Recent Broad Publications

Comparative analysis of RNA sequencing methods for degraded or low-input samples.
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Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.
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Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells.
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Entering the age of whole-exome sequencing in rheumatic diseases: Novel insights into disease pathogenicity.
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Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
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Scientific Publications

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Filters: Author is Weïwer, M [Clear All Filters]

2013

Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif.Wagner, FF, Olson DE, Gale JP, Kaya T., Weïwer M., Aidoud N., Thomas M., Davoine EL, Lemercier BC, Zhang YL, and Holson EB Journal of medicinal chemistry, 2013/02/18, (2013) Read More / View Supplemental Materials

2012

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Weïwer, M., Spoonamore J., Wei J., Guichard B., Ross NT, Masson K., Silkworth W., Dandapani S., Palmer M., Scherer CA, Stern AM, Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2012/12/13, Volume 3, Issue 12, p.1034-1038, (2012) Read More / View Supplemental Materials

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Dockendorff, C., Nagiec MM, Weïwer M., Buhrlage S., Ting A., Nag PP, Germain A., Kim HJ, Youngsaye W., Scherer C., Bennion M., Xue L., Stanton BZ, Lewis TA, Macpherson L., Palmer M., Foley MA, Perez JR, and Schreiber SL ACS medicinal chemistry letters, 2012/10/11, Volume 3, Issue 10, p.808-813, (2012) Read More / View Supplemental Materials

Development of small-molecule probes that selectively kill cells induced to express mutant RAS.Weïwer, M., Bittker JA, Lewis TA, Shimada K., Yang WS, Macpherson L., Dandapani S., Palmer M., Stockwell BR, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/02/15, Volume 22, Issue 4, p.1822-6, (2012) Read More / View Supplemental Materials

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.Heidebrecht RW, Jr, Mulrooney C., Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E., Dandapani S., Dick J., Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M., Guha R., Hinkson P., Kramer M., Lukens AK, Masi D., Marcaurelle LA, et al. ACS medicinal chemistry letters, 2012/02/09, Volume 3, Issue 2, p.112-117, (2012) Read More / View Supplemental Materials

2011

Unbiased binding assays for discovering small-molecule probes and drugs.Kemp, MM, Weïwer M., and Koehler AN Bioorganic & medicinal chemistry, 2011/12/24, (2011) Read More / View Supplemental Materials

A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials