Scientific Publications

A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials

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Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials

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Chemical phylogenetics of histone deacetylases.Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.238-243, (2010) Read More / View Supplemental Materials

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Abstract

Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.Bowers, AA, West N., Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O., Bradner JE, and Williams RM Organic letters, 2009/03/19, Volume 11, Issue 6, p.1301-4, (2009) Read More / View Supplemental Materials

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Abstract

Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.Bowers, AA, Greshock TJ, West N., Estiu G., Schreiber SL, Wiest O., Williams RM, and Bradner JE Journal of the American Chemical Society, 2009/03/04, Volume 131, Issue 8, p.2900-5, (2009) Read More / View Supplemental Materials

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Abstract

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.Bowers, A., West N., Taunton J., Schreiber SL, Bradner JE, and Williams RM Journal of the American Chemical Society, 2008/08/20, Volume 130, Issue 33, p.11219-22, (2008) Read More / View Supplemental Materials

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Abstract