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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2013
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Hartwell, KA, Miller PG, Mukherjee S., Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M., Järås M., Puram R., Dancik V., Al-Shahrour F., Kindler T., Tothova Z., Chattopadhyay S., Hasaka T., Narayan R., Dai M., Huang C., Shterental S., et al. Nature chemical biology, 2013/12/01, Volume 9, Issue 12, p.840-8, (2013) Read More / View Supplemental Materials
Abstract
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.Basu, A., Bodycombe NE, Cheah JH, Price EV, Liu K., Schaefer GI, Ebright RY, Stewart ML, Ito D., Wang S., Bracha AL, Liefeld T., Wawer M., Gilbert JC, Wilson AJ, Stransky N., Kryukov GV, Dancik V., Barretina J., Garraway LA, et al. Cell, 2013/08/29, Volume 154, Issue 5, p.1151-61, (2013) Read More / View Supplemental Materials
Abstract
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.Adams, DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, and Schreiber SL ACS chemical biology, 2013/03/25, (2013) Read More / View Supplemental Materials
Abstract
2012
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Weïwer, M., Spoonamore J., Wei J., Guichard B., Ross NT, Masson K., Silkworth W., Dandapani S., Palmer M., Scherer CA, Stern AM, Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2012/12/13, Volume 3, Issue 12, p.1034-1038, (2012) Read More / View Supplemental Materials
Abstract
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials
Abstract
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Q., Goldenson B., Silver SJ, Schenone M., Dancik V., Huang Z., Wang LZ, Lewis TA, An WF, Li X., Bray MA, Thiollier C., Diebold L., Gilles L., Vokes MS, Moore CB, Bliss-Moreau M., VerPlank L., Tolliday NJ, Mishra R., et al. Cell, 2012/08/03, Volume 150, Issue 3, p.575-89, (2012) Read More / View Supplemental Materials
Abstract
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.Luo, T., Masson K., Jaffe JD, Silkworth W., Ross NT, Scherer CA, Scholl C., Fröhling S., Carr SA, Stern AM, Schreiber SL, and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2012/02/21, Volume 109, Issue 8, p.2860-5, (2012) Read More / View Supplemental Materials
Abstract
2011
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials
Abstract
2010
Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials
  • Showing 1-10 of 10 Results