Recent Broad Publications
- Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Read More / View Supplemental Materials - Genetic risk variants in African Americans with multiple sclerosis.
Read More / View Supplemental Materials - Hopping between Differentiation States in Lung Adenocarcinoma.
Read More / View Supplemental Materials - Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.
Read More / View Supplemental Materials - The Genome of Anopheles darlingi, the main neotropical malaria vector.
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Discovery of the first histone deacetylase 6/8 dual inhibitors. Journal of medicinal chemistry, 2013/06/13, Volume 56, Issue 11, p.4816-20, (2013)
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Abstract
Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif. Journal of medicinal chemistry, 2013/02/18, (2013)
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The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer biology & therapy, 2011/09/15, Volume 12, Issue 6, p.484-93, (2011)
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An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.16962-76, (2010)
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