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  • Showing 1-8 of 8 Results
2016
Trans-ethnic Meta-Analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.Liu, CT, Raghavan S., Maruthur N., Kabagambe EK, Hong J., Ng MC, Hivert MF, Lu Y., An P., Bentley AR, Drolet AM, Gaulton KJ, Guo X., Armstrong LL, Irvin MR, Li M., Lipovich L., Rybin DV, Taylor KD, Agyemang C., et al. American journal of human genetics, 2016/06/15, (2016) Read More / View Supplemental Materials
Abstract
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.Han, B., Pouget JG, Slowikowski K., Stahl E., Lee CH, Diogo D., Hu X., Park YR, Kim E., Gregersen PK, Dahlqvist SR, Worthington J., Martin J., Eyre S., Klareskog L., Huizinga T., Chen WM, Onengut-Gumuscu S., Rich SS, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, et al. Nature genetics, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.Pattaro, C., Teumer A., Gorski M., Chu AY, Li M., Mijatovic V., Garnaas M., Tin A., Sorice R., Li Y., Taliun D., Olden M., Foster M., Yang Q., Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C., Tayo B., et al. Nature communications, 2016/01/21, Volume 7, p.10023, (2016) Read More / View Supplemental Materials
Abstract
2015
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.Lenz, TL, Deutsch AJ, Han B., Hu X., Okada Y., Eyre S., Knapp M., Zhernakova A., Huizinga TW, Abecasis G., Becker J., Boeckxstaens GE, Chen WM, Franke A., Gladman DD, Gockel I., Gutierrez-Achury J., Martin J., Nair RP, Nöthen MM, et al. Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Hu, X., Deutsch AJ, Lenz TL, Onengut-Gumuscu S., Han B., Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, and Raychaudhuri S. Nature genetics, 2015/07/13, (2015) Read More / View Supplemental Materials
Abstract
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Onengut-Gumuscu, S., Chen WM, Burren O., Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E., Bonnie JK, Szpak M., Schofield E., Achuthan P., Guo H., Fortune MD, Stevens H., Walker NM, Ward LD, Kundaje A., Kellis M., Daly M. J., Barrett JC, et al. Nature genetics, 2015/03/09, (2015) Read More / View Supplemental Materials
Abstract
2014
Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells.Hu, X., Im HK, Raj T., Brennan PJ, Trynka G., Teslovich N., Slowikowski K., Chen WM, Onengut S., Baecher-Allan C., De Jager PL, Rich SS, Stranger BE, Brenner MB, and Raychaudhuri S. PLoS genetics, 2014/06/01, Volume 10, Issue 6, p.e1004404, (2014) Read More / View Supplemental Materials
Abstract
Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2.Huang, J., Huffman JE, Yamkauchi M., Trompet S., Asselbergs FW, Sabater-Lleal M., Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W., Dehghan A., Johnson AD, Truong V., Folkersen L., Yang Q., Oudot-Mellkah T., Buckley BM, et al. Arteriosclerosis, thrombosis, and vascular biology, 2014/02/27, (2014) Read More / View Supplemental Materials
Abstract
  • Showing 1-8 of 8 Results