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2014
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.Lane, AA, Chapuy B., Lin CY, Tivey T., Li H., Townsend EC, van Bodegom D., Day TA, Wu SC, Liu H., Yoda A., Alexe G., Schinzel AC, Sullivan TJ, Malinge S., Taylor JE, Stegmaier K., Jaffe JD, Bustin M., Te Kronnie G., et al. Nature genetics, 2014/04/20, (2014) Read More / View Supplemental Materials
Abstract
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Knoechel, B., Roderick JE, Williamson KE, Zhu J., Lohr JG, Cotton MJ, Gillespie SM, Fernandez D., Ku M., Wang H., Piccioni F., Silver SJ, Jain M., Pearson D., Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A., et al. Nature genetics, 2014/03/02, (2014) Read More / View Supplemental Materials
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2013
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.Chapuy, B., McKeown MR, Lin CY, Monti S., Roemer MG, Qi J., Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E., Kung AL, Rodig SJ, Young RA, Shipp M. A., and Bradner JE Cancer cell, 2013/12/09, Volume 24, Issue 6, p.777-90, (2013) Read More / View Supplemental Materials
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The use of small molecules in somatic-cell reprogramming.Federation, AJ, Bradner JE, and Meissner A. Trends in cell biology, 2013/10/30, (2013) Read More / View Supplemental Materials
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Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation.Frumm, SM, Fan ZP, Ross KN, Duvall JR, Gupta S., VerPlank L., Suh BC, Holson E., Wagner FF, Smith WB, Paranal RM, Bassil CF, Qi J., Roti G., Kung AL, Bradner JE, Tolliday N., and Stegmaier K. Chemistry & biology, 2013/05/23, Volume 20, Issue 5, p.713-25, (2013) Read More / View Supplemental Materials
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Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition.Puissant, A., Frumm SM, Alexe G., Bassil CF, Qi J., Chanthery YH, Nekritz EA, Zeid R., Gustafson WC, Greninger P., Garnett MJ, McDermott U., Benes CH, Kung AL, Weiss WA, Bradner JE, and Stegmaier K. Cancer discovery, 2013/03/01, Volume 3, Issue 3, p.308-323, (2013) Read More / View Supplemental Materials
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2012
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Q., Goldenson B., Silver SJ, Schenone M., Dancik V., Huang Z., Wang LZ, Lewis TA, An WF, Li X., Bray MA, Thiollier C., Diebold L., Gilles L., Vokes MS, Moore CB, Bliss-Moreau M., VerPlank L., Tolliday NJ, Mishra R., et al. Cell, 2012/08/03, Volume 150, Issue 3, p.575-89, (2012) Read More / View Supplemental Materials
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2011
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials
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Discovery of histone deacetylase 8 selective inhibitors.Tang, W., Luo T., Greenberg EF, Bradner JE, and Schreiber SL Bioorganic & medicinal chemistry letters, 2011/05/01, Volume 21, Issue 9, p.2601-5, (2011) Read More / View Supplemental Materials
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2010
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials
Abstract
Chemical phylogenetics of histone deacetylases.Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.238-243, (2010) Read More / View Supplemental Materials
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2009
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.Patel, V., Mazitschek R., Coleman B., Nguyen C., Urgaonkar S., Cortese J., Barker RH, Greenberg E., Tang W., Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, and Clardy J. Journal of medicinal chemistry, 2009/04/23, Volume 52, Issue 8, p.2185-7, (2009) Read More / View Supplemental Materials
Abstract
Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.Bowers, AA, West N., Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O., Bradner JE, and Williams RM Organic letters, 2009/03/19, Volume 11, Issue 6, p.1301-4, (2009) Read More / View Supplemental Materials
Abstract
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.Bowers, AA, Greshock TJ, West N., Estiu G., Schreiber SL, Wiest O., Williams RM, and Bradner JE Journal of the American Chemical Society, 2009/03/04, Volume 131, Issue 8, p.2900-5, (2009) Read More / View Supplemental Materials
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2008
Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.Bowers, A., West N., Taunton J., Schreiber SL, Bradner JE, and Williams RM Journal of the American Chemical Society, 2008/08/20, Volume 130, Issue 33, p.11219-22, (2008) Read More / View Supplemental Materials
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2007
Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.Vegas, AJ, Bradner JE, Tang W., McPherson OM, Greenberg EF, Koehler AN, and Schreiber SL Angewandte Chemie (International ed. in English), 2007/09/17, Volume 46, Issue 42, p.7960-4, (2007) Read More / View Supplemental Materials
2006
A method for the covalent capture and screening of diverse small molecules in a microarray format.Bradner, JE, McPherson OM, and Koehler AN Nature protocols, 2006/12/21, Volume 1, Issue 5, p.2344-52, (2006) Read More / View Supplemental Materials
Abstract
SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.Duan, Z., Bradner JE, Greenberg E., LeVine R., Foster R., Mahoney J., and Seiden MV Clinical cancer research : an official journal of the American Association for Cancer Research, 2006/11/15, Volume 12, Issue 22, p.6844-52, (2006) Read More / View Supplemental Materials
Abstract
A robust small-molecule microarray platform for screening cell lysates.Bradner, JE, McPherson OM, Mazitschek R., Barnes-Seeman D., Shen JP, Dhaliwal J., Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P., Schreiber SL, and Koehler AN Chemistry & biology, 2006/05/01, Volume 13, Issue 5, p.493-504, (2006) Read More / View Supplemental Materials
Abstract
2005
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.Hideshima, T., Bradner JE, Wong J., Chauhan D., Richardson P., Schreiber SL, and Anderson KC Proceedings of the National Academy of Sciences of the United States of America, 2005/06/14, Volume 102, Issue 24, p.8567-72, (2005) Read More / View Supplemental Materials
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  • Showing 1-20 of 20 Results