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  • Showing 1-13 of 13 Results
2011
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials
Abstract
Discovery of histone deacetylase 8 selective inhibitors.Tang, W., Luo T., Greenberg EF, Bradner JE, and Schreiber SL Bioorganic & medicinal chemistry letters, 2011/05/01, Volume 21, Issue 9, p.2601-5, (2011) Read More / View Supplemental Materials
Abstract
2010
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials
Abstract
Chemical phylogenetics of histone deacetylases.Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.238-243, (2010) Read More / View Supplemental Materials
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2009
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.Patel, V., Mazitschek R., Coleman B., Nguyen C., Urgaonkar S., Cortese J., Barker RH, Greenberg E., Tang W., Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, and Clardy J. Journal of medicinal chemistry, 2009/04/23, Volume 52, Issue 8, p.2185-7, (2009) Read More / View Supplemental Materials
Abstract
Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.Bowers, AA, West N., Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O., Bradner JE, and Williams RM Organic letters, 2009/03/19, Volume 11, Issue 6, p.1301-4, (2009) Read More / View Supplemental Materials
Abstract
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.Bowers, AA, Greshock TJ, West N., Estiu G., Schreiber SL, Wiest O., Williams RM, and Bradner JE Journal of the American Chemical Society, 2009/03/04, Volume 131, Issue 8, p.2900-5, (2009) Read More / View Supplemental Materials
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2008
Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.Bowers, A., West N., Taunton J., Schreiber SL, Bradner JE, and Williams RM Journal of the American Chemical Society, 2008/08/20, Volume 130, Issue 33, p.11219-22, (2008) Read More / View Supplemental Materials
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2007
Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.Vegas, AJ, Bradner JE, Tang W., McPherson OM, Greenberg EF, Koehler AN, and Schreiber SL Angewandte Chemie (International ed. in English), 2007/09/17, Volume 46, Issue 42, p.7960-4, (2007) Read More / View Supplemental Materials
2006
A method for the covalent capture and screening of diverse small molecules in a microarray format.Bradner, JE, McPherson OM, and Koehler AN Nature protocols, 2006/12/21, Volume 1, Issue 5, p.2344-52, (2006) Read More / View Supplemental Materials
Abstract
SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.Duan, Z., Bradner JE, Greenberg E., LeVine R., Foster R., Mahoney J., and Seiden MV Clinical cancer research : an official journal of the American Association for Cancer Research, 2006/11/15, Volume 12, Issue 22, p.6844-52, (2006) Read More / View Supplemental Materials
Abstract
A robust small-molecule microarray platform for screening cell lysates.Bradner, JE, McPherson OM, Mazitschek R., Barnes-Seeman D., Shen JP, Dhaliwal J., Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P., Schreiber SL, and Koehler AN Chemistry & biology, 2006/05/01, Volume 13, Issue 5, p.493-504, (2006) Read More / View Supplemental Materials
Abstract
2005
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.Hideshima, T., Bradner JE, Wong J., Chauhan D., Richardson P., Schreiber SL, and Anderson KC Proceedings of the National Academy of Sciences of the United States of America, 2005/06/14, Volume 102, Issue 24, p.8567-72, (2005) Read More / View Supplemental Materials
Abstract
  • Showing 1-13 of 13 Results