamayo P., Golub T. R., and Mesirov J. P. PloS one, 2007/11/21, Volume 2, Issue 11, p.e1195, (2007) Read More / View Supplemental Materials

Altered microRNA expression in human heart disease.Ikeda, S., Kong SW, Lu J., Bisping E., Zhang H., Allen PD, Golub T. R., Pieske B., and Pu WT Physiological genomics, 2007/11/14, Volume 31, Issue 3, p.367-73, (2007) Read More / View Supplemental Materials

Identification of prostate cancer modifier pathways using parental strain expression mapping.Xu, Q., Majumder PK, Ross K., Shim Y., Golub T. R., Loda M., and Sellers WR Proceedings of the National Academy of Sciences of the United States of America, 2007/11/06, Volume 104, Issue 45, p.17771-6, (2007) Read More / View Supplemental Materials

Comment on "The consensus coding sequences of human breast and colorectal cancers".Getz, G., Höfling H., Mesirov J. P., Golub T. R., Meyerson M., Tibshirani R., and Lander E. S. Science (New York, N.Y.), 2007/09/14, Volume 317, Issue 5844, p.1500, (2007) Read More / View Supplemental Materials

Impaired microRNA processing enhances cellular transformation and tumorigenesis.Kumar, MS, Lu J., Mercer KL, Golub T. R., and Jacks T. Nature genetics, 2007/05/01, Volume 39, Issue 5, p.673-7, (2007) Read More / View Supplemental Materials

Prospective isolation and global gene expression analysis of definitive and visceral endoderm.Sherwood, RI, Jitianu C., Cleaver O., Shaywitz DA, Lamenzo JO, Chen AE, Golub T. R., and Melton DA Developmental biology, 2007/04/15, Volume 304, Issue 2, p.541-55, (2007) Read More / View Supplemental Materials

Genomics: global views of leukaemia.Golub, T. R. Nature, 2007/04/12, Volume 446, Issue 7137, p.739-40, (2007) Read More / View Supplemental Materials

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.Stegmaier, K., Wong JS, Ross KN, Chow KT, Peck D., Wright RD, Lessnick SL, Kung AL, and Golub T. R. PLoS medicine, 2007/04/01, Volume 4, Issue 4, p.e122, (2007) Read More / View Supplemental Materials

Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution.Byers, RJ, Di Vizio D., O'connell F., Tholouli E., Levenson RM, Gossage K., Twomey D., Yang Y., Benedettini E., Rose J., Ligon KL, Finn SP, Golub T. R., and Loda M. The Journal of molecular diagnostics : JMD, 2007/02/01, Volume 9, Issue 1, p.20-9, (2007) Read More / View Supplemental Materials

IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas.Pegtel, DM, Subramanian A., Meritt D., Tsai CH, Sheen TS, Golub T. R., and Thorley-Lawson DA Cancer research, 2007/01/15, Volume 67, Issue 2, p.474-81, (2007) Read More / View Supplemental Materials

2006

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.Hieronymus, H., Lamb J., Ross KN, Peng XP, Clement C., Rodina A., Nieto M., Du J., Stegmaier K., Raj SM, Maloney KN, Clardy J., Hahn WC, Chiosis G., and Golub T. R. Cancer cell, 2006/10/01, Volume 10, Issue 4, p.321-30, (2006) Read More / View Supplemental Materials

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.Wei, G., Twomey D., Lamb J., Schlis K., Agarwal J., Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R., Golub T. R., and Armstrong SA Cancer cell, 2006/10/01, Volume 10, Issue 4, p.331-42, (2006) Read More / View Supplemental Materials

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.Lamb, J., Crawford ED, Peck D., Modell JW, Blat IC, Wrobel MJ, Lerner J., Brunet JP, Subramanian A., Ross KN, Reich M., Hieronymus H., Wei G., Armstrong SA, Haggarty SJ, Clemons PA, Wei R., Carr SA, Lander E. S., and Golub T. R. Science (New York, N.Y.), 2006/09/29, Volume 313, Issue 5795, p.1929-35, (2006) Read More / View Supplemental Materials

Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies.Tholouli, E., Hoyland JA, Di Vizio D., O'connell F., Macdermott SA, Twomey D., Levenson R., Yin JA, Golub T. R., Loda M., and Byers R. Biochemical and biophysical research communications, 2006/09/22, Volume 348, Issue 2, p.628-36, (2006) Read More / View Supplemental Materials

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.Krivtsov, AV, Twomey D., Feng Z., Stubbs MC, Wang Y., Faber J., Levine JE, Wang J., Hahn WC, Gilliland DG, Golub T. R., and Armstrong SA Nature, 2006/08/17, Volume 442, Issue 7104, p.818-22, (2006) Read More / View Supplemental Materials

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.Pikman, Y., Lee BH, Mercher T., McDowell E., Ebert BL, Gozo M., Cuker A., Wernig G., Moore S., Galinsky I., DeAngelo DJ, Clark JJ, Lee SJ, Golub T. R., Wadleigh M., Gilliland DG, and Levine RL PLoS medicine, 2006/07/01, Volume 3, Issue 7, p.e270, (2006) Read More / View Supplemental Materials

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.Smith, R., Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub T. R., and Lessnick SL Cancer cell, 2006/05/01, Volume 9, Issue 5, p.405-16, (2006) Read More / View Supplemental Materials

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.Stanbrough, M., Bubley GJ, Ross K., Golub T. R., Rubin MA, Penning TM, Febbo PG, and Balk SP Cancer research, 2006/03/01, Volume 66, Issue 5, p.2815-25, (2006) Read More / View Supplemental Materials

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.Bourquin, JP, Subramanian A., Langebrake C., Reinhardt D., Bernard O., Ballerini P., Baruchel A., Cavé H., Dastugue N., Hasle H., Kaspers GL, Lessard M., Michaux L., Vyas P., van Wering E., Zwaan CM, Golub T. R., and Orkin SH Proceedings of the National Academy of Sciences of the United States of America, 2006/02/28, Volume 103, Issue 9, p.3339-44, (2006) Read More / View Supplemental Materials

BRAF mutation predicts sensitivity to MEK inhibition.Solit, DB, Garraway LA, Pratilas CA, Sawai A., Getz G., Basso A., Ye Q., Lobo JM, She Y., Osman I., Golub T. R., Sebolt-Leopold J., Sellers WR, and Rosen N. Nature, 2006/01/19, Volume 439, Issue 7074, p.358-62, (2006) Read More / View Supplemental Materials

2005

Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis.Pegtel, DM, Subramanian A., Sheen TS, Tsai CH, Golub T. R., and Thorley-Lawson DA Journal of virology, 2005/12/01, Volume 79, Issue 24, p.15430-42, (2005) Read More / View Supplemental Materials

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Subramanian, A., Tamayo P., Mootha VK, Mukherjee S., Ebert BL, Gillette MA, Paulovich A., Pomeroy SL, Golub T. R., Lander E. S., and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25, Volume 102, Issue 43, p.15545-50, (2005) Read More / View Supplemental Materials

Gefitinib induces myeloid differentiation of acute myeloid leukemia.Stegmaier, K., Corsello SM, Ross KN, Wong JS, DeAngelo DJ, and Golub T. R. Blood, 2005/10/15, Volume 106, Issue 8, p.2841-8, (2005) Read More / View Supplemental Materials

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.Shepard, JL, Amatruda JF, Stern HM, Subramanian A., Finkelstein D., Ziai J., Finley KR, Pfaff KL, Hersey C., Zhou Y., Barut B., Freedman M., Lee C., Spitsbergen J., Neuberg D., Weber G., Golub T. R., Glickman JN, Kutok JL, Aster J. C., et al. Proceedings of the National Academy of Sciences of the United States of America, 2005/09/13, Volume 102, Issue 37, p.13194-9, (2005) Read More / View Supplemental Materials

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.Garraway, LA, Widlund HR, Rubin MA, Getz G., Berger AJ, Ramaswamy S., Beroukhim R., Milner DA, Granter SR, Du J., Lee C., Wagner SN, Li C., Golub T. R., Rimm DL, Meyerson ML, Fisher DE, and Sellers WR Nature, 2005/07/07, Volume 436, Issue 7047, p.117-22, (2005) Read More / View Supplemental Materials

An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray.Ebert, BL, Lee MM, Pretz JL, Subramanian A., Mak R., Golub T. R., and Sieff CA Blood, 2005/06/15, Volume 105, Issue 12, p.4620-6, (2005) Read More / View Supplemental Materials

MicroRNA expression profiles classify human cancers.Lu, J., Getz G., Miska EA, Alvarez-Saavedra E., Lamb J., Peck D., Sweet-Cordero A., Ebert BL, Mak RH, Ferrando AA, Downing J. R., Jacks T., Horvitz HR, and Golub T. R. Nature, 2005/06/09, Volume 435, Issue 7043, p.834-8, (2005) Read More / View Supplemental Materials

Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer.Febbo, PG, Lowenberg M., Thorner AR, Brown M., Loda M., and Golub T. R. The Journal of urology, 2005/05/01, Volume 173, Issue 5, p.1772-7, (2005) Read More / View Supplemental Materials

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.Levine, RL, Wadleigh M., Cools J., Ebert BL, Wernig G., Huntly BJ, Boggon TJ, Wlodarska I., Clark JJ, Moore S., Adelsperger J., Koo S., Lee JC, Gabriel S., Mercher T., D'Andrea A., Fröhling S., Döhner K., Marynen P., Vandenberghe P., et al. Cancer cell, 2005/04/01, Volume 7, Issue 4, p.387-97, (2005) Read More / View Supplemental Materials

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.Xie, X., Lu J., Kulbokas E. J., Golub T. R., Mootha V., Lindblad-Toh K., Lander E. S., and Kellis M. Nature, 2005/03/17, Volume 434, Issue 7031, p.338-45, (2005) Read More / View Supplemental Materials

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.Monti, S., Savage KJ, Kutok JL, Feuerhake F., Kurtin P., Mihm M., Wu B., Pasqualucci L., Neuberg D., Aguiar RC, Dal Cin P., Ladd C., Pinkus GS, Salles G., Harris NL, Dalla-Favera R., Habermann TM, Aster J. C., Golub T. R., and Shipp M. A. Blood, 2005/03/01, Volume 105, Issue 5, p.1851-61, (2005) Read More / View Supplemental Materials

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.Wang, J., Iwasaki H., Krivtsov A., Febbo PG, Thorner AR, Ernst P., Anastasiadou E., Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub T. R., Armstrong SA, Akashi K., and Korsmeyer SJ The EMBO journal, 2005/01/26, Volume 24, Issue 2, p.368-81, (2005) Read More / View Supplemental Materials

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.Sweet-Cordero, A., Mukherjee S., Subramanian A., You H., Roix JJ, Ladd-Acosta C., Mesirov J., Golub T. R., and Jacks T. Nature genetics, 2005/01/01, Volume 37, Issue 1, p.48-55, (2005) Read More / View Supplemental Materials

2004

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.Berger, R., Febbo PG, Majumder PK, Zhao JJ, Mukherjee S., Signoretti S., Campbell KT, Sellers WR, Roberts TM, Loda M., Golub T. R., and Hahn WC Cancer research, 2004/12/15, Volume 64, Issue 24, p.8867-75, (2004) Read More / View Supplemental Materials

Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.Du, J., Widlund HR, Horstmann MA, Ramaswamy S., Ross K., Huber WE, Nishimura EK, Golub T. R., and Fisher DE Cancer cell, 2004/12/01, Volume 6, Issue 6, p.565-76, (2004) Read More / View Supplemental Materials

Genomic approaches to hematologic malignancies.Ebert, BL, and Golub T. R. Blood, 2004/08/15, Volume 104, Issue 4, p.923-32, (2004) Read More / View Supplemental Materials

Toward a functional taxonomy of cancer.Golub, T. R. Cancer cell, 2004/08/01, Volume 6, Issue 2, p.107-8, (2004) Read More / View Supplemental Materials

A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.Halmos, B., Bassères DS, Monti S., D'Aló F., Dayaram T., Ferenczi K., Wouters BJ, Huettner CS, Golub T. R., and Tenen D. G. Cancer research, 2004/06/15, Volume 64, Issue 12, p.4137-47, (2004) Read More / View Supplemental Materials

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.Majumder, PK, Febbo PG, Bikoff R., Berger R., Xue Q., McMahon LM, Manola J., Brugarolas J., McDonnell TJ, Golub T. R., Loda M., Lane HA, and Sellers WR Nature medicine, 2004/06/01, Volume 10, Issue 6, p.594-601, (2004) Read More / View Supplemental Materials

The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1.Coletta, RD, Christensen K., Reichenberger KJ, Lamb J., Micomonaco D., Huang L., Wolf DM, Müller-Tidow C., Golub T. R., Kawakami K., and Ford HL Proceedings of the National Academy of Sciences of the United States of America, 2004/04/27, Volume 101, Issue 17, p.6478-83, (2004) Read More / View Supplemental Materials

Metagenes and molecular pattern discovery using matrix factorization.Brunet, JP, Tamayo P., Golub T. R., and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2004/03/23, Volume 101, Issue 12, p.4164-9, (2004) Read More / View Supplemental Materials

Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation.Stegmaier, K., Ross KN, Colavito SA, O'Malley S., Stockwell BR, and Golub T. R. Nature genetics, 2004/03/01, Volume 36, Issue 3, p.257-63, (2004) Read More / View Supplemental Materials

2001

Multiclass cancer diagnosis using tumor gene expression signaturesRamaswamy, S., Tamayo P., Rifkin R., Mukherjee S., Yeang C. H., Angelo M., Ladd C., Reich M., Latulippe E., Mesirov J. P., Poggio T., Gerald W., Loda M., Lander E. S., and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2001/12/18/, Volume 98, Issue 26, p.15149 - 54, (2001) Read More / View Supplemental Materials

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclassesBhattacharjee, A., Richards W. G., Staunton J., Li C., Monti S., Vasa P., Ladd C., Beheshti J., Bueno R., Gillette M., Loda M., Weber G., Mark E. J., Lander E. S., Wong W., Johnson B. E., Golub T. R., Sugarbaker D. J., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2001/11/20/, Volume 98, Issue 24, p.13790 - 5, (2001) Read More / View Supplemental Materials

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclassesBhattacharjee, A., Richards W. G., Staunton J., Li C., Monti S., Vasa P., Ladd C., Beheshti J., Bueno R., Gillette M., Loda M., Weber G., Mark E. J., Lander E. S., Wong W., Johnson B. E., Golub T. R., Sugarbaker D. J., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2001/11/20/, Volume 98, Issue 24, p.13790 - 5, (2001) Read More / View Supplemental Materials

Chemosensitivity prediction by transcriptional profilingStaunton, J. E., Slonim D. K., Coller H. A., Tamayo P., Angelo M. J., Park J., Scherf U., Lee J. K., Reinhold W. O., Weinstein J. N., Mesirov J. P., Lander E. S., and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2001/09/11/, Volume 98, Issue 19, p.10787 - 92, (2001) Read More / View Supplemental Materials

c-Myc is a critical target for c/EBPalpha in granulopoiesisJohansen, L. M., Iwama A., Lodie T. A., Sasaki K., Felsher D. W., Golub T. R., and Tenen D. G. Molecular and Cellular Biology, 2001/06//, Volume 21, Issue 11, p.3789 - 806, (2001) Read More / View Supplemental Materials

Genome-wide views of cancerGolub, T. R. The New England Journal of Medicine, 2001/02/22/, Volume 344, Issue 8, p.601 - 2, (2001) Read More / View Supplemental Materials

Genome-wide views of cancerGolub, T. R. The New England Journal of Medicine, 2001/02/22/, Volume 344, Issue 8, p.601 - 2, (2001) Read More / View Supplemental Materials